Neurobiology of Auditory Language Perception

听觉语言感知的神经生物学

• 批准号: 7850187
• 负责人: Gregory Hickok
• 金额: $ 29.14万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850187
• 关键词: Adopted; Anterior; Auditory; Brain region; Cereals; Comprehension; Dorsal; Functional Magnetic Resonance Imaging; Goals; Language; Left; Lesion; Linguistics; Maps; Methods; Music; Neurobiology; Perception; Process; Research; Semantics; Staging; Stream; Structure; Structure of middle temporal gyrus; Structure of superior temporal sulcus; Superior temporal gyrus; Support System; System; Temporal Lobe; Work; auditory comprehension; language perception; lexical; phonology; programs; relating to nervous system; research study; syntax

We employ functional MRI and lesion methods to map cortical systems supporting the perception and comprehension of auditory language. The studies are theoretically guided on the broadest scale by our dorsal-ventral framework for the neural organization of language, which holds that the majority of computational systems supporting language comprehension (the ventral stream) are located in the temporal lobe. We target three broad computational systems: (1) phonological-level systems, (2) sentence-level systemss, and (3) lexical-semantic-level systems which are juxtaposed between, and interact with (1) & (2). Thus, the present proposal aims to map the large-scale landscape of language perception/comprehension systems. Aim 1: To map cortical regions supporting phonological-level processes, their interaction with lexical-semantic systems, and their relation to non-linguistic processes. A major goal is to distinguish systems supporting sublexical (segmental) and lexical (word) stages of phonological processing/representation. Experiments proposed in this section are guided by the following hypotheses, (i) Sublexical processes are computed on dorsal aspects of the superior temporal gyrus (STG) whereas lexical- level phonological processes involve ventral aspects of the STG. (ii)Neural structures in the posterior middle temporal gyrus (pMTG), interface lexical-phonological systems with widely distributed lexical- semantic networks, (iii)Phonological systems, both sublexical and lexical, are bilaterally organized, while the proposed phonological-semantic interface system is more left dominant. Aim 2: To map cortical regions supporting sentence-level processes, their interaction with lexical-semantic systems, and their interaction with non-linguistic processes. Experiments proposed in this section are guided by the following hypotheses, (i) Sentence-level processes involve fields in the anterior temporal lobe (ATL), and interacts with lexical- semantic networks via a posterior temporal lobe interface network, (ii)Processing phrasal prosody involves anterior portions of the STG, whereas syntactic processes involve more ventral anterior STS/MTG regions, (iii) Systems supporting the processing of phrasal prosody share neural territory with non-linguistic auditory processes (e.g..music), whereas syntactic processes are carried out in circumscribed and domain-specific brain regions.

我们采用功能性MRI和病变方法来绘制支持感知和的皮质系统 听觉语言的理解。从理论上讲，这些研究是根据我们的最大规模引导的 语言神经组织的背腹侧框架，该框架认为大多数 支持语言理解的计算系统（腹侧流）位于时间上 叶。我们针对三个广泛的计算系统：（1）语音级系统，（2）句子级 系统，以及（3）词汇语义级别的系统，它们在（并与（1）＆（2）相互作用之间并列。 因此，本提案旨在绘制语言知觉/理解的大规模景观 系统。目的1：绘制支持语音级过程的皮质区域，它们与 词汇语义系统及其与非语言过程的关系。一个主要目标是区分 支持Sublexical（分段）和词汇（单词）阶段的系统 处理/表示。本节提出的实验以以下假设为指导，（i） 在上颞回（STG）的背面上计算出突变过程，而词汇 - 水平的语音过程涉及STG的腹侧方面。 （ii）后部神经结构 中颞回（PMTG），界面词语 - 语音系统，具有广泛分布的词汇 语义网络（iii）语音系统（既有词汇和词汇）是双侧组织的 拟议的语音声音界面系统更为主导。目标2：绘制皮质区域 支持句子级的过程，与词汇语义系统的互动及其互动 与非语言过程。本节提出的实验以以下假设为指导， （i）句子级的过程涉及前颞叶（ATL）中的字段，并与词汇相互作用 语义网络通过后颞叶界面网络，（ii）处理短语韵律涉及 STG的前部部分，而句法过程涉及更多腹侧前STS/MTG区域， （iii）支持短语韵律处理的系统与非语言听觉共享神经区域 过程（例如，音乐），而句法过程则以限定和域特异性进行 大脑区域。