EFFECTS OF PDT & GAMMA RADIATION ON HUMAN GLIOMA SPHEROIDS

光动力治疗的效果

• 批准号: 7954755
• 负责人: Bruce J. Tromberg
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954755
• 关键词: Biotechnology; California; Clinic; Computer Retrieval of Information on Scientific Projects Database; Dose; Esters; Fever; Funding; Gamma Rays; Glioblastoma; Glioma; Grant; Health Physics; Human; Institutes; Institution; Investigation; Ionizing radiation; Lasers; Malignant neoplasm of brain; Medical; Nevada; Norway; Pathology; Photochemotherapy; Photosensitizing Agents; Publications; Radium; Research; Research Personnel; Research Project Grants; Resources; Source; Surgical Oncology; Temperature; United States; United States National Institutes of Health; Universities; light effects; neurosurgery; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall objective of this research project is to investigate the utility of photodynamic therapy (PDT) for the treatment of malignant brain tumors (gliomas). The project is a close and integrated multi disciplinary collaborative effort of various institutions in he United States and Norway. The participating parties are: The Department of neurosurgery, Rikshospital, the Laser microbeam and medical program (LAMMP) facility at the Beckman Laser Institute and Medical Clinic (BLI), University of California, Irvine (UCI), California USA the Department of health physics at the University of Nevada, Las Vegas (UNLV), Nevada USA. and the Departments of surgical oncology, and pathology the Norwegian Radium Hospital.Oslo Norway. The aim of previous investigations was to determine the utility of photodynamic therapy in combination with ionizing radiation or concurrent hyperthermia in the treatment of glioblastoma multiforme. The effects of light dose, gamma radiation dose, temperature and photosensitizer type on human glioma spheroids have been investigated in detail. The project also investigated the PDT effect of ALA-ester and repetitive PDT treatments during the past few years with several publications resulted from the study.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究项目的总体目标是研究光动力疗法（PDT）在治疗恶性脑肿瘤（神经胶质瘤）中的效用。 该项目是美国和挪威各机构密切、综合的多学科合作成果。参与方包括：国立医院神经外科、贝克曼激光研究所和医学诊所 (BLI) 的激光微束和医疗项目 (LAMMP) 设施、美国加利福尼亚州加州大学欧文分校 (UCI)、健康物理系内华达大学拉斯维加斯分校 (UNLV)，美国内华达州。以及挪威奥斯陆挪威镭医院的肿瘤外科和病理科。 先前研究的目的是确定光动力疗法联合电离辐射或同时热疗在治疗多形性胶质母细胞瘤中的效用。 详细研究了光剂量、伽马辐射剂量、温度和光敏剂类型对人胶质瘤球体的影响。 该项目还研究了过去几年 ALA-酯和重复 PDT 治疗的 PDT 效果，并发表了几篇研究成果。