INTRAOPERATIVE OPTICAL IMAGING FOR NEUROSURGICAL GUIDANCE

用于神经外科指导的术中光学成像

• 批准号: 8362614
• 负责人: Bruce J. Tromberg
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362614
• 关键词: Affect; Biotechnology; Brain Neoplasms; Craniotomy; Development; Diagnosis; Excision; Funding; Goals; Grant; Image; Lasers; Length; National Center for Research Resources; Nervous System Trauma; Neurologic; Operative Surgical Procedures; Optics; Patients; Principal Investigator; Procedures; Quality of life; Research; Research Infrastructure; Resources; Source; Techniques; Therapeutic; Tissues; United States National Institutes of Health; brain tumor resection; cost; follow-up; optical imaging; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Surgical removal of brain tumors is the most common initial treatment received by brain tumor patients. Surgical resection can benefit the patients in several ways: for example, it relieves the mass effect of tumor on neurological tissue and allows histological diagnosis of the tumor, which directly affects the direction of follow-up therapeutic strategy (3). Many studies have demonstrated that aggressive surgical resection enhances the survival length and quality of life for brain tumor patients. Therefore, the goal of brain tumor resection procedures is to maximize tumor removal with minimal neurological damage. To achieve this goal accurate intraoperative identification of brain tumor margins during craniotomy is required. This study aims at the development of a means for visualizing brain tumor margins using optical techniques such as Modulated Imaging.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 脑肿瘤的手术切除是脑肿瘤患者接受的最常见初始治疗方法。手术切除可以通过多种方式使患者受益：例如，它可以减轻肿瘤对神经组织的质量影响，并允许对肿瘤的组织学诊断，这直接影响了随访治疗策略的方向（3）。许多研究表明，侵略性手术切除可增强脑肿瘤患者的生存时间和生活质量。因此，脑肿瘤切除程序的目的是最大程度地清除肿瘤，而神经系统损害最小。为了实现此目标，需要在颅骨切开术期间对脑肿瘤边缘进行准确的术中鉴定。这项研究旨在开发一种使用光学技术（例如调制成像）可视化脑肿瘤边缘的方法。