POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA

Poise：一种确定浑浊介质光学特性的新方法

• 批准号: 8362621
• 负责人: VASAN VENUGOPALAN
• 金额: $ 2.93万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362621
• 关键词: Agreement; Biotechnology; Frequencies; Funding; Grant; Imaging Techniques; Lasers; Measurement; Measures; Methods; Modeling; National Center for Research Resources; Optics; Photons; Physiologic pulse; Principal Investigator; Property; Research; Research Infrastructure; Resolution; Resources; Sampling; Source; Surface; System; Techniques; Time; United States National Institutes of Health; absorption; cost; instrument; irradiation; migration; novel strategies; tissue phantom

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns. The absorption and reduced scattering coefficients are determined by fitting the POISe measurement to model functions that describe the time-resolved surface deformation as a function of optical and thermophysical properties of the target. We present the capabilities of the instrument and a few preliminary results of the POISe system used to determine the optical properties of two homogeneous, turbid tissue phantoms. We show that the absorption and reduced scattering coefficients estimated by POISe are in relatively good agreement with those derived through the more established method of frequency domain photon migration (FDPM).

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 Porise是一种通过用短（<10 ns）激光脉冲照射后测量其表面位移来进行成像和/或确定浊度样品的光学特性的技术。该技术是通过修改的Mach-Zehnder干涉仪启用的，能够测量以0.5 nm的轴向精度测量表面位移，而时间分辨率为4 ns。 吸收和减少散射系数由 将平衡测量拟合到描述的模型功能 时间分辨的表面变形作为光学和 目标的热物理特性。 我们介绍乐器的功能和一些初步 固定系统的结果用于确定的光学特性 两个均匀的浑浊的组织幻影。我们表明吸收和 通过平衡估计的散射系数减少相对较好 与更确定的方法衍生的人的一致 频域光子迁移（FDPM）。