EFFECTS OF PDT & GAMMA RADIATION ON HUMAN GLIOMA SPHEROIDS

光动力治疗的效果

• 批准号: 8169429
• 负责人: Bruce J. Tromberg
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169429
• 关键词: California; Clinic; Computer Retrieval of Information on Scientific Projects Database; Dose; Esters; Fever; Funding; Gamma Rays; Glioblastoma; Glioma; Grant; Health Physics; Human; Institutes; Institution; Investigation; Ionizing radiation; Lasers; Malignant neoplasm of brain; Medical; Nevada; Norway; Pathology; Photochemotherapy; Photosensitizing Agents; Publications; Radium; Research; Research Personnel; Research Project Grants; Resources; Source; Surgical Oncology; Temperature; United States; United States National Institutes of Health; Universities; light effects; neurosurgery; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this research project is to investigate the utility of photodynamic therapy (PDT) for the treatment of malignant brain tumors (gliomas). The project is a close and integrated multi disciplinary collaborative effort of various institutions in he United States and Norway. The participating parties are: The Department of neurosurgery, Rikshospital, the Laser microbeam and medical program (LAMMP) facility at the Beckman Laser Institute and Medical Clinic (BLI), University of California, Irvine (UCI), California USA the Department of health physics at the University of Nevada, Las Vegas (UNLV), Nevada USA. and the Departments of surgical oncology, and pathology the Norwegian Radium Hospital.Oslo Norway. The aim of previous investigations was to determine the utility of photodynamic therapy in combination with ionizing radiation or concurrent hyperthermia in the treatment of glioblastoma multiforme. The effects of light dose, gamma radiation dose, temperature and photosensitizer type on human glioma spheroids have been investigated in detail. The project also investigated the PDT effect of ALA-ester and repetitive PDT treatments during the past few years with several publications resulted from the study.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 该研究项目的总体目的是研究光动力疗法（PDT）对治疗恶性脑肿瘤（Gliomas）的实用性。 该项目是美国和挪威的各个机构的紧密而综合的多学科合作努力。参与方是：贝克曼激光研究所和加利福尼亚大学欧文分校（UCI）的贝克曼激光研究所和医学诊所（UCI）的贝克曼激光研究所和医学诊所（UCI）的神经外科部，LASER MICROBEAS和医疗计划（LAMMP）设施在内华达州内华达州内华达州内华达大学的内华达大学。以及手术肿瘤学的部门和病理学的挪威镭医院。 先前研究的目的是确定光动力疗法与电离辐射或并发性高温治疗多形胶质母细胞瘤的效用。 已经详细研究了光剂量，γ辐射剂量，温度和光敏剂类型对人胶质瘤球体的影响。 该项目还调查了过去几年中Ala-Ester和重复PDT治疗的PDT效应，并研究了该研究的几份出版物。