Applied Physiology and Tissue Mechanisms

应用生理学和组织机制

基本信息

批准号：
9545631
负责人：
ALICE S. RYAN
金额：
$ 22.7万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9545631
关键词：
Acute Adipose tissue Aerobic Aging American Biological Assay Biomedical Research Capsicum Cardiovascular Deconditioning Cardiovascular system Chronic Chronic Disease Chronic Kidney Failure Clinical Clinical Trials Collaborations Communities Consultations Development Elderly Eligibility Determination Endocrine Ensure Event Exercise Exercise stress test Faculty Functional disorder Funding Gene Expression Grant HIV-1 Hip Fractures Impairment Individual Inflammation Insulin Resistance Intervention Leadership Maryland Medical Mentors Metabolic Metabolic dysfunction Metabolic syndrome Metabolism Methodology Modality Molecular Muscle Musculoskeletal Obesity Outcome Paper Parkinson Disease Patient Recruitments Performance Peripheral arterial disease Physical Function Physiological Physiology Pilot Projects Population Prevention Prevention strategy Preventive Protocols documentation Publications Rehabilitation therapy Research Research Personnel Research Support Resistance Resources Risk Scientist Skeletal Muscle Standardization Stroke System Testing Tissues Training Translating Translational Research Translations United States National Institutes of Health Universities Vascular Endothelium Work base bench to bedside cardiometabolic risk cardiometabolism cardiovascular disorder risk cardiovascular fitness clinical phenotype design diabetes risk disability disabling disease disorder risk exercise intervention exercise rehabilitation exercise training falls fitness functional decline improved innovation laboratory experience metabolic phenotype mode of exercise multidisciplinary muscular structure novel patient safety programs protein expression rehabilitation science rehabilitation strategy research and development research study response restoration sarcopenia screening volunteer working group

项目摘要

7. Project Summary- Resource Core 2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, and acute events causing disability -- such as falls, stroke, and hip fracture -- occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The Applied Physiology and Tissue Mechanisms Resource Core’s (RC-2) hypothesis is that exercise and activity-based rehabilitation can improve multiple physiological systems in older, mobility-limited individuals, leading to improved functional performance, reduced cardiometabolic disease risk, and prevention of functional decline. This core focuses on the following specific aims: 1)To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive biomedical research in aging and disability across the UM-OAIC pilot projects, UM-OAIC scholars’ research, Development Projects (DPs), and external NIH and VA funded research; and 2)To provide research support, mentoring, and training to UM-OAIC scholars, junior faculty, and UM-OAIC researchers in the performance of aging research relevant to exercise and rehabilitation-based restoration of function and the prevention of functional declines in older people with chronic disabling diseases. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15-20 years. The characterization of the clinical and metabolic phenotype(s) of individuals with stroke, hip fracture, and other chronic disabling diseases in RC-2 have allowed UM-OAIC investigators to develop successful specific exercise rehabilitation strategies to improve functional and clinical outcomes. Thus this core, in collaboration with the other UM-OAIC cores, will continue to support innovative research studies examining the mechanisms and physiological effects of multisystem rehabilitation and preventive strategies on functional and physiological outcomes in older adults aging with chronic disabilities, with translation of these outcomes in novel clinical trials.

7. 项目总结 - 资源核心 2 心血管失调、慢性炎症和内分泌代谢功能障碍是人体固有的老年人由于慢性衰老疾病而受到身体损伤的病理生理学。肌肉减少症、体能不佳、炎症和导致残疾的急性事件，例如跌倒、中风和髋关节骨折——随着年龄的增长而发生，可能会增加活动能力并增加患心血管疾病的风险（CVD）和代谢异常。应用生理学和组织机制资源核心（RC-2）。假设是运动和基于活动的康复可以改善多个生理系统老年人、行动不便的人，可改善功能表现，降低心脏代谢疾病风险和功能衰退的预防该核心重点关注以下具体目标： 1) 促进肌肉骨骼和组织机械运动康复和预防的进行 UM-OAIC 试点项目中有关衰老和残疾的生物医学研究、UM-OAIC 学者的研究、开发项目 (DP) 以及外部 NIH 和 VA 资助的研究；以及 2) 提供研究支持，为 UM-OAIC 学者、初级教师和 UM-OAIC 研究人员提供以下方面的指导和培训：与基于运动和康复的功能恢复以及预防相关的衰老研究患有慢性致残疾病的老年人的功能下降。 RC-2 领导层和研究人员代表了一个由具有临床经验的基础科学家组成的多学科团队共同工作了 15-20 年的老年病学家临床和代谢的特征。 RC-2 中患有中风、髋部骨折和其他慢性致残疾病的个体的表型允许 UM-OAIC 研究人员制定成功的特定运动康复策略以改善功能因此，该核心将与其他 UM-OAIC 核心合作，继续提供支持。研究多系统康复的机制和生理效应的创新研究慢性病老年人功能和生理结果的预防策略残疾，并在新的临床试验中转化这些结果。