Predictors of Speech Ability in Children with Down Syndrome

唐氏综合症儿童言语能力的预测因素

• 批准号: 10584659
• 负责人: Stephen Mark Camarata
• 金额: $ 15.15万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10584659
• 关键词: Academy; Accent; Accounting; Acoustics; Adolescence; Age; Articulation; Articulators; Biological Assay; Birth; Child; Clinical; Clinical Trials; Cognitive; Communication; Comprehension; Data; Development; Down Syndrome; Frequencies; Future; Goals; Growth; Human; Individual; Intervention; Intervention Studies; Investigational Therapies; Language; Language Disorders; Learning; Linguistics; Literature; Longitudinal Studies; Measures; Medicine; Modeling; Motor; Motor Skills; Outcome; Paper; Participant; Periodicity; Persons; Process; Production; Reading; Reporting; Research; Research Project Grants; School-Age Population; Series; Speech; Speech Development; Speech Disorders; Speech Intelligibility; Structure; Students; Testing; Translational Research; Variant; Vocabulary; Work; base; cognitive ability; design; experience; improved; insight; lexical; oral motor; phonology; post intervention; prospective; reading ability; skills; speech accuracy; therapy design

ABSTRACT Speech is a critical aspect of the human experience and usually develops in a “seemingly automatic process that continues from birth through adolescence (p.1, NAM, 2016)” and underlies many related abilities (e.g., language and reading, see National Academy of Medicine Report on Speech and Language Disorders, 2016). Many individuals with Down Syndrome (Trisomy 21, DS) struggle to communicate and participate more fully in human communication and educational learning experiences because their speech is difficult to understand. The purpose of the proposed project is to measure speech-articulation accuracy and speech intelligibility, and their proposed primary predictors at study entry in 20 children with DS age 7;0 to 12;11. A validated treatment, speech recast intervention (see Yoder, Camarata & Woynaroski, 2016) will be used to drive growth in speech intelligibility as a means of evaluating changes in potential sequelae of change. This integrated study will include measures of speech- articulation accuracy, speech-prosody, general cognitive ability, receptive vocabulary skills, and clinical assay of oral-motor ability as potential predictors of speech intelligibility growth in DS. We will also be measuring suprasegmental and rhythmic factors associated with growth. The results of this study will provide important information on factors that contribute to intelligible speech in DS and subsequently provide the basis for refining and future intervention investigations of treatment for speech deficits in children with DS.

抽象的 言语是人类经验的关键方面，通常在“看似 从出生到青少年（第1页，NAM，2016年）的自动过程”和 基础许多相关能力（例如，语言和阅读，请参阅国家医学学院 言语和语言障碍的报告，2016年）。许多患有唐氏综合症的人 （Trisome 21，ds）努力沟通和参与人类交流 和教育学习经历，因为他们的言语很难理解。这 拟议项目的目的是衡量语音推动准确性和语音 清晰度及其在20名DS年龄7岁儿童的研究进入时提议的主要预测因素； 0 到12; 11。经过验证的治疗，语音重铸干预（请参阅Yoder，Camarata＆ Woynaroski，2016年）将用于推动语音清晰度的增长作为评估的手段 潜在变化后遗症的变化。这项综合研究将包括语音衡量 - 阐明精度，语音攻击，一般认知能力，接受词汇技巧和 口服运动能力作为DS语音清晰度增长的潜在预测指标的临床评估。 我们还将衡量与生长相关的上段和节奏因素。这 这项研究的结果将提供有关导致可理解的因素的重要信息 DS中的语音，随后为精炼和将来的干预提供了基础 对DS儿童的语音治疗的调查。