Reward and Control Processing in Cigarette Smoking Usins fMRI

使用功能磁共振成像研究吸烟的奖励和控制处理

• 批准号: 7929463
• 负责人: CHRISTINA N LESSOV-SCHLAGGAR
• 金额: $ 14.84万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7929463
• 关键词: Adolescence; Alcohols; Behavioral; Behavioral Genetics; Brain; Caucasoid Race; Childhood; Cigarette; Cognitive; Complement; Data; Data Analyses; Data Collection; Development; Dizygotic Twins; Drug usage; Environment; Epidemiology; Equation; Ethnic Origin; Etiology; Exposure to; Family; Female; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Genetic Risk; Goals; Hand; Illicit Drugs; Individual; Institution; Investigation; Knowledge; Laboratory Study; Learning; Literature; Logistic Regressions; Malignant neoplasm of lung; Maps; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Morbidity - disease rate; Neurobiology; Performance; Pilot Projects; Positioning Attribute; Preventive Intervention; Process; Recording of previous events; Research; Research Design; Research Training; Rewards; Risk; Risk Factors; Sampling; Series; Smoke; Smoker; Smoking; Socioeconomic Status; Source; Subjects Selections; System; Testing; Time; Tobacco Dependence; Tobacco use; Training; Training Programs; Twin Multiple Birth; Variant; Work; addiction; base; career; cigarette smoking; cognitive neuroscience; design; early onset; emerging adult; externalizing behavior; family genetics; genetic epidemiology; improved; indexing; mortality; neuroimaging; programs; prospective; psychogenetics; public health relevance; relating to nervous system; reward circuitry; skills; smoking cessation; young adult

DESCRIPTION (provided by applicant): The candidate, Dr. Christina Lessov-Schlaggar, seeks support for 5 years through this Mentored Research Scientist Development Award (K01) in order to (1) obtain training in functional neuroimaging to complement her training in psychiatric genetics of tobacco use etiology; (2) gain understanding of developmental cognitive neuroscience to enhance knowledge and guide current and future investigation of tobacco use etiology; and (3) improve statistical skills for longitudinal data analysis. This proposal will prepare the applicant to establish an independent research program to understand neural and cognitive mechanisms of addiction development using genetic and neuroimaging approaches. This goal will be achieved through (i) secondary data analysis of developmental smoking trajectories and their relationship to tobacco dependence in a genetically informative sample of twins, and (ii) functional neuroimaging pilot data collection in a subset of the same twin sample to examine brain activation differences in addiction-related regions between regular and non-regular smokers. The functional neuroimaging pilot study will employ a co-twin control design which allows investigation of the effects of regular smoking on neural processing, unconfounded by genetic and family background factors. Since smoking trajectory and neuroimaging data will be available from the same individuals, brain activation differences can be mapped onto differences in smoking trajectories, which will serve as one reference point for subject selection and study design for future R01 applications. This proposal describes a comprehensive and focused training program that includes formal coursework, supervised self-directed learning and hands-on training in one of the nation's leading academic institutions and under the guidance of leaders in the fields of functional neuroimaging (Dr. Deanna Barch, mentor; Dr. Steven Petersen, co-mentor), genetics of tobacco use etiology (Dr. Pamela Madden, co-mentor), and behavioral genetics (Dr. Andrew Heath, consultant). PUBLIC HEALTH RELEVANCE: Cigarette smoking is the single, most preventable cause of lung cancer and is a significant source of morbidity and mortality worldwide. Improved understanding of brain and cognitive mechanisms of tobacco dependence and its development will contribute to better, potentially individually-tailored, prevention, intervention, and treatment approaches.

描述（由申请人提供）：候选人克里斯蒂娜·莱索夫·斯拉格加（Christina Lessov-Schlaggar）博士通过这项受过指导的研究科学家发展奖（K01）寻求5年的支持，以（1）获得功能性神经影像学培训，以补充她在烟草遗传学的精神遗传学培训中的培训； （2）了解发展性认知神经科学，以增强知识并指导对烟草使用病因的当前和未来研究； （3）提高纵向数据分析的统计技能。该建议将使申请人准备建立独立的研究计划，以使用遗传和神经影像学方法来了解成瘾发展的神经和认知机制。将通过（i）（i）对双胞胎的遗传信息样本中的发育性吸烟轨迹的二级数据分析及其与烟草依赖性的关系，以及（ii）在同一双胞胎样本的子集中收集功能性神经影像图，以检查常规和非注射量身定向吸烟者之间的成瘾相关区域中脑部激活差异。功能性神经影像学试验研究将采用联合双重控制设计，该设计允许调查常规吸烟对神经加工的影响，这与遗传和家庭背景因素无关。由于吸烟轨迹和神经影像学数据将从相同的个体中获得，因此可以将大脑激活差异映射到吸烟轨迹的差异上，这将是对未来R01应用的主题选择和研究设计的一个参考点。 This proposal describes a comprehensive and focused training program that includes formal coursework, supervised self-directed learning and hands-on training in one of the nation's leading academic institutions and under the guidance of leaders in the fields of functional neuroimaging (Dr. Deanna Barch, mentor; Dr. Steven Petersen, co-mentor), genetics of tobacco use etiology (Dr. Pamela Madden, co-mentor), and behavioral遗传学（Andrew Heath博士，顾问）。 公共卫生相关性：吸烟是肺癌的单一，最可预防的原因，是全球发病率和死亡率的重要来源。对烟草依赖性及其发育的大脑和认知机制的了解得以提高，将有助于更好，潜在的个人预防，预防，干预和治疗方法。