Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

基本信息

批准号：
10379013
负责人：
Satdarshan Singh Monga
金额：
$ 4.63万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2022-03-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10379013
关键词：
Academic Medical Centers Administrative Supplement Area Award Basic Science Biology Biomedical Research Cells Clinical Collaborations Communities Complex Comprehension Core Facility Development Digestive System Disorders Disease Education Educational workshop Electronic Mail Ensure Environment Equipment Fostering Functional disorder Funding Goals Health Healthcare Hepatic Hepatic Tissue Hepatobiliary Hepatocarcinogenesis Hepatocyte Human Individual Infrastructure Institutes Institution Instruction Interdisciplinary Study Interest Group Investigation Leadership Liver Liver diseases Medical center Medicine Mentors Mentorship Mission Molecular Pathology Patients Physicians Process Records Regenerative Medicine Research Research Personnel Resources Schedule Science Scientist Services Technology Time Tissue Sample Tissue imaging Translations Transplantation Universities University of Pittsburgh Cancer Institute Wait Time Work base bench to bedside career cellular imaging chronic liver disease clinical care clinical practice commercialization cost cryostat environmental enrichment for laboratory animals health care delivery human disease imaging facilities improved improved outcome injury and repair innovation interdisciplinary collaboration interest member multidisciplinary next generation novel programs prospective recruit research and development response service delivery service programs success technology development

项目摘要

The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician- basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting-edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

匹兹堡肝脏研究中心 (PLRC) 于 2016 年成立，是大家高度热情的结果。领导力，这来自于双方以资源形式提供的强有力的机构支持和承诺匹兹堡大学医学中心 (UPMC) 和匹兹堡大学 (UP) 确实如此。代表了医疗服务领域的先驱 UPMC 与著名的 UP 之间的成功合作伙伴关系研究、发现、教育和创新的领导者，其核心使命是促进对肝胆损伤和修复的细胞和分子基础的了解，PLRC 带来了一群非常强大的研究人员聚集在一起，从事基础和转化肝脏研究，在过去的两年里，PLRC 汇集了众多会员，为肝病患者提供临床护理。由代表多个部门的 80 名调查员和审核员（49 名正式成员）组成 UP 和 UPMC 内的机构作为一个社区，通过定期的网络、医生促进了这一点。基础科学家圆桌会议、研讨会和讲习班，丰富环境，使其有利于 PLRC 已将其组织为 3 个高度的组织，以加强现有的合作并建立新的伙伴关系。功能性科学兴趣小组（SIG）-再生医学、慢性肝病和肝脏肿瘤发生——具有重叠的成员资格和定期安排的互动，促进科学的研究通过相当新颖的丰富计划，为对话提供了肥沃的环境，使得定期举行 SIG 圆桌会议成为可能。医生和科学家之间就精心挑选的主题进行对话并促进合作等为了在 PLRC 研究人员的实验室中开展有意义的研究，我们有建立了 3 个高度集成的生物医学研究核心和一个提供最先进技术的临床部分和创新服务，使尖端研究和转化从实验室到临床。同样，PLRC。确定新的研究人员，并通过试点和可行性计划支持他们的研究和通过纵向指导和提供职业和专业机会发展为独立调查员除了科学支持外，还通过机构支持提供特别奖励来资助发展活动。促进医生和基础科学家互动、技术开发和所有上述服务和功能都是为了辨别复杂的磨难。通过促进肝胆损伤和修复领域的研究来改善肝脏健康和疾病创新、协作的跨学科、跨学科和多学科研究，对人类产生可持续的影响在行政核心的支持下，强有力的领导和组织确保了健康。事实上，PLRC 领导层利用了该机构的许多现有优势，如 CTSI、创新研究所和库尔特计划以及与匹兹堡大学等现有机构结成联盟癌症研究所、Starzl 移植研究所和麦高恩再生医学研究所扩建 PLRC 为其所有成员提供服务和福利，并最终改善他们的科学、翻译因此，最终，通过他们的综合服务和计划，实现了长期的目标。 PLRC 的目标是促进肝胆病理生理学领域有影响力的科学并提高本地和全球的肝脏健康和护理。