Pittsburgh Liver Research Center

匹兹堡肝脏研究中心

基本信息

批准号：
10117236
负责人：
Satdarshan Singh Monga
金额：
$ 117.06万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-03-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10117236
关键词：
Academic Medical Centers Area Award Basic Science Biomedical Research Clinical Collaborations Communities Complex Comprehension Continuing Education Core Facility Development Disease Education Educational workshop Ensure Environment Experimental Models Fostering Functional disorder Funding Goals Health Healthcare Hepatic Hepatobiliary Hepatocarcinogenesis Human Individual Infrastructure Institutes Institution Instruction Interdisciplinary Study Interest Group Investigation Leadership Liver Liver diseases Medical center Medicine Mentors Mentorship Mission Molecular Molecular Target Outcome Pathology Patients Physicians Process Records Regenerative Medicine Research Research Personnel Resources Sampling Schedule Science Scientist Services Time Translating Translational Research Translations Transplantation Universities University of Pittsburgh Cancer Institute base bench to bedside biomarker discovery burden of illness career chronic liver disease clinical care clinical practice commercialization diagnostic biomarker environmental enrichment for laboratory animals health care delivery human data improved improved outcome injury and repair innovation interdisciplinary collaboration interest member multidisciplinary next generation novel programs prospective recruit research and development service programs special interest group technology development

项目摘要

Abstract The inception of the Pittsburgh Liver Research Center (PLRC) in 2016 was the result of high enthusiasm of the leadership, which came with strong institutional support and commitment in the form of resources from both the University of Pittsburgh Medical Center (UPMC) and the University of Pittsburgh (UP). PLRC truly represents a successful partnership between UPMC, a pioneer in healthcare delivery and the UP, a renowned leader in research, discovery, education, and innovation. With the centralized mission of promoting the understanding of the cellular and molecular basis of hepatobiliary injury and repair, the PLRC has brought together a very strong group of investigators and clinicians engaged in basic and translational liver research and in the delivery of clinical care to liver patients. Over the last 2 years, PLRC has brought together the membership composed of 80 investigators and clinicians (49 full members) representing multiple departments and institutions within the UP and UPMC, as one community. This was facilitated by regular networking, physician-basic scientist roundtables, seminars and workshops, to enrich the environment making it conducive to strengthening existing collaborations and initiating new partnerships. PLRC has organized itself into 3 highly functional scientific interest groups (SIGs)−Regenerative Medicine, Chronic Liver Diseases, and Liver Tumorigenesis−with overlapping membership and regularly scheduled interactions facilitating a scientifically fertile environment for dialogue through a rather novel Enrichment program. SIG roundtables allow recurring dialogue between physicians and scientists on carefully selected topics and foster collaborations and more meaningful research. To enable pioneering and impactful science in the labs of PLRC investigators, we have established 3 highly integrated biomedical research cores and a clinical component that provide state-of-the-art and innovative services to enable cutting- edge research and translation from bench to bedside. Likewise, PLRC identifies new investigators and, through Pilot and Feasibility programs, supports their research and development as independent investigators through longitudinal mentorship and offering career and professional development activities in addition to scientific support. Special awards via institutional support allow funding of team science projects that promote physician and basic scientist interactions, technology development and commercialization. All of the above services and functions that are aimed at discerning complex tribulations in hepatic health and disease via research in the area of hepatobiliary injury and repair through promoting innovative, collaborative inter-, trans and multi-disciplinary research, to make a sustainable impact on human health, are ensured by a strong leadership and organization provided under the aegis of an Administrative Core. In fact, the PLRC leadership has leveraged many existing strengths of the institute like CTSI, Innovation Institute and the Coulter program as well as formed alliances with existing institutes like the University of Pittsburgh Cancer Institute, Starzl Transplant Institute and the McGowan Institute of Regenerative Medicine to expand services and benefits provided by the PLRC to all its members and eventually better their science, translation and commercialization. Thus, eventually, through their integrated services and programs, the long-term objective of the PLRC is to promote impactful science in the area of hepatobiliary pathophysiology and improve the hepatic health and care, both locally and globally.

抽象的匹兹堡肝脏研究中心 (PLRC) 于 2016 年成立，是大家高度热情的结果。领导力，这来自于双方以资源形式提供的强有力的机构支持和承诺匹兹堡大学医学中心 (UPMC) 和匹兹堡大学 (UP) 真正代表了一个。医疗保健领域的先驱 UPMC 与研究领域的著名领导者 UP 之间的成功合作伙伴关系，发现、教育和创新，其核心使命是促进对细胞和细胞的理解。肝胆损伤和修复的分子基础，PLRC 聚集了一支非常强大的研究人员队伍和登山者从事基础和转化肝脏研究以及为肝脏患者提供临床护理。在过去的两年里，PLRC 汇集了由 80 名调查员和精神病学家组成的会员（其中 49 名是成员）代表 UP 和 UPMC 内的多个部门和机构，作为一个社区。通过定期网络、医师-基础科学家圆桌会议、研讨会和讲习班来促进，以丰富 PLRC 的环境有利于加强现有合作并建立新的伙伴关系。组织成 3 个功能强大的科学兴趣小组 (SIG)——再生医学、慢性肝病、和肝脏肿瘤发生——具有重叠的成员资格和定期安排的互动，促进科学的研究通过相当新颖的丰富计划，为对话创造了肥沃的环境，允许反复进行对话。医生和科学家之间就精心挑选的主题进行交流，并促进合作和更有意义的研究。为了在 PLRC 研究人员的实验室中实现开创性和有影响力的科学，我们建立了 3 个高度集成的实验室生物医学研究核心和临床部分提供最先进的创新服务，以实现切割- 同样，PLRC 还通过 Pilot 确定了新的研究人员并从实验室到临床进行了前沿研究和转化。可行性计划，通过纵向支持他们作为独立研究者的研究和开发除了科学支持之外，还提供指导并提供职业和专业发展活动。通过机构支持，为促进医生和基础科学家互动的团队科学项目提供资金，以上所有的服务和功能都是为了有洞察力。通过肝胆损伤和修复领域的研究，了解肝脏健康和疾病的复杂磨难促进创新、协作的跨学科、跨学科和多学科研究，对人类产生可持续的影响事实上，在行政核心的支持下提供强有力的领导和组织来确保健康。 PLRC 领导层利用了该研究所的许多现有优势，如 CTSI、创新研究所和库尔特计划并与匹兹堡大学癌症研究所、Starzl 等现有机构结成联盟移植研究所和麦高恩再生医学研究所扩大移植研究所提供的服务和福利 PLRC 向其所有成员提供帮助，并最终改善他们的科学、翻译和商业化。通过其综合服务和项目，PLRC 的长期目标是促进以下领域有影响力的科学肝胆病理生理学并改善本地和全球的肝脏健康和护理。