2015 Translation Machinery in Health & Disease Gordon Research Conference

2015年健康翻译机

• 批准号: 8831351
• 负责人: Xiang-Lei Yang
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8831351
• 关键词: Academia; Address; Amino Acyl-tRNA Synthetases; Anemia; Area; Autoimmune Process; Autoimmunity; Bacterial Infections; Basic Science; Biological; Biology; Biotechnology; California; Cell physiology; Cells; Clinic; Clinical; Code; Collaborations; Communicable Diseases; Complex; Development; Diabetes Mellitus; Discipline; Disease; Elements; Fill-It; Goals; Health; Hematological Disease; Human; Immune System Diseases; Industry; Maintenance; Malignant Neoplasms; Metabolic Diseases; Minority; Mitochondrial Diseases; Myositis; Nerve Degeneration; Nucleic Acids; Organism; Participant; Pathologic Processes; Pharmacologic Substance; Physiological; Process; Protein Biosynthesis; Proteins; Regulation; Request for Applications; Research; Research Personnel; Ribosomal Proteins; Ribosomes; Role; Scientist; Series; Structure; System; Time; Transfer RNA; Translation Alteration; Translations; Vascular Diseases; Virus Diseases; Woman; Work; genetic information; human disease; innovation; interest; lectures; meetings; nervous system disorder; novel; posters; public health relevance; symposium; therapeutic development; translation factor

 DESCRIPTION (provided by the applicant): This application requests partial support for a meeting on Translation Machinery in Health & Disease - Protein Synthesis and Beyond as part of the Gordon Research Conference series to be held in Ventura, California, on February 22-27, 2015. This Conference is a new GRC and the first disease-focused, interdisciplinary conference for the broad field of translation. The conference fills a niche that is not addressed by any existing conferences on translation and the translation machinery, which mainly focus on structures of the translation machinery, and its specific functions and regulations in protein synthesis, and not on the "new biology" of this same machinery, the pathological consequence of an altered translation apparatus, or on how translation regulates diverse systems in humans. However, GRC presently has no meeting devoted to translation per se. This circumstance provides an excellent opportunity to develop, under the auspices of the GRC, a new conference to bridge translation to health and disease. The broad and long-term goal of the conference is to deepen our understanding of translation and its connection to health and disease, and to open doors to developing novel treatments and therapies. The conference will cover many disease areas including cancer, neurological diseases, immunological diseases, infectious diseases, hematological and vascular diseases, metabolic diseases, and mitochondrial diseases. The conference will present for the first time a forum for clinicians and basic scientists to discuss their distinct but overlapping interests in these translation-related molecules and diseases. The specific aims of this meeting are to convene 38-46 leading experts that cover critical basic science and clinical topics, with a total of 150 participants, for a five-day meeting. The meeting will be organized into nine sessions including an opening session on the first day featuring 2 keynote lectures, followed by 8 sessions that each focus on a specific disease area. Four additional keynote lectures will start each day for the remaining 4 days of the conference, to provide high-level introductions on topics that are relevant for the day's sessions. The keynote lectures will be given by Drs. Ada Yonath, Paul Schimmel, Nahum Sonenberg and Jonathan Weissman, with two more to be announced. Among them, Dr. Yonath is a Nobel laureate best known for her groundbreaking work on the structure and function of ribosomes; Dr. Schimmel is the most renowned scientist in the tRNA synthetase field, and an entrepreneur who has transferred basic science into therapies through many successful biotechnology companies that he has founded. In addition, four afternoon poster sessions will permit all participants to contribute to the meeting. As with all Gordon Conferences there will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. As the first disease-focused conference for the field of translation, this conference would significantly impact our understanding of many important diseases-such as autoimmune myositis, cancer, neurodegeneration, diabetes, anemia, and viral and bacterial infections-and their treatment.

 描述（由申请人提供）：本申请请求对健康与疾病中的翻译机器 - 蛋白质合成及其他领域的会议提供部分支持，该会议是将于 2 月 22 日至 27 日在加利福尼亚州文图拉举行的戈登研究会议系列的一部分， 2015 年。本次会议是一个新的 GRC，也是翻译广泛领域的首个以疾病为重点的跨学科会议，该会议填补了任何现有翻译和翻译机器会议都没有涉及的空白。主要关注翻译机器的结构，及其在蛋白质合成中的特定功能和调节，而不是同一机器的“新生物学”，翻译装置的病理后果，或翻译如何调节人类的不同系统。 ，GRC 目前还没有专门讨论翻译的会议，这种情况提供了一个绝佳的机会，可以在 GRC 的主持下召开一次新的会议，以将翻译与健康和疾病联系起来。会议的广泛而长期的目标是。加深我们对翻译及其翻译的理解会议将涵盖许多疾病领域，包括癌症、神经系统疾病、免疫疾病、传染病、血液和血管疾病、代谢疾病和线粒体疾病。这是首次为狐狸人和基础科学家讨论他们对这些与翻译相关的分子和疾病的独特但重叠的兴趣的论坛，本次会议的具体目标是召集 38-46 名涵盖关键基础科学和临床主题的领先专家，总共有为期五天的会议将有 150 人参加，会议将分为 9 个会议，其中包括第一天的开幕会议，包括 2 场主题演讲，随后将有 8 场会议，每场会议侧重于一个特定的疾病领域。会议剩余 4 天的每一天，都会就与当天会议相关的主题进行高级介绍。主题演讲将由 Ada Yonath、Paul Schimmel、Nahum Sonenberg 和乔纳森·韦斯曼 (Jonathan Weissman)，其中还有两位即将宣布：尤纳特 (Yonath) 博士是诺贝尔奖获得者，因其在核糖体结构和功能方面的开创性工作而闻名；希梅尔 (Schimmel) 博士是 tRNA 合成酶领域最著名的科学家。企业家通过他创立的许多成功的生物技术公司将基础科学转化为治疗方法。此外，下午四场海报会议将允许所有参与者为会议做出贡献，与所有戈登会议一样，将为年轻研究人员提供大量机会。妇女和少数族裔与该领域的高级领导人互动。 作为翻译领域第一次以疾病为重点的会议，这次会议将极大地影响我们对许多重要疾病（例如自身免疫性肌炎、癌症、神经退行性变、糖尿病、贫血以及病毒和细菌感染）及其治疗的理解。