Evaluation of Sensory Integration Treatment in ASD

自闭症谱系障碍感觉统合治疗的评估

• 批准号: 7933766
• 负责人: Stephen Mark Camarata
• 金额: $ 34.53万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933766
• 关键词: Address; Aftercare; Auditory; Behavioral; Child; Classification; Clinical; Clinical Trials Design; Communication; Control Groups; Cream; Development; Diagnostic; Electroencephalography; Evaluation; Feasibility Studies; Growth; Hand; Heterogeneity; Image; Intervention; Language; Manuals; Massage; Measures; Neurologic; Occupational Therapist; Participant; Performance; Phase; Preparation; Prevalence; Principal Investigator; Procedures; Process; Psychophysiology; Randomized; Randomized Clinical Trials; Request for Applications; Research Design; Sampling; Sensory; Sensory Process; Silicon Dioxide; Social Interaction; Speech; Techniques; Training; Treatment Protocols; Visual; Weight; autism spectrum disorder; base; behavior measurement; communication behavior; desensitization; design; evidence base; experience; group intervention; improved; multisensory; neuroimaging; post intervention; pressure; public health relevance; research study; response; sensory integration; skills; social skills; treatment effect

DESCRIPTION (provided by applicant): As noted in the request for applications, a key aspect of heterogeneity in autism spectrum disorders (ASD) is a relatively high number of clinical interventions that are commonly provided but have limited or even no objective evidence to support implementation. Sensory integration deficit (SID) is a controversial but widely used diagnostic classification in ASD and sensory integration based treatment (SIT) is now routinely provided to children with autism spectrum disorder, but has an extremely limited evidence base. The purpose of this R34 proposal will be to complete developmental analyses in preparation for a relatively large randomized comparison trial examining the effects of commonly implemented sensory integration treatment techniques on communication development in ASD. A total of 40 participants with ASD will be randomly assigned to either a sensory integration (SIT) or pivotal response training (PRT) comparison condition. In addition, pre-and post intervention behavioral and neuro-imaging measures of multi-sensory processing will be gathered and analyzed to determine whether changes in multi-sensory processing are associated with SIT intervention. Two years of support are requested. PUBLIC HEALTH RELEVANCE: Children with autism spectrum disorder (ASD) display severe disruptions in communication and social interaction. There are many unproven treatments thought to improve the skills that are widely implemented. The purpose of this project will be to evaluate whether sensory integration treatment is associated with improvements in communication and social skills in children with ASD.

描述（由申请人提供）：如申请请求中所述，自闭症谱系障碍异质性（ASD）的关键方面是通常提供的临床干预措施数量相对较大，但提供了有限的临床干预措施，但没有客观的证据支持实施。感官整合不足（SID）是一种有争议的但广泛使用的ASD和基于感觉整合治疗（SIT）的诊断分类（SIT），现在通常向患有自闭症谱系障碍的儿童提供，但证据基础极为有限。该R34提案的目的是完成开发分析，以准备一项相对较大的随机比较试验，以检查常见实施的感觉整合处理技术对ASD通信发展的影响。共有40名患有ASD的参与者将随机分配给感觉积分（SIT）或关键响应训练（PRT）比较条件。此外，将收集和分析在干预前后的行为和神经成像措施，以确定多感官处理的变化是否与SIT干预有关。请求两年的支持。 公共卫生相关性：自闭症谱系障碍（ASD）的儿童在沟通和社交互动中表现出严重的破坏。有许多未经证实的治疗方法被认为可以提高广泛实施的技能。该项目的目的是评估感官整合处理是否与ASD儿童的沟通和社交技能的改善有关。

项目成果

Behavioral, perceptual, and neural alterations in sensory and multisensory function in autism spectrum disorder.

• DOI: 10.1016/j.pneurobio.2015.09.007
• 发表时间: 2015-11
• 期刊: Progress in neurobiology
• 影响因子: 6.7
• 作者: Baum SH;Stevenson RA;Wallace MT
• 通讯作者: Wallace MT

Multisensory speech perception in children with autism spectrum disorders.

• DOI: 10.1007/s10803-013-1836-5
• 发表时间: 2013-12
• 期刊: Journal of autism and developmental disorders
• 影响因子: 3.9
• 作者: Woynaroski TG;Kwakye LD;Foss-Feig JH;Stevenson RA;Stone WL;Wallace MT
• 通讯作者: Wallace MT

The construct of the multisensory temporal binding window and its dysregulation in developmental disabilities.

• DOI: 10.1016/j.neuropsychologia.2014.08.005
• 发表时间: 2014-11
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Wallace, Mark T.;Stevenson, Ryan A.
• 通讯作者: Stevenson, Ryan A.

Evidence for diminished multisensory integration in autism spectrum disorders.

自闭症谱系障碍中多感觉整合减弱的证据。

• DOI: 10.1007/s10803-014-2179-6
• 发表时间: 2014
• 期刊: Journal of autism and developmental disorders
• 影响因子: 3.9
• 作者: Stevenson,RyanA;Siemann,JustinK;Woynaroski,TiffanyG;Schneider,BrittanyC;Eberly,HaleyE;Camarata,StephenM;Wallace,MarkT
• 通讯作者: Wallace,MarkT

Deficits in audiovisual speech perception in normal aging emerge at the level of whole-word recognition.

正常衰老过程中视听言语感知的缺陷出现在整个单词识别的水平上。

• DOI: 10.1016/j.neurobiolaging.2014.08.003
• 发表时间: 2015
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Stevenson,RyanA;Nelms,CaitlinE;Baum,SarahH;Zurkovsky,Lilia;Barense,MorganD;Newhouse,PaulA;Wallace,MarkT
• 通讯作者: Wallace,MarkT