Reward and Control Processing in Cigarette Smoking Usins fMRI

使用功能磁共振成像研究吸烟的奖励和控制处理

• 批准号: 8128691
• 负责人: CHRISTINA N LESSOV-SCHLAGGAR
• 金额: $ 15.29万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128691
• 关键词: Adolescence; Alcohols; Behavioral; Behavioral Genetics; Brain; Caucasoid Race; Childhood; Cigarette; Cognitive; Complement; Data; Data Analyses; Data Collection; Development; Dizygotic Twins; Drug usage; Environment; Epidemiology; Equation; Ethnic Origin; Etiology; Exposure to; Family; Female; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Genetic Risk; Goals; Illicit Drugs; Individual; Institution; Investigation; Knowledge; Laboratory Study; Learning; Literature; Logistic Regressions; Malignant neoplasm of lung; Maps; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Morbidity - disease rate; Neurobiology; Performance; Pilot Projects; Positioning Attribute; Preventive Intervention; Process; Recording of previous events; Research; Research Design; Research Training; Rewards; Risk; Risk Factors; Sampling; Series; Smoke; Smoker; Smoking; Socioeconomic Status; Source; Study Subject; Subjects Selections; System; Testing; Time; Tobacco Dependence; Tobacco use; Training; Training Programs; Twin Multiple Birth; Variant; Work; addiction; base; career; cigarette smoking; cognitive neuroscience; design; early onset; emerging adult; externalizing behavior; family genetics; genetic epidemiology; improved; indexing; mortality; neuroimaging; programs; prospective; psychogenetics; public health relevance; relating to nervous system; reward circuitry; skills; smoking cessation; young adult

DESCRIPTION (provided by applicant): The candidate, Dr. Christina Lessov-Schlaggar, seeks support for 5 years through this Mentored Research Scientist Development Award (K01) in order to (1) obtain training in functional neuroimaging to complement her training in psychiatric genetics of tobacco use etiology; (2) gain understanding of developmental cognitive neuroscience to enhance knowledge and guide current and future investigation of tobacco use etiology; and (3) improve statistical skills for longitudinal data analysis. This proposal will prepare the applicant to establish an independent research program to understand neural and cognitive mechanisms of addiction development using genetic and neuroimaging approaches. This goal will be achieved through (i) secondary data analysis of developmental smoking trajectories and their relationship to tobacco dependence in a genetically informative sample of twins, and (ii) functional neuroimaging pilot data collection in a subset of the same twin sample to examine brain activation differences in addiction-related regions between regular and non-regular smokers. The functional neuroimaging pilot study will employ a co-twin control design which allows investigation of the effects of regular smoking on neural processing, unconfounded by genetic and family background factors. Since smoking trajectory and neuroimaging data will be available from the same individuals, brain activation differences can be mapped onto differences in smoking trajectories, which will serve as one reference point for subject selection and study design for future R01 applications. This proposal describes a comprehensive and focused training program that includes formal coursework, supervised self-directed learning and hands-on training in one of the nation's leading academic institutions and under the guidance of leaders in the fields of functional neuroimaging (Dr. Deanna Barch, mentor; Dr. Steven Petersen, co-mentor), genetics of tobacco use etiology (Dr. Pamela Madden, co-mentor), and behavioral genetics (Dr. Andrew Heath, consultant). PUBLIC HEALTH RELEVANCE: Cigarette smoking is the single, most preventable cause of lung cancer and is a significant source of morbidity and mortality worldwide. Improved understanding of brain and cognitive mechanisms of tobacco dependence and its development will contribute to better, potentially individually-tailored, prevention, intervention, and treatment approaches.

描述（由申请人提供）：候选人 Christina Lessov-Schlaggar 博士通过导师研究科学家发展奖 (K01) 寻求 5 年的支持，以便 (1) 获得功能神经影像方面的培训，以补充她在精神科遗传学方面的培训烟草使用病因学； (2) 了解发育认知神经科学，以增强知识并指导当前和未来的烟草使用病因学研究； (3) 提高纵向数据分析的统计技能。该提案将使申请人准备好建立一个独立的研究计划，以利用遗传和神经影像学方法了解成瘾发展的神经和认知机制。这一目标将通过以下方式实现：（i）对双胞胎遗传信息样本中的发育吸烟轨迹及其与烟草依赖的关系进行二次数据分析，以及（ii）在同一双胞胎样本的子集中收集功能性神经影像试点数据以检查大脑经常吸烟者和不经常吸烟者之间成瘾相关区域的激活差异。功能性神经影像试点研究将采用双双胞胎控制设计，研究经常吸烟对神经处理的影响，不受遗传和家庭背景因素的影响。由于吸烟轨迹和神经影像数据将来自同一个人，因此大脑激活差异可以映射到吸烟轨迹的差异，这将作为未来 R01 应用的受试者选择和研究设计的一个参考点。该提案描述了一个全面而有针对性的培训计划，包括在美国领先的学术机构之一并在功能神经影像领域的领导者（Deanna Barch 博士，导师；Steven Petersen 博士，共同导师）、烟草使用病因遗传学（Pamela Madden 博士，共同导师）和行为遗传学（Andrew Heath 博士，顾问）。 公共卫生相关性：吸烟是导致肺癌的唯一且最可预防的原因，也是全世界发病率和死亡率的重要来源。提高对烟草依赖及其发展的大脑和认知机制的了解，将有助于制定更好的、可能个性化的预防、干预和治疗方法。