2015 Translation Machinery in Health & Disease Gordon Research Conference

2015年健康翻译机

• 批准号: 8831351
• 负责人: Xiang-Lei Yang
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8831351
• 关键词: Academia; Address; Amino Acyl-tRNA Synthetases; Anemia; Area; Autoimmune Process; Autoimmunity; Bacterial Infections; Basic Science; Biological; Biology; Biotechnology; California; Cell physiology; Cells; Clinic; Clinical; Code; Collaborations; Communicable Diseases; Complex; Development; Diabetes Mellitus; Discipline; Disease; Elements; Fill-It; Goals; Health; Hematological Disease; Human; Immune System Diseases; Industry; Maintenance; Malignant Neoplasms; Metabolic Diseases; Minority; Mitochondrial Diseases; Myositis; Nerve Degeneration; Nucleic Acids; Organism; Participant; Pathologic Processes; Pharmacologic Substance; Physiological; Process; Protein Biosynthesis; Proteins; Regulation; Request for Applications; Research; Research Personnel; Ribosomal Proteins; Ribosomes; Role; Scientist; Series; Structure; System; Time; Transfer RNA; Translation Alteration; Translations; Vascular Diseases; Virus Diseases; Woman; Work; genetic information; human disease; innovation; interest; lectures; meetings; nervous system disorder; novel; posters; public health relevance; symposium; therapeutic development; translation factor; Academia; Address; Amino Acyl-tRNA Synthetases; Anemia; Area; Autoimmune Process; Autoimmunity; Bacterial Infections; Basic Science; Biological; Biology; Biotechnology; California; Cell physiology; Cells; Clinic; Clinical; Code; Collaborations; Communicable Diseases; Complex; Development; Diabetes Mellitus; Discipline; Disease; Elements; Fill-It; Goals; Health; Hematological Disease; Human; Immune System Diseases; Industry; Maintenance; Malignant Neoplasms; Metabolic Diseases; Minority; Mitochondrial Diseases; Myositis; Nerve Degeneration; Nucleic Acids; Organism; Participant; Pathologic Processes; Pharmacologic Substance; Physiological; Process; Protein Biosynthesis; Proteins; Regulation; Request for Applications; Research; Research Personnel; Ribosomal Proteins; Ribosomes; Role; Scientist; Series; Structure; System; Time; Transfer RNA; Translation Alteration; Translations; Vascular Diseases; Virus Diseases; Woman; Work; genetic information; human disease; innovation; interest; lectures; meetings; nervous system disorder; novel; posters; public health relevance; symposium; therapeutic development; translation factor

 DESCRIPTION (provided by the applicant): This application requests partial support for a meeting on Translation Machinery in Health & Disease - Protein Synthesis and Beyond as part of the Gordon Research Conference series to be held in Ventura, California, on February 22-27, 2015. This Conference is a new GRC and the first disease-focused, interdisciplinary conference for the broad field of translation. The conference fills a niche that is not addressed by any existing conferences on translation and the translation machinery, which mainly focus on structures of the translation machinery, and its specific functions and regulations in protein synthesis, and not on the "new biology" of this same machinery, the pathological consequence of an altered translation apparatus, or on how translation regulates diverse systems in humans. However, GRC presently has no meeting devoted to translation per se. This circumstance provides an excellent opportunity to develop, under the auspices of the GRC, a new conference to bridge translation to health and disease. The broad and long-term goal of the conference is to deepen our understanding of translation and its connection to health and disease, and to open doors to developing novel treatments and therapies. The conference will cover many disease areas including cancer, neurological diseases, immunological diseases, infectious diseases, hematological and vascular diseases, metabolic diseases, and mitochondrial diseases. The conference will present for the first time a forum for clinicians and basic scientists to discuss their distinct but overlapping interests in these translation-related molecules and diseases. The specific aims of this meeting are to convene 38-46 leading experts that cover critical basic science and clinical topics, with a total of 150 participants, for a five-day meeting. The meeting will be organized into nine sessions including an opening session on the first day featuring 2 keynote lectures, followed by 8 sessions that each focus on a specific disease area. Four additional keynote lectures will start each day for the remaining 4 days of the conference, to provide high-level introductions on topics that are relevant for the day's sessions. The keynote lectures will be given by Drs. Ada Yonath, Paul Schimmel, Nahum Sonenberg and Jonathan Weissman, with two more to be announced. Among them, Dr. Yonath is a Nobel laureate best known for her groundbreaking work on the structure and function of ribosomes; Dr. Schimmel is the most renowned scientist in the tRNA synthetase field, and an entrepreneur who has transferred basic science into therapies through many successful biotechnology companies that he has founded. In addition, four afternoon poster sessions will permit all participants to contribute to the meeting. As with all Gordon Conferences there will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. As the first disease-focused conference for the field of translation, this conference would significantly impact our understanding of many important diseases-such as autoimmune myositis, cancer, neurodegeneration, diabetes, anemia, and viral and bacterial infections-and their treatment.

 描述（由应用程序提供）：本申请要求对健康与疾病的翻译机械进行部分支持 - 蛋白质合成，以及将于2015年2月22日至27日在加利福尼亚州文图拉举行的Gordon Research Conference系列的一部分。该会议是新的GRC，是新的GRC，是第一次以疾病为中心的疾病，跨学科的跨学科会议，用于广泛的翻译领域。 The conference fills a niche that is not addressed by any existing conferences on translation and the translation machinery, which mainly focus on structures of the translation machinery, and its specific functions and regulations in protein synthesis, and not on the "new biology" of this same machinery, the pathological consequence of an altered translation apparatus, or on how translation regulates divers systems in humans.但是，GRC目前没有专门用于翻译本身的会议。在GRC的主持下，提供了一个绝佳的机会，这是一个新的会议，将转化为健康和疾病的新会议。会议的广泛和长期目标是加深我们对翻译及其与健康和疾病的联系，并为开发新型治疗和疗法的大门打开大门。该会议将涵盖许多疾病领域，包括癌症，神经系统疾病，免疫疾病，传染病，血液学和血管疾病，代谢性疾病以及线粒体疾病。该会议将首次举行一个论坛，供临床医生和基础科学家讨论他们在这些与翻译有关的分子和疾病中的独特但​​重叠的兴趣。这次会议的具体目标是方便38-46名领先的专家，涵盖批判基础科学和临床主题，共有150名参与者在为期五天的会议上。这次会议将在九次会议上组织，其中包括在第一天举行的开幕式，其中包括2次主题演讲，然后进行8次会议，每个会议都集中在特定的疾病领域。在会议的剩余4天，每天将开始四次主题演讲，以提供与当天会议有关的主题的高级介绍。主题演讲将由Drs进行。 Ada Yonath，Paul Schimmel，Nahum Sonenberg和Jonathan Weissman，还有两个要宣布。其中，Yonath博士是诺贝尔奖获得者，以其核糖体的结构和功能开创性的作品而闻名。 Schimmel博士是TRNA合成酶领域中最著名的科学家，也是通过他创立的许多成功的生物技术公司将基础科学转移到疗法中的企业家。此外，四个下午的海报会议将允许所有参与者为会议做出贡献。与所有戈登会议一样，年轻的调查员，妇女和少数民族将有很多机会与该领域的高级领导人互动。作为 这次会议以疾病为重点的翻译领域会议将严重影响我们对许多重要疾病的理解，例如自身免疫性肌炎，癌症，神经退行性，糖尿病，贫血以及病毒和细菌感染以及治疗。