TRANSGENIC MOUSE FACILITY (SHARED RESOURCE)

转基因小鼠设施（共享资源）

基本信息

批准号：
7944541
负责人：
Arthur D Lander
金额：
$ 5.07万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-06 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944541
关键词：
Age Alleles Aneuploidy Animal Model Antibiotic Resistance Applications Grants Back Base Pairing Breeding Cancer Biology Cancer Center Support Grant Cancer Model Cancer Research Project Cell Culture Techniques Cell Line Cell Lineage Cells Characteristics Chimera organism Chromosomes Client Code Complex Consultations Cryopreservation DNA Derivation procedure Development Disease ES Cell Line Electroporation Embryo Embryo Transfer Engineering Equipment Event Fees Female Fertilization in Vitro Fostering Freezing Funding Gene Expression Gene Targeting Genes Genome Genomics Genotype Goals Grant Green Fluorescent Proteins Growth Hand Harvest Head Health Status Hour In Vitro Individual Injection of therapeutic agent Institution Intention Karyotype Karyotype determination procedure Knock-in Mouse Knock-out Knowledge LacZ Genes Letters Life Link Location Malignant Neoplasms Measures Methods Microinjections Mission Molecular Mothers Mouse Strains Mus Mutation Nature Non-Commercial Sources Oocytes Outcome Partner in relationship Pattern Phenotype Plasmids Positioning Attribute Process Proteins Reporter Genes Research Research Personnel Resistance Resource Sharing Resources Role Services Site Southern Blotting Staging Stretching Tail Technology Temperature Time Tissues Transgenes Transgenic Mice Transgenic Mouse Facility University of California Irvine Cancer Center Work base blastocyst cost embryonic stem cell experience homologous recombination human disease in vivo interest mature animal member offspring pathogen pluripotency preimplantation promoter recombinase transmission process

项目摘要

The mission of the Transgenic Mouse Facility at UC-lrvine is to facilitate the use of genetically modified mice in hypothesis-driven research by providing services for making, breeding, genotyping, importing, and preserving mouse strains. Our primary goal is to offer these services at the lowest possible cost while producing yields and outcomes that compare favorably with similar facilities at other academic institutions. We are in a strong position to assist in the development of in vivo mammalian models of cancer and to provide strains of mice that are critical to understanding the molecular basis of cancer.

UC-Lrvine在UC-LRVINE上的转基因小鼠设施的任务是促进转基因小鼠的使用在假设驱动的研究中，通过为制造，繁殖，基因分型，进口和保留小鼠菌株。我们的主要目标是以最低的成本提供这些服务与其他学术机构的类似设施相比，产生产量和成果。我们处于强大的位置，可以协助开发体内哺乳动物的癌症模型和提供对了解癌症分子基础至关重要的小鼠菌株。