MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN

光纤探头设计的蒙特卡罗方法

基本信息

批准号：
8362661
负责人：
VASAN VENUGOPALAN
金额：
$ 0.45万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8362661
关键词：
Biotechnology Caliber Cancer Detection Collection Development Endoscopes Epithelial Epithelium Fiber Fiber Optics Funding Goals Grant Human Lasers Lead Lighting Malignant Neoplasms Monitor Monte Carlo Method Morphology National Center for Research Resources Optics Principal Investigator Property Reporting Research Research Infrastructure Resolution Resources Source Spectrum Analysis Testing Time United States National Institutes of Health carcinogenesis cost design detector in vivo instrument novel simulation

Biotechnology Caliber Cancer Detection Collection Development Endoscopes Epithelial Epithelium Fiber Fiber Optics Funding Goals Grant Human Lasers Lead Lighting Malignant Neoplasms Monitor Monte Carlo Method Morphology National Center for Research Resources Optics Principal Investigator Property Reporting Research Research Infrastructure Resolution Resources Source Spectrum Analysis Testing Time United States National Institutes of Health carcinogenesis cost design detector in vivo instrument novel simulation

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The main goal of this project is to use Monte Carlo simulations in development of novel fiber optic endoscopes that can simultaneously probe the epithelial and stromal morphology using oblique collection fiber geometry. We will use previously reported scattering properties of human epithelium to predict and to characterize collection efficiency and depth resolution of different probe designs. Design parameters will include source-detector separation; various angles between illumination and collection fibers; fiber diameter; number of collection fibers, etc. We will change optical properties of the epithelium to reflect early cancer development and will optimize probe design to achieve the highest sensitivity to optical changes that are associated with an onset of carcinogenesis. Theoretical predictions will be tested using well defined multi-layered optical phantoms of human epithelium. Successful completion of the project can lead to development of a simple instrument for non-invasive, real time in vivo pre-cancer detection and monitoring via reflectance spectroscopy.

该副本是利用资源的众多研究子项目之一由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持而且，副投影的主要研究员可能是其他来源提供的包括其他NIH来源。列出的总费用可能代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。该项目的主要目的是使用蒙特卡洛模拟来开发新型的纤维内窥镜，这些内镜可以同时使用倾斜收集纤维几何形状探测上皮和基质形态。我们将使用先前报道的人上皮的散射特性来预测和表征不同探针设计的收集效率和深度分辨率。设计参数将包括源检测器分离；照明和收集纤维之间的各种角度；纤维直径；收集纤维等的数量等。我们将改变上皮的光学特性，以反映早期癌症的发展，并将优化探针设计，以实现与癌变有关的光学变化的最高敏感性。理论预测将使用人类上皮的良好定义的多层光学幻象进行测试。成功完成该项目可能会导致开发一种简单的仪器，用于通过反射光谱进行体内前癌症检测和监测的非侵入性实时仪器。