Improving Genetic Counseling for BRCA+ Mothers

改善 BRCA 母亲的遗传咨询

基本信息

批准号：
10292670
负责人：
BETH N PESHKIN
金额：
$ 6.08万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-02 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10292670
关键词：
Academic Medical Centers Administrative Supplement Area Behavioral Behavioral Research Behavioral Sciences Breast Cancer Risk Factor Cancer Control Cancer Control Research Cancer Survivor Child Clinical Communication Competence Comprehensive Cancer Center Data Disadvantaged Distress Doctor of Philosophy Exposure to Family Fellowship Genetic Genetic Counseling Goals Growth Health Health behavior Hereditary Breast Carcinoma Inherited Intervention Journals K-Series Research Career Programs Lead Learning Longevity Malignant Neoplasms Manuscripts Mentors Mentorship Methodology Mothers Outcome Parents Peer Review Personal Satisfaction Persons Population Heterogeneity Positioning Attribute Postdoctoral Fellow Preparation Public Health Publications Recording of previous events Research Research Methodology Research Personnel Testing Training United States National Institutes of Health Universities behavioral outcome behavioral study cancer health disparity cancer prevention cancer risk carrier status experience genetic testing health related quality of life improved interest meetings professor programs psychologic psychosocial social sociodemographics theories virtual

项目摘要

Project Abstract The purpose of this NIH/NCI administrative supplement to R01CA246589 is to provide support, mentorship, and training to Glynnis McDonnell, PhD, as a postdoctoral fellow under the mentorship of Kenneth Tercyak and Beth Peshkin at Georgetown University's Lombardi Comprehensive Cancer Center, Cancer Prevention and Control Program. Over a two-year period, this fellowship will promote the applicant's/fellow's growth as an independent behavioral science researcher in the area of cancer control and prevention with a focus on family communication through six major activities: 1) mentored research experiences with the parent study team; 2) advanced training in mixed-methods research (qualitative-quantitative analysis of behavioral data) to advance outcomes of genetic counseling; 3) participation in didactic opportunities through Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, and the Cancer Prevention and Control Program; 4) attendance at national scientific meetings (virtual, or in-person when resumed); 5) preparation of manuscripts for publication in peer-reviewed journals, and; 6) developing and submitting an NIH/NCI research career development award application to extend the learning. This supplement opportunity will also allow the applicant to enhance her competencies in behavioral research theory and methodology through exposure to the parent study’s RCT research implementation, and help develop expertise in the content area of genetic counseling interventions for families at high breast cancer risk. With interests in psychosocial kinship factors influencing health behaviors across the lifespan, the applicant aims to: 1) characterize mothers’ perspectives about the social and psychological advantages and disadvantages of communicating with children about BRCA genetic testing, inherited cancer risks, and cancer prevention, and 2) examine associations among maternal BRCA carrier status and cancer history with mother-child distress, as well as sociodemographic moderators of distress. Given well-established disparities in cancer outcomes, and the potential for genetics to transform clinical and public health approaches to cancer risk identification and management, the proposed training plan is significant because it will inform Healthy People 2030 goals surrounding genetic counseling for hereditary breast cancer, increasing the health-related quality of life of cancer survivors, and doing so equitably across diverse populations. After training, the applicant will be positioned to lead high-impact research in this area.

项目摘要 NIH/NCI 对 R01CA246589 的行政补充的目的是提供支持、指导、并在 Kenneth Tercyak 的指导下接受 Glynnis McDonnell 博士的培训，成为博士后研究员乔治城大学隆巴迪综合癌症中心的贝丝·佩什金 (Beth Peshkin) 负责癌症预防和控制计划在两年内，该奖学金将促进申请人/研究员的成长。癌症控制和预防领域的独立行为科学研究人员，重点关注家庭通过六项主要活动进行沟通：1）与家长研究团队指导研究经验；2）混合方法研究（行为数据的定性定量分析）的高级培训，以推进遗传咨询的结果；3）通过乔治城大学参与教学机会医疗中心、隆巴迪综合癌症中心和癌症预防和控制计划 4) 参加国家科学会议（虚拟会议，或恢复时亲自参加）；5）准备手稿；在同行评审期刊上发表，以及；6) 开发并提交 NIH/NCI 研究生涯发展奖申请也将允许申请人延长学习时间。通过接触家长来提高她在行为研究理论和方法方面的能力研究的RCT研究实施，并帮助发展遗传咨询内容领域的专业知识对乳腺癌高风险家庭的干预措施，对影响心理社会亲属关系的因素感兴趣。整个生命周期的健康行为，申请人的目标是：1）描述母亲对与儿童沟通 BRCA 遗传的社会和心理优势和劣势检测、遗传性癌症风险和癌症预防，2) 检查母亲 BRCA 之间的关联携带者状况和癌症病史以及母子痛苦，以及社会人口学调节因素鉴于癌症结果的明显差异以及遗传学改变的潜力。癌症风险识别和管理的临床和公共卫生方法、拟议的培训计划意义重大，因为它将为“健康人 2030”围绕遗传性遗传咨询的目标提供信息乳腺癌，提高癌症幸存者的健康相关生活质量，并在各个领域公平地这样做经过培训后，申请人将能够领导该领域的高影响力研究。