PERTURBATION MONTE CARLO TECHNIQUES FOR DIFFUSE PHOTON MIGRATION

漫射光子迁移的扰动蒙特卡洛技术

• 批准号: 8362599
• 负责人: VASAN VENUGOPALAN
• 金额: $ 0.47万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362599
• 关键词: Algorithms; Biotechnology; Complex; Development; Diffuse; Funding; Grant; Heterogeneity; Lasers; Methods; National Center for Research Resources; Optics; Photons; Principal Investigator; Property; Research; Research Infrastructure; Resources; Signal Transduction; Solutions; Source; Techniques; Tissues; United States National Institutes of Health; cost; migration; novel; simulation; Algorithms; Biotechnology; Complex; Development; Diffuse; Funding; Grant; Heterogeneity; Lasers; Methods; National Center for Research Resources; Optics; Photons; Principal Investigator; Property; Research; Research Infrastructure; Resources; Signal Transduction; Solutions; Source; Techniques; Tissues; United States National Institutes of Health; cost; migration; novel; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development has continued of a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then supply the derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under consideration. We have demonstrated this approach in two layered media as well as more complex tissue geometries descriptive of particular applications.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 开发继续采用了一种新颖而有效的方法，可以为异构浊度培养基中的逆光子迁移问题提供解决方案。该方法从单个蒙特卡洛模拟中提取衍生信息，以允许在背景组织光学特性中快速确定检测到的光子信号的变化速率。然后，我们将衍生信息提供给非线性优化算法，以确定所考虑的组织异质性的光学特性。我们已经在两种分层介质以及更复杂的组织几何形状描述了特定应用中证明了这种方法。