Improving WNPRC Infrastructure to Support HIV/AIDS Research

改善 WNPRC 基础设施以支持艾滋病毒/艾滋病研究

• 批准号: 8219360
• 负责人: Saverio Vincent Capuano
• 金额: $ 91.55万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8219360
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Animals; Area; Breeding; Ensure; Floor; Funding; HIV; Housing; Individual; Macaca; Macaca mulatta; Mental Health; Pathogenesis; Primates; Protocols documentation; Research; Research Infrastructure; Research Personnel; SIV; Specific Pathogen Frees; United States National Institutes of Health; Well in self; Wisconsin; animal care; germ free condition; improved; programs; vaccine development

DESCRIPTION (provided by applicant): The Wisconsin National Primate Research Center (WNPRC) supports an active HIV/AIDS research program with greater than $8,000,000 in funding from the National Institutes of Health and private entities. WNPRC investigators infect rhesus macaques of Indian ancestry and cynomolgus macaques of Mauritian origin with Simian Immunodeficiency Virus (SIV) to study HIV pathogenesis and vaccine development. Currently, 205 macaques (153 rhesuses, 52 cynomolgus) assigned to 27 individual projects covered by 20 different animal care and use protocols are utilized for HIV/AIDS research at the WNPRC. WNPRC investigators acquire macaques for HIV/AIDS projects from the Center's own Specific Pathogen Free (SPF) breeding colony. This proposal seeks to acquire funding to replace aging stationary caging in the SPF breeding area with contemporary mobile caging. The proposal also seeks funding to augment the existing mobile caging to improve the psychological well being of the SPF colony and the SIV-infected macaques housed at the WNPRC. Finally, this proposal also seeks funding to upgrade the physical infrastructure (e.g., doors, flooring) of the SPF and SIV-infected macaque housing areas of the WNPRC. Successful completion of the aims outlined in this proposal will ensure that WNPRC investigators performing ZHIV/AIDS research are provided with quality animals and that the psychological health of these animals is protected.

描述（由申请人提供）：威斯康星州国家灵长类动物研究中心 (WNPRC) 支持一项积极的艾滋病毒/艾滋病研究计划，由美国国立卫生研究院和私人实体提供超过 8,000,000 美元的资金。 WNPRC 研究人员用猿猴免疫缺陷病毒 (SIV) 感染印度血统的恒河猴和毛里求斯血统的食蟹猴，以研究 HIV 发病机制和疫苗开发。目前，WNPRC 的 205 只猕猴（153 只恒河猴、52 只食蟹猴）被分配到 27 个单独的项目，涵盖 20 种不同的动物护理和使用协议，用于艾滋病毒/艾滋病研究。 WNPRC 调查人员从该中心自己的无特定病原体 (SPF) 繁殖群中获取用于艾滋病毒/艾滋病项目的猕猴。该提案旨在获得资金，用现代移动笼具取代 SPF 繁殖区老化的固定笼具。该提案还寻求资金来增强现有的移动笼舍，以改善 WNPRC 饲养的 SPF 群体和感染 SIV 的猕猴的心理健康。最后，该提案还寻求资金来升级 WNPRC SPF 和 SIV 感染的猕猴居住区的有形基础设施（例如门、地板）。成功完成本提案中概述的目标将确保为进行 ZHIV/AIDS 研究的 WNPRC 研究人员提供优质动物，并保护这些动物的心理健康。