Modernization and Expansion of the Citigroup Biomedical Imaging Center at Weill Cornell Medical College

威尔康奈尔医学院花旗集团生物医学成像中心的现代化和扩建

• 批准号: 10795469
• 负责人: DOUGLAS J BALLON
• 金额: $ 800万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-14 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795469
• 关键词: Animal Disease Models; Carbon; Cyclotrons; Dedications; Development; Diagnosis; Discipline; Environment; Funding; Future; General Anesthesia; Genetic Medicine; Grant; Human; Image; Imaging Techniques; Infrastructure; Institution; International; Interruption; Label; Lead; Magnetic Resonance Imaging; Modernization; NMR Spectroscopy; Neurodegenerative Disorders; New York City; Nuclear Magnetic Resonance; Oncology; Orthopedics; Positron-Emission Tomography; Principal Investigator; Production; Psychiatry; Radiochemistry; Radioisotopes; Radiopharmaceuticals; Research Personnel; Research Project Grants; Research Subjects; Research Support; Resources; Safety; Spectrum Analysis; Therapeutic Intervention; Time; Tracer; Ultrasonography; United States National Institutes of Health; X-Ray Computed Tomography; biomedical imaging; cost; human disease; human subject; image guided; imaging facilities; imaging study; invention; medical schools; neurosurgery; optical imaging; preclinical study; radiotracer; recruit; single photon emission computed tomography; structural biology

ABSTRACT The proposed project involves major modernization and focused construction at the rapidly growing Citigroup Biomedical Imaging Center (CBIC) of Weill Cornell Medical College in Manhattan, New York City. The CBIC is a comprehensive imaging research resource dedicated to the development of new biomedical imaging techniques in support of a wide range of investigators engaged in the diagnosis and treatment of human disease. Since its inception in 2001, the CBIC has routinely served over 100 Principal Investigators from more than 10 institutions in any given year (148 groups from 14 institutions in 2022, our largest usage ever). The research supported by the CBIC has both a national and international impact due to the many investigators who are leaders in their respective disciplines, lead large multi-institutional research projects, invent new imaging techniques, and recruit human subjects worldwide. The range of projects supported with CBIC imaging resources is extremely broad, and includes studies in neurosurgery, psychiatry, neurodegenerative disease, oncology, orthopedics, genetic medicine, and structural biology. The annual total costs of NIH grants that are supported typically exceeds $50 million. In 2022, a record 172 NIH funded projects were supported by CBIC with total costs of over $118 million. The Center offers ten major imaging and spectroscopy platforms for both human and pre-clinical studies, including magnetic resonance imaging (MRI) and spectroscopy, positron emission tomography (PET), computed tomography (CT), single photon emission computed tomography, ultrasound, and optical imaging. In addition, complete cyclotron and radiochemistry facilities are available. We have now surpassed the 20-year mark since the Center was established, and we have an urgent need for major modernization and construction of infrastructure in order to continue to provide a safe, state-of-the-art environment for imaging studies involving both human subjects and animal models of disease for our rapidly increasing pool of investigators. In order to meet our present and future needs, we propose the following five project components: 1) Construction of a new positron emission tomography/computed tomography (PET/CT) suite, facilitating whole-body PET for the first time, 2) construction of a new modern high field nuclear magnetic resonance (NMR) spectroscopy suite for our three high field NMR spectrometers, 3) renovation of our radiopharmaceutical production suite, allowing us to separate radiochemistry needed for production of our high demand carbon-11 labeled radiotracers from that of tracers produced with other radioisotopes, 4) installation of tank manifolds and supply lines to enable general anesthesia capability, allowing us to accept a wider range of research subjects than is currently possible, 5) addition of electrical infrastructure to two key scanners (one MRI and one PET) to ensure that transient power interruptions are minimized, thereby significantly increasing the safety of ongoing and anticipated image- guided therapeutic interventions.

抽象的 拟建项目涉及重大​​现代化建设，重点建设在快速发展的地区 纽约曼哈顿威尔康奈尔医学院花旗集团生物医学影像中心 (CBIC) 城市。 CBIC 是一个综合性影像研究资源，致力于开发新的 生物医学成像技术支持从事诊断和治疗的广泛研究人员 治疗人类疾病。自 2001 年成立以来，CBIC 已定期为 100 多名委托人提供服务 任意一年来自 10 多个机构的研究人员（2022 年来自 14 个机构的 148 个小组） 有史以来最大的使用量）。 CBIC 支持的研究具有国内和国际影响力，因为 许多研究人员都是各自学科的领导者，领导大型多机构研究 项目，发明新的成像技术，并在世界各地招募人类受试者。项目范围 CBIC 影像资源支持的范围极其广泛，包括神经外科、精神病学、 神经退行性疾病、肿瘤学、骨科、遗传医学和结构生物学。年度总计 NIH 资助的成本通常超过 5000 万美元。 2022 年，NIH 资助的项目达到创纪录的 172 个 获得 CBIC 的支持，总成本超过 1.18 亿美元。该中心提供十大影像和 用于人类和临床前研究的光谱平台，包括磁共振成像 (MRI) 和光谱学、正电子发射断层扫描 (PET)、计算机断层扫描 (CT)、单光子发射 计算机断层扫描、超声和光学成像。此外，完整的回旋加速器和放射化学 设施齐备。中心成立至今已经走过了20年的历程，我们 迫切需要进行重大现代化建设和基础设施建设，以继续提供 为涉及人类受试者和动物模型的成像研究提供一个安全、最先进的环境 我们迅速增加的研究人员队伍中的疾病。为了满足我们现在和未来的需求，我们 提出以下五个项目组成部分： 1）建设新的正电子发射装置 断层扫描/计算机断层扫描 (PET/CT) 套件，首次促进全身 PET 扫描，2) 为我们的三个项目建造一个新的现代高场核磁共振 (NMR) 光谱套件 高场核磁共振波谱仪，3) 改造我们的放射性药物生产套件，使我们能够 将生产我们的高要求碳 11 标记放射性示踪剂所需的放射化学与 用其他放射性同位素产生的示踪剂，4) 安装储罐歧管和供应管线，以实现一般 麻醉能力，使我们能够接受比目前更广泛的研究课题，5) 为两台关键扫描仪（一台 MRI 和一台 PET）添加电气基础设施，以确保瞬态电源 中断被最小化，从而显着提高正在进行和预期图像的安全性 指导性治疗干预。