Zebrafish International Resource Center

斑马鱼国际资源中心

• 批准号: 7920734
• 负责人: Monte Westerfield
• 金额: $ 78.69万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2013-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7920734
• 关键词: Zebrafish; International; Resource; Center

Zebrafish has emerged as a premiere organism to study vertebrate development and genetics. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials, 2) to provide consultation and pathology services, and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.

斑马鱼已成为研究脊椎动物发育和遗传学的首要生物。强大的 技术可以有效生成和恢复影响调节基因的斑马鱼突变 发育模式、器官发生、生理和行为。最近的进展使得很容易 使用反义寡核苷酸研究转基因斑马鱼的基因功能。很多的功能 这些基因的一部分在脊椎动物群体中是保守的。因此，斑马鱼突变的分析提供了 深入了解包括人类在内的其他脊椎动物的基因功能。 斑马鱼国际资源中心已成立，作为一个提供动物、 为研究界提供材料和服务。该提案寻求持续资助 1) 提供 斑马鱼遗传资源和研究材料的集中存储库，2) 提供咨询和 病理学服务，3) 开发改进的斑马鱼饲养方法。这些材料、服务 信息将广泛提供给研究界。