Image-Guided Cochlear Implant Programming: Pediatric Speech, Language, and Literacy

图像引导人工耳蜗编程：儿科言语、语言和读写能力

• 批准号: 9765569
• 负责人: Stephen Mark Camarata
• 金额: $ 46.28万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9765569
• 关键词: 12 year old; Acoustics; Adult; Articulation; Auditory; Auditory system; Child; Childhood; Clinical; Clinical Trials Design; Cochlear Implants; Complex; Control Groups; Development; Distal; Double-Blind Method; Early Intervention; Electric Stimulation; Electrodes; Enrollment; Generations; Goals; Growth; Interdisciplinary Study; Intervention; Language; Language Disorders; Literature; Location; Measures; Mediating; Mediator of activation protein; Modeling; Monitor; Noise; Outcome; Participant; Patients; Procedures; Production; Psychophysics; Randomized; Randomized Clinical Trials; Randomized Controlled Clinical Trials; Reading; Regression Analysis; Research; Research Activity; Research Design; Resolution; Sampling; Short-Term Memory; Signal Transduction; Speech; Speech Disorders; Standardization; Technology; Testing; Time; Waiting Lists; aged; auditory deprivation; auditory processing; hearing impairment; image guided; implantation; improved; improved outcome; literacy; normal hearing; peer; phonological awareness; phonology; reading ability; reading comprehension; reading difficulties; signal processing; skills; speech recognition; temporal measurement

PROJECT SUMMARY Although the recent literature has indicated that children receiving cochlear implants (CIs) often have dramatically improved speech and language ability relative to previous generations of children with hearing loss, many pediatric CI recipients display persistent speech and language disorders despite early implantation and associated speech/language intervention. There is a striking paucity and ongoing need for studies that systematically examine the relationship between intracochlear electrode location, audiological profile, and subsequent phonological awareness, speech, language, and literacy in pediatric CI recipients. This project provides a unique opportunity to examine whether individualized, image-guided CI programming (IGCIP) significantly improves outcomes in pediatric CI patients. The proposed research activities will examine the impact of personalized IGCIP in pediatric CI recipients on measures of basic auditory function (spectral, temporal, and spectrotemporal resolution), word and non-word recognition, speech production, language, phonological awareness, and reading comprehension using a double blind, waitlist control randomized clinical trial (RCT) design. A total sample of 72 children with CIs aged six to twelve years old will be enrolled in the project: half (n = 36) will be randomized to an immediate IGCIP condition and half to a waitlist control condition. The waitlisted participants (n = 36) will undergo IGCIP after 12 months of monitoring and then followed for an additional 12 months after intervention (total time in the study for both groups: 24 months). Those immediately provided with IGCIP will also be followed for a total of 24 months. All participants will undergo extensive audiological assessment as well as tests of phonological awareness, speech, language, and literacy at baseline as well as at regular intervals: 2, 6, 12, 14, 18, and 24 months. We will use predictor analyses to determine the impact of immediate and deferred IGCIP on subsequent auditory, speech, language, and literacy outcomes.

项目摘要 尽管最近的文献表明接受人工耳蜗（CI）的儿童经常有 相对于前几代儿童听力的语音和语言能力极大地提高了 损失，许多儿科CI接受者尽管早期植入表现出持续的语音和语言障碍 以及相关的语音/语言干预。有惊人的缺乏和持续的研究需求 系统地检查当扫描内电极位置，听力学轮廓和 随后的儿科CI接受者中的语音意识，语音，语言和素养。这个项目 提供了一个独特的机会来检查个性化的，图像引导的CI编程（IGCIP）是否 小儿CI患者的预后显着改善。拟议的研究活动将研究 个性化IGCIP对小儿CI接受者的影响对基本听觉功能的度量（光谱， 时间和光谱分辨率），单词和非单词识别，语音产生，语言， 语音意识和使用双盲候补控制随机临床的阅读理解 试验（RCT）设计。总共有72名6至12岁儿童的样本将入学 项目：一半（n = 36）将被随机分为立即的IGCIP条件，一半为候补列表的控制条件。 候补名单参与者（n = 36）将在监视12个月后接受IGCIP，然后遵循 干预后的12个月（两组研究中的总时间：24个月）。那些立即 还将遵循IGCIP提供的24个月。所有参与者都会经历广泛的 听力学评估以及语音意识，语音，语言和扫盲的测试 基线以及定期的间隔：2、6、12、14、18和24个月。我们将使用预测分析进行 确定直接和递延IGCIP对后续听觉，语音，语言和扫盲的影响 结果。