GENES, ENVIRONMENTS, & ADMIXTURE IN LATINO ASTHMATICS (GALA II) STUDY

基因、环境、

• 批准号: 8166741
• 负责人: HAROLD J FARBER
• 金额: $ 0.19万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166741
• 关键词: Acculturation; Admixture; African; Age; Asthma; California; Candidate Disease Gene; Case-Control Studies; Central American; Chicago; Clinic; Complex; Computer Retrieval of Information on Scientific Projects Database; Disease susceptibility; Dominican; Enrollment; Environment; Environmental Risk Factor; Epidemiology; European; Funding; Genes; Genetic; Genotype; Grant; Individual; Institution; Laboratories; Latino; Mexican; Morbidity - disease rate; Native Americans; Phenotype; Prevalence; Puerto Rican; Puerto Rico; Recruitment Activity; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; San Francisco; Site; Source; Testing; United States National Institutes of Health; Universities; base; migration; mortality; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is caused by the interaction of genetic and environmental factors. In the U.S., asthma prevalence, morbidity and mortality are highest in Puerto Ricans, intermediate in Dominicans and Cubans, and lowest in Mexicans and Central Americans. Latinos are admixed and share varying proportions of African, Native American and European ancestry. The mixed ancestry of Latinos provides unique opportunities in epidemiological and genetic studies of complex traits and may be useful in untangling complex gene-environment (G x E) interactions in disease susceptibility. We will collect a well-characterized sample of Latino individuals with asthma (n = 2000) and clinic-based controls (n = 2000), age 8-21 years, from the Bronx, NY, Chicago, IL, San Francisco, CA, Houston, TX, and Puerto Rico 1) Test the hypothesis that genetic ancestry interacts with environmental/demographic risk factors to modify asthma risk and asthma-related phenotypes. 2) Genotype fifty candidate genes that may be involved in G x E interactions relevant to asthma. 3) Determine whether migration and acculturation are associated with asthma and severe asthma. Case control study with the objective of collecting a well-characterized sample of Latino asthmatics (n = 2000) and clinic-based controls (n = 2000), age 8-21 years, from the Bronx, NY, Chicago, IL, San Francisco, CA, Houston, TX and Puerto Rico. The Houston site will be responsible for recruiting and enrolling 400 cases and 400 control subjects over a 3 year period. The genetics laboratory will be at University of California, San Francisco We will collect a well-characterized sample of Latino individuals with asthma (n = 2000) and clinic-based controls (n = 2000), age 8-21 years, from the Bronx, NY, Chicago, IL, San Francisco, CA, Houston, TX, and Puerto Rico from which the specific hypotheses described above can be tested. The Houston site will be responsible for recruiting 400 cases and 400 controls over a 3 year period.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 哮喘是由遗传和环境因素的相互作用引起的。在美国，波多黎各人，多米尼加人和古巴人中间的哮喘患病率，发病率和死亡率最高，在墨西哥人和中美洲人中最低。拉丁美洲人被混合并分享了不同比例的非洲，美洲原住民和欧洲血统。拉丁美洲人的混合血统在复杂性状的流行病学和遗传研究中提供了独特的机会，并且可能在疾病易感性中脱离疾病的复杂基因环境（G x e）相互作用方面有用。 我们将收集一个哮喘（n = 2000）和基于诊所的对照（n = 2000）的拉丁裔个体，年龄8-21岁，来自纽约州纽约州，芝加哥，伊利诺伊州，伊利诺伊州，旧金山，加利福尼亚州，加利福尼亚州，加利福尼亚州芝加哥，8-21岁德克萨斯州休斯顿和波多黎各 1）检验遗传血统与环境/人口统计学风险因素相互作用以改变哮喘风险和与哮喘相关的表型相互作用的假设。 2）可能与哮喘相关的G X E相互作用的基因型五十种候选基因。 3）确定迁移和适应是否与哮喘和严重哮喘有关。 案例控制研究的目的是收集良好的拉丁裔哮喘患者（n = 2000）和基于诊所的对照（n = 2000），年龄8-21岁，来自纽约州，纽约州，芝加哥，伊利诺伊州，旧金山，旧金山，加利福尼亚州休斯顿，德克萨斯州和波多黎各。休斯顿站点将在3年期间负责招募和注册400例和400名对照对象。 遗传学实验室将在加利福尼亚大学旧金山分校 我们将收集一个哮喘（n = 2000）和基于诊所的对照（n = 2000）的拉丁裔个体，年龄8-21岁，来自纽约州纽约州，芝加哥，伊利诺伊州，伊利诺伊州，旧金山，加利福尼亚州，加利福尼亚州，加利福尼亚州芝加哥，8-21岁德克萨斯州休斯顿和波多黎各，可以测试上述特定假设。 休斯顿站点将在3年期间招募400例案件和400个对照。