17th Int. Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism

第 17 届国际。

基本信息

批准号：
8719700
负责人：
Trevor M Penning
金额：
$ 1万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-05-15 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8719700
关键词：
Alcohol abuse Alcohol consumption Alcohol dehydrogenase Alcoholism Alcohols Aldehydes Area Bioinformatics Biological Clinical Collaborations Communication Diabetes Mellitus Discipline Disease Educational workshop Endocrinologist Enzymatic Biochemistry Enzymes Epidemiology Ethanol toxicity Family Fertilization Focus Groups Fostering Funding Gene Proteins Genes Germany Goals Grant Health Human Individual Inherited International Ketones Kinetics Knock-in Mouse Knock-out Knowledge Learning Ligands Lipid Peroxidation Metabolic Metabolic Pathway Metabolism Molecular Biology Molecular Profiling Mutation Nomenclature Nuclear Receptors Oral Orphan Outcome Oxidoreductase Participant Pathogenesis Pennsylvania Phenotype Physiological Play Population Genetics Postdoctoral Fellow Protein Family Proteomics Publishing Recording of previous events Regulator Genes Research Research Personnel Retinoids Role Scientist Senior Scientist Structural Biologist Structure Switzerland Toxic Environmental Substances Toxic effect Travel Work Xenobiotics aldehyde dehydrogenases base carbonyl group carcinogenesis cost detoxication experience frontier functional genomics functional group medical specialties meetings member metabolomics novel posters pre-doctoral predoctoral investigator programs public health relevance steroid hormone structural biology symposium transcriptome sequencing tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): This R13 Conference Grant is being submitted to support the 17th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism to be held in Pennsylvania between, July 8- July 12, 2014. The workshop takes place biannually alternating between a foreign and US venue. The workshop was last held in US in 2010 and thus four years have passed since US attendees have had easy access to the meeting. The focus of the meeting is on the four major enzyme superfamilies involved in the metabolism and detoxication of carbonyl containing substrates: the alcohol dehydrogenases (ADH); the aldehyde dehydrogenases (ALDH), the short-chain dehydrogenase/reductases (SDRs); and the aldo-keto reductases (AKRs). The first two families are intimately involved in the metabolism and toxicity resulting from ethanol ingestion; and all four families play roles in the elimination of toxic aldehydes and ketones. Each family is introduced followed by an in-depth discussion of structure-function and mechanistic enzymology. The roles of individual members of each superfamily are then discussed in terms of health and disease. This includes roles in: alcohol abuse and alcoholism; metabolism of by-products of lipid peroxidation; metabolism of ligands for nuclear receptors (e.g. retinoids, steroid hormones); and roles in diabetes, carcinogenesis and oncogenesis. The application of modern approaches including bioinformatics, functional genomics, gene knock-out and knock-in, expression profiling and proteomics and metabolomics will be emphasized. The Conference attracts senior scientists who are expert in their respective fields but new investigators are encouraged to attend along with pre- and post-doctoral fellows. Every attendee has the opportunity to present either orally or in poster format. This application is solely to support the travel of trainees. It is the cultur of the meeting that there are no invited speakers who are paid to attend. Rather senior scientists pay their own way. This keeps meeting costs down and with sponsorship allows the organizers to invest all funds to offset the travel of the trainees. No other conference exists which brings investigators in these fields together. The workshop has a rich history of making unique contributions: gene/protein family nomenclature takes its origins from the workshop and over half the participants have either collaborated or published together as a result of participating i one or more conferences. We anticipate 100-120 attendees to attend the 4.5 day conference with nearly one half being trainees. We seek support for at least 20 trainees to attend the conference.

描述（由申请人提供）：此 R13 会议拨款用于支持将于 2014 年 7 月 8 日至 7 月 12 日在宾夕法尼亚州举行的第 17 届国际羰基代谢酶学和分子生物学研讨会。该研讨会每两年交替举行一次在外国和美国场地之间。该研讨会上一次在美国举行是在 2010 年，距离美国与会者能够轻松参加会议已经过去四年了。会议的重点是参与含羰基底物代谢和解毒的四个主要酶超家族：乙醇脱氢酶（ADH）；醛脱氢酶 (ALDH)、短链脱氢酶/还原酶 (SDR)；和醛酮还原酶（AKR）。前两个家族与乙醇摄入引起的代谢和毒性密切相关。所有四个家族都在消除有毒醛和酮方面发挥作用。介绍每个家族，然后深入讨论结构功能和机械酶学。然后从健康和疾病的角度讨论每个超家族个体成员的作用。这包括以下角色：酗酒和酗酒；脂质过氧化副产物的代谢；核受体配体的代谢（例如类维生素A、类固醇激素）；以及在糖尿病、癌变和肿瘤发生中的作用。将强调现代方法的应用，包括生物信息学、功能基因组学、基因敲除和敲入、表达谱以及蛋白质组学和代谢组学。会议吸引了各自领域专家的资深科学家，但鼓励新研究人员与博士前和博士后研究员一起参加。每位与会者都有机会进行口头或海报形式的展示。此应用程序仅用于支持学员的旅行。会议的文化是没有受邀演讲者付费参加。相反，资深科学家们自己付出代价。这可以降低会议成本，并且通过赞助，组织者可以投入所有资金来抵消学员的差旅费。没有其他会议可以将这些领域的研究人员聚集在一起。该研讨会有着做出独特贡献的丰富历史：基因/蛋白质家族命名法起源于该研讨会，超过一半的参与者因参加一个或多个会议而合作或共同发表论文。我们预计将有 100-120 名与会者参加为期 4.5 天的会议，其中近一半是学员。我们寻求支持至少 20 名学员参加会议。