Nonhuman Primate Core

非人类灵长类核心

基本信息

批准号：
10220701
负责人：
Saverio Vincent Capuano
金额：
$ 24.83万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10220701
关键词：
Adherence Americas Amniocentesis Animals Auditory Brainstem Responses Autopsy Behavioral Biomedical Research Body Fluids Brain Cesarean section Clinical Clinical Data Congenital Abnormality Decision Making Dengue Virus Drug or chemical Tissue Distribution Electroretinography Ensure Evaluation Evaluation Studies Fetal health Flavivirus Flavivirus Infections Functional disorder Head Hearing Human Immune response Immunity Infant Care Infection Lead Macaca Macaca mulatta Magnetic Resonance Imaging Maternal Health Maternal-Fetal Transmission Modeling Monitor Neonatal Nurseries Optical Coherence Tomography Partner in relationship Pathology Plasma Play Pregnancy Primates Principal Investigator Procedures Program Research Project Grants Protocols documentation Public Health Recommendation Regulation Research Research Personnel Role Sampling Scientist Sensory Serotyping Services Techniques Testing Time Tissues Training Transportation Ultrasonography Vaccination Veterinary Pathology Wisconsin ZIKV infection Zika Virus animal care care coordination congenital infection environmental enrichment for laboratory animals experimental study fetal germ free condition histopathological examination meetings neonatal care neonatal outcome neurobehavioral neurodevelopment nonhuman primate pregnant programs

项目摘要

NHP Core - Project Summary/Abstract The emergence of Zika virus (ZIKV) in the Americas and its association with fetal demise and birth defects represents a significant public health challenge. To date, very little is known about how maternal-fetal transmission occurs and what factors influence fetal pathology during congenital infection. Thus, understanding the pathophysiology of ZIKV infection during pregnancy is critical. The use of a nonhuman primate (NHP) model for ZIKV infection during pregnancy will allow finescale and comprehensive examination of the pathology and duration of infection, the influence of pre-existing dengue virus immunity on infection, and the immune response to infection; important studies that are not possible in humans. The NHP model is additionally ideal for these studies due to the relative similarity of macaque pregnancies to human pregnancies. The Non-Human Primate (NHP) Core is an integral component of the Program Project and provides direct support to all three Projects. The NHP Core will provide healthy animals, coordinate and implement all aspects of the proposed NHP experiments, establish and verify pregnancies and monitor maternal and fetal health, perform necropsies and detailed histopathological examinations, assess neonatal outcomes, and provide compliance oversight and biosafety training for all three Projects.

NHP 核心 - 项目摘要/摘要寨卡病毒 (ZIKV) 在美洲的出现及其与胎儿死亡和出生的关系缺陷是一项重大的公共卫生挑战。迄今为止，人们对母婴传播如何发生以及先天性感染期间哪些因素影响胎儿病理学知之甚少。因此，了解妊娠期间 ZIKV 感染的病理生理学至关重要。使用一个用于妊娠期间 ZIKV 感染的非人灵长类动物 (NHP) 模型将能够对病理学和感染持续时间以及先前存在的登革热病毒的影响进行精细和全面的检查对感染的免疫力，以及对感染的免疫反应；不可能进行的重要研究人类。由于猕猴的相对相似性，NHP 模型对于这些研究来说也是理想的选择怀孕到人类怀孕。非人类灵长类动物 (NHP) 核心是计划项目并向所有三个项目提供直接支持。 NHP 核心将提供健康动物，协调和实施拟议的 NHP 实验的各个方面，建立和验证怀孕并监测母婴健康，进行尸检和详细的组织病理学检查检查、评估新生儿结局，并提供合规监督和生物安全培训所有三个项目。