RESOURCE CORE 2: APPLIED PHYSIOLOGY AND TISSUE MECHANISMS

资源核心 2：应用生理学和组织机制

基本信息

批准号：
8206006
负责人：
ALICE S. RYAN
金额：
$ 25.49万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8206006
关键词：
Acute Address Adipose tissue Aerobic Aging American Area Biological Assay Cardiovascular Deconditioning Cardiovascular system Chronic Chronic Disease Clinical Clinical Research Collaborations Communities Community Practice Comorbidity Development Disabled Persons Elderly Eligibility Determination Endocrine Ensure Event Exercise Exercise Physiology Faculty Functional disorder Funding Gene Expression Goals Grant HIV Hip Fractures Impairment Individual Inflammation Intervention Laboratories Lead Leadership Medical Medical Research Mentors Metabolic Metabolic syndrome Metabolism Methodology Molecular Molecular Biology Morbidity - disease rate Muscle Musculoskeletal Obesity Outcome Paper Parkinson Disease Performance Peripheral arterial disease Phenotype Physical Function Physiological Physiology Pilot Projects Population Prevention Prevention strategy Preventive Progress Reports Protocols documentation Publications Recovery of Function Rehabilitation therapy Research Research Personnel Research Support Resistance Resources Risk Scientist Screening procedure Skeletal Muscle Stroke System Testing Tissues Training Translating Translational Research United States National Institutes of Health Vascular Endothelium Work base cardiovascular disorder risk clinical practice design disability disabling disease fitness functional decline functional outcomes functional restoration improved innovation mortality motor learning multidisciplinary muscular structure novel patient safety prevent protein expression rehabilitation strategy response restoration sarcopenia standard of care volunteer working group

项目摘要

RC-2 Cardiovascular deconditioning, chronic inflammation, and endocrine-metabolic dysfunction are inherent to the pathophysiology of the physical impairments in older persons hindered by disabling chronic diseases of aging. Sarcopenia, poor fitness, inflammation, metabolic syndrome, and acute events related to disability, such as stroke and hip fracture, occur with advancing age and may worsen mobility and increase risk for cardiovascular disease (CVD) and metabolic abnormalities. The central hypothesis of RC-2 is that exercisefocused rehabilitation including aerobic and resistive training can improve multiple physiological systems in older, mobility limited individuals leading to improved functional performance, reduced cardiometabolic risk, and prevention of functional decline. This core focuses on the following specific aims: 1) To provide study support, mentor and train OAIC scholars, junior faculty and OAIC researchers in the performance of applied exercise physiology and tissue mechanisms research relevant to exercise-based restoration of function and prevention of functional declines in older people with chronic disabling diseases; 2) To facilitate the conduct of musculoskeletal and tissue mechanistic exercise rehabilitation and preventive medical research in aging and disability across the UM-OAIC pilot projects, RCDC Scholars' research and external NIH and VA funded research. We have combined two cores from our prior Pepper Centers into one more comprehensive core in this application that integrates bench and clinical research at the whole body and tissue level. RC-2 leadership and investigators represent a multidisciplinary team of basic scientists with clinical geriatricians who have worked together for 15 years. This core works synergistically with the other cores and research working groups to contribute to our fundamental understanding of the mechanisms by which exercise rehabilitation restores function, reduces metabolic risk and prevents functional decline in disabled individuals, as well as the mechanisms by which exercise rehabilitation enhances physical function and tissue metabolism.

RC-2 心血管失调、慢性炎症和内分泌代谢功能障碍是老年人因慢性致残疾病而造成的身体损伤的病理生理学老化。肌肉减少症、体质差、炎症、代谢综合征以及与残疾相关的急性事件，随着年龄的增长，例如中风和髋部骨折，可能会恶化活动能力并增加风险心血管疾病（CVD）和代谢异常。 RC-2 的中心假设是以运动为中心包括有氧训练和抗阻训练在内的康复可以改善多个生理系统老年人、行动不便的人可以改善功能表现，降低心脏代谢风险，和预防功能衰退。该核心重点关注以下具体目标： 1) 提供学习支持、指导和培训 OAIC 学者、初级教师和 OAIC 研究人员与运动相关的应用运动生理学和组织机制研究的表现患有慢性致残疾病的老年人的功能恢复和预防功能衰退； 2) 促进肌肉骨骼和组织机械运动康复和预防的进行 UM-OAIC 试点项目中有关老龄化和残疾的医学研究、RCDC 学者的研究和 NIH 和 VA 资助的外部研究。我们将之前 Pepper Centers 中的两个核心合并为一个更全面的核心。整合全身和组织水平的实验室和临床研究的应用程序。 RC-2 领导研究人员代表了一个由基础科学家和临床老年病学家组成的多学科团队，他们拥有一起工作了15年。该核心与其他核心和研究工作协同工作团体有助于我们对康复锻炼机制的基本理解恢复功能，降低代谢风险并防止残疾人的功能衰退，以及运动康复增强身体功能和组织代谢的机制。