Translational Research Training Program in Environmental Health Sciences

环境健康科学转化研究培训计划

• 批准号: 9385469
• 负责人: Trevor M Penning
• 金额: $ 0.53万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385469
• 关键词: Environmental Health; Training Programs; Translational Research

DESCRIPTION (provided by applicant) This is a resubmission of an application for a new Institutional Training Grant (T32) to support a Translational Research Training Program in Environmental Health Sciences for pre- and post- doctoral fellows at the University of Pennsylvania. The home for the Training Program will be the Center of Excellence in Environmental Toxicology (CEET) which is a P30 Environmental Health Sciences Core Center funded by NIEHS. The CEET is a Translational Environmental Health Sciences Center with a focus on major societal disease that affects the Philadelphia area: including but not limited to lung and airway disease, and reproductive, endocrinology, and developmental disorders (including the developmental basis of adult disease). Additionally, there is a strong emphasis on disease mechanism involving oxidative stress and gene-environment interactions. Pre-doctoral fellows, 2 per year, will be supported for three years bringing the steady state to 6 pre-doctoral fellows. Postdoctoral fellows preferably one Ph.D. and one M.D. will be appointed per year and will be supported for two years bringing the steady state to 4 postdoctoral fellows. Pre-doctoral fellows will be recruited to the investigators' umbrella program Biomedical Graduate Studies will be eligible to apply to the Certificate Program in Environmental Health Sciences which is a unique 2 year curriculum consisting of didactic course work and three rotations, one of which must be either a community-based research or population-based research rotation so that hands on training in environmental/molecular epidemiology is provided. Pre-doctoral fellows will be appointed to the Training Grant (TG) after completion of the first year of the Certificate Program. The training Program is distinct from the Certificate Program. All pre-doctoral fellows must take the Certificate Program but not all students in the Certificate Program will be supported by the Training Program. Those supported by the Training Program are expected to conduct thesis work in environmental health science that will be dual mentored by a basic and clinical scientist preceptor and will take additional course work in translational research training. Basic scientist postdoctoral fellows wishing to pursue clinical research on a disease of environmental etiology and clinician scientists wishing to pursue basic research on molecular and cellular mechanisms that lead to such disease will be appointed for up to two years. They will also be dual mentored. Postdoctoral fellows will be required to take at least four courses available to the Training Program pre-doctoral fellows to supplement their knowledge base. Postdoctoral fellows will also receive additional mentoring through the Career Development Core of the CEET. This Training Program provides the format for cross-fertilization and will provide a new cadre of environmental health scientist who may be equally well at home with the basic and clinical science of a problem. Trainees will be equipped to deal with environmental exposures, how they relate to disease and how their findings may be translated at the patient-, community- and public health- levels.

描述（由申请人提供） 这是重新提交新的机构培训补助金 (T32) 申请，以支持宾夕法尼亚大学博士前和博士后研究员的环境健康科学转化研究培训计划。培训计划的举办地点将是环境毒理学卓越中心 (CEET)，这是一个由 NIEHS 资助的 P30 环境健康科学核心中心。 CEET 是一个转化环境健康科学中心，重点研究影响费城地区的主要社会疾病：包括但不限于肺和气道疾病，以及生殖、内分泌和发育障碍（包括成人疾病的发育基础）。此外，还非常重视涉及氧化应激和基因-环境相互作用的疾病机制。每年 2 名博士前研究员将获得为期三年的支持，使博士前研究员的数量达到稳定的 6 名。博士后研究员最好是一名博士学位。每年将任命一名医学博士，并提供为期两年的支持，使博士后研究员数量达到稳定状态。 博士前研究员将被招募到研究人员的伞式计划中，生物医学研究生将有资格申请环境健康科学证书计划，这是一个独特的 2 年课程，包括教学课程和三轮轮换，其中一次必须是基于社区的研究或基于人群的研究轮换，以便提供环境/分子流行病学方面的实践培训。 博士前研究员将在完成第一年的证书课程后获得培训补助金（TG）。 培训计划与证书计划不同。 所有博士前研究员都必须参加证书课程，但并非所有参加证书课程的学生都会获得培训计划的支持。那些受到培训计划支持的人预计将在环境健康科学领域开展论文工作，这些论文将由基础科学家和临床科学家导师双重指导，并将参加转化研究培训的额外课程。 基础科学家 希望对环境病因学疾病进行临床研究的博士后研究员和希望对导致此类疾病的分子和细胞机制进行基础研究的临床科学家的任命期限最长为两年。他们还将受到双重指导。博士后研究员将被要求至少参加培训计划博士前研究员可用的四门课程，以补充他们的知识库。博士后研究员还将通过 CEET 的职业发展核心获得额外的指导。 该培训计划提供了交叉受精的形式，并将提供一支新的环境健康科学家骨干队伍，他们可能同样熟悉问题的基础科学和临床科学。 学员将具备处理环境暴露、环境暴露与疾病的关系以及如何将他们的发现转化为患者、社区和公共卫生层面的能力。