RR&D Research Career Scientist Award Application

RR

• 批准号: 10426424
• 负责人: ALICE S. RYAN
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426424
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My research focuses on developing and testing interventions to restore function and minimize disability following acute disabling events and to prevent declines related to serious chronic diseases. In addition, my work aims to advance our understanding of the mechanisms by which exercise and rehabilitation interventions directed at specific impairments affect body systems and tissues. My passion is also to train the next generation of investigators who will further the understanding of the aging process and develop interventions that help promote health and independence in older adults with disabling medical conditions. My work aligns well with the mission of Rehabilitation Research & Development (RR&D) and renewal of this Senior Research Career Scientist Award will allow me to continue this path. My entire career has been within the VA Maryland Health Care System with my first VA Merit awarded in 2001 Clinical Science Research & Development (CSR&D) and appointment as a VA Research Scientist, receipt of a NIH RO1 in 2001, and award of the Research Career Scientist (RCS) within CSR&D in 2004. During the first 5-years of the RCS, I was awarded a second VA Merit (CSR&D), a second NIH/RO1, and played an integral role in the receipt of three center grants where I was PI or co-investigator on research cores. During years 5-10 of the RCS, I obtained a third VA Merit (RR&D), a Merit Pilot Award (RR&D), was a co-investigator on four VA Merit Awards (CSR&D and RR&D), five NIH RO1 grants, two NIH-R awards, and led cores in three center grants. I was awarded a fourth VA Merit (RR&D) in 2015. During the SRCS which began in 2015, I was awarded a VA SPiRE (RR&D) in 2018, and fifth and sixth VA Merit Awards in 2019 and 2020 in RR&D and CSR&D, respectively. I was also awarded or a co-investigator on multiple NIH projects during this past cycle. I will be MPI in the renewal of the University of Maryland (UM) Claude D. Pepper Older Americans Independence Center (OAIC). My research career has thrived in this enriched research environment in collaboration with Veterans Affairs and University of Maryland M.D. and Ph.D. investigators. My leadership, independence, collegial attitude and collaborative nature serve to promote innovative patient-oriented research in preventive medicine, exercise rehabilitation, nutrition and aging in the VA Research Service, Baltimore GRECC, UM-OAIC, the Division of Gerontology and Palliative Medicine and in the past for the VA RR&D Center of Excellence, Exercise and Robotics in Neurological Disease and the Mid-Atlantic Nutrition and Obesity Research Center. I have enjoyed more recent opportunities to conduct multi-site clinical trials which further strengthen and expand the science in our goals to maximize independence in aging Veterans. I hold leadership positions within the Geriatrics, Research, Education & Clinical Centers (GRECC), have been a long-standing member of local VA committees (R&D and SRS), am a 13-year member of the Medicine Appointment, Promotions, Tenure (APT) Committee at UM, and have a continuous track record as member and chair of VA and NIH review panels. In my leadership positions, I promote and assist investigators in combined exercise and rehabilitation medicine interventions to examine changes in the cardiovascular and musculoskeletal systems and the link to function and mobility. Further, I have a successful history of training of junior scientists in becoming independent academic careers in exercise and rehabilitation science as a primary mentor of numerous postdoctoral fellows and upon receipt of their VA CDA or NIH K-Award. My commitment and joy in mentoring medical students, fellows and junior investigators in rehabilitation research continues to grow. I am indeed fortunate to have collaborators which cross so many disciplines including gerontology, exercise physiology, infectious disease, neurology, oncology, physical therapy, vascular surgery, radiology, pulmonology, and rheumatology. I am honored to have received the Senior Research Career Scientist and greatly appreciate the opportunity to renew this prestigious award.

我的研究重点是开发和测试干预措施以恢复功能并尽量减少残疾 发生急性致残事件后并预防与严重慢性疾病相关的衰退。另外，我的工作 旨在增进我们对运动和康复干预机制的理解 针对影响身体系统和组织的特定损伤。我的热情还在于培养下一代 研究人员将进一步了解衰老过程并制定干预措施以帮助 促进患有残疾疾病的老年人的健康和独立。我的工作与 康复研究与开发 (RR&D) 的使命以及高级研究生涯的更新 科学家奖将让我继续这条路。 我的整个职业生涯都在 VA 马里兰州医疗保健系统内进行，我的第一个 VA 优异奖于 2001 年临床科学研究与开发 (CSR&D) 并被任命为 VA 研究科学家，收据 2001 年荣获 NIH RO1 称号，并于 2004 年荣获 CSR&D 内的研究职业科学家 (RCS) 称号。 在 RCS 的第一个 5 年中，我获得了第二个 VA 优异奖 (CSR&D)、第二个 NIH/RO1，并获得了积分 我作为 PI 或核心研究联合研究员获得了三项中心资助。 5-10年期间 在 RCS 中，我获得了第三个 VA 优异奖 (RR&D)、优异飞行员奖 (RR&D)，是四项 VA 的联合研究员 优异奖（CSR&D 和 RR&D）、五项 NIH RO1 资助、两项 NIH-R 奖以及三项中心资助的领导核心。 2015 年，我获得了第四个 VA 优异奖 (RR&D)。在 2015 年开始的 SRCS 期间，我获得了 VA 奖 2018 年荣获 SPiRE (RR&D)，2019 年和 2020 年荣获 RR&D 和 CSR&D 第五届和第六届 VA 优异奖， 分别。在过去的这个周期中，我还获得了多个 NIH 项目的奖项或成为联合研究员。我将成为 MPI 马里兰大学 (UM) 克劳德·D·佩珀 (Claude D. Pepper) 美国老年人独立中心的更新 （OAIC）。我的研究生涯在这个丰富的研究环境中与退伍军人合作蓬勃发展 事务和马里兰大学医学博士和博士学位调查人员。我的领导力、独立性、合作态度 和协作性质有助于促进预防医学、运动领域以患者为中心的创新研究 退伍军人事务部研究服务处、巴尔的摩 GRECC、UM-OAIC、部门的康复、营养和老龄化 老年学和姑息医学以及过去为 VA RR&D 卓越、运动和 神经疾病机器人技术和中大西洋营养与肥胖研究中心。我已经享受过 最近有机会进行多地点临床试验，进一步加强和扩展了科学 我们的目标是最大限度地提高老年退伍军人的独立性。 我在老年病学、研究、教育和临床中心 (GRECC) 担任领导职务， 是当地 VA 委员会（研发和 SRS）的长期成员，是医学界的 13 年成员 UM 的任命、晋升、终身教职 (APT) 委员会，并拥有作为成员的连续记录 VA 和 NIH 审查小组主席。在我的领导职位上，我促进和协助调查人员结合 运动和康复医学干预措施，以检查心血管和肌肉骨骼的变化 系统以及与功能和移动性的联系。此外，我有培训初级科学家的成功历史 作为运动和康复科学的主要导师，成为独立的学术职业 许多博士后研究员，并在获得 VA CDA 或 NIH K-Award 后。我的承诺和喜悦 对康复研究方面的医学生、研究员和初级研究者的指导不断增加。 我确实很幸运能够拥有跨学科的合作者，包括老年学、 运动生理学、传染病学、神经病学、肿瘤学、物理治疗、血管外科、放射学、 肺病学和风湿病学。我很荣幸获得高级研究职业科学家和 非常感谢有机会续签这一享有声望的奖项。