MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN

光纤探头设计的蒙特卡罗方法

• 批准号: 8169490
• 负责人: VASAN VENUGOPALAN
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169490
• 关键词: Caliber; Cancer Detection; Collection; Computer Retrieval of Information on Scientific Projects Database; Development; Endoscopes; Epithelial; Epithelium; Fiber; Fiber Optics; Funding; Goals; Grant; Human; Institution; Lead; Lighting; Malignant Neoplasms; Monitor; Monte Carlo Method; Morphology; Optics; Property; Reporting; Research; Research Personnel; Resolution; Resources; Source; Spectrum Analysis; Testing; Time; United States National Institutes of Health; carcinogenesis; design; detector; in vivo; instrument; novel; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this project is to use Monte Carlo simulations in development of novel fiber optic endoscopes that can simultaneously probe the epithelial and stromal morphology using oblique collection fiber geometry. We will use previously reported scattering properties of human epithelium to predict and to characterize collection efficiency and depth resolution of different probe designs. Design parameters will include source-detector separation; various angles between illumination and collection fibers; fiber diameter; number of collection fibers, etc. We will change optical properties of the epithelium to reflect early cancer development and will optimize probe design to achieve the highest sensitivity to optical changes that are associated with an onset of carcinogenesis. Theoretical predictions will be tested using well defined multi-layered optical phantoms of human epithelium. Successful completion of the project can lead to development of a simple instrument for non-invasive, real time in vivo pre-cancer detection and monitoring via reflectance spectroscopy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的主要目的是使用蒙特卡洛模拟来开发新型的纤维内窥镜，这些内镜可以同时使用倾斜收集纤维几何形状探测上皮和基质形态。我们将使用先前报道的人上皮的散射特性来预测和表征不同探针设计的收集效率和深度分辨率。设计参数将包括源检测器分离；照明和收集纤维之间的各种角度；纤维直径；收集纤维等的数量等。我们将改变上皮的光学特性，以反映早期癌症的发展，并将优化探针设计，以实现与癌变有关的光学变化的最高敏感性。理论预测将使用人类上皮的良好定义的多层光学幻象进行测试。成功完成该项目可能会导致开发一种简单的仪器，用于通过反射光谱进行体内前癌症检测和监测的非侵入性实时仪器。