Major Cyclotron Upgrades and Refurbishment

主要回旋加速器升级和翻新

• 批准号: 10177451
• 负责人: DOUGLAS J BALLON
• 金额: $ 156.22万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177451
• 关键词: 20 year old; Area; Basic Science; Biomedical Research; Clinical Research; Computers; Core Facility; Cost Sharing; Costs and Benefits; Cyclotrons; Disease; Ensure; Failure; Funding; Genetic Diseases; Goals; Grant; Image; Inflammatory; Infrastructure; Institution; Investments; Malignant Neoplasms; Medicine; Memorial Sloan-Kettering Cancer Center; Mental disorders; Mission; Nerve Degeneration; New York; Positron-Emission Tomography; Radioisotopes; Research; Research Personnel; Research Project Grants; Research Support; Services; Technical Expertise; Technology; Translational Research; United States National Institutes of Health; Universities; Vascular Diseases; bioimaging; cost; end of life; innovation; instrumentation; ion source; medical schools; programs; radio frequency; radiotracer; research and development; tool

PROJECT SUMMARY Weill Medical College of Cornell University (Weill Cornell Medicine, WCM) and Memorial Sloan- Kettering Cancer Center (MSK) request High-End Instrumentation Grant Program support to purchase major upgrades and a refurbishment of our 20-year-old jointly owned and operated 19 MeV cyclotron. The cyclotron is a major component of WCM and MSK strategic investments in crucial imaging infrastructure used to advance basic, translational and clinical research, and is a vital tool for our large and growing pool of investigators who utilize positron emission tomography (PET) in their projects. At this point, all major components of the cyclotron are at or beyond their end of life and are facing end-of-service status due to lack of available parts. In some cases, the components are degraded to the point that catastrophic failure requiring significant downtime and cost is possible in the near term. In addition, in order to support our large and growing pool of NIH funded investigators, we require features that are not available in our current cyclotron configuration. WCM and MSK are world leaders in biomedical research, and our cyclotron partnership over the past 20 years has leveraged the technical expertise of both institutions to ensure efficient radioisotope while realizing the significant benefits of cost sharing. The proposed upgrades and refurbishment will provide us with new state-of-the-art cyclotron technology, including complete replacement of the ion source, radiofrequency, computer control, and target assembly subsystems, that will facilitate innovative research projects using PET over the next two decades. Successful completion of this project will contribute significantly to our goal of understanding and treating a wide range of diseases, including neurodegeneration, cancers, psychiatric disorders, genetic disorders, inflammatory diseases, and vascular diseases. The cyclotron is located at the Citigroup Biomedical Imaging Center (CBIC), which is a dedicated, comprehensive, imaging research and development facility located on the campus of the Medical College. The CBIC operates as an imaging research Core facility that serves over 100 investigators from 12 institutions in the greater New York area. The campus is immediately adjacent to the campus of Memorial Sloan-Kettering Cancer Center. MSK also operates a large imaging Core facility dedicated to oncologic applications. Both institutions have burgeoning imaging research programs with high demand for cyclotron-produced radiotracers used in positron emission tomography (PET). The proposed upgrades and refurbishment are critical to our mission of providing high-level, uninterrupted research support for investigators funded by the National Institutes of Health and other sponsors on both campuses.

项目概要 康奈尔大学威尔医学院 (Weill Cornell Medicine, WCM) 和纪念斯隆管理学院 - 凯特林癌症中心 (MSK) 请求高端仪器补助计划支持购买 对我们共同拥有和运营的已有 20 年历史的 19 MeV 回旋加速器进行重大升级和翻新。 回旋加速器是 WCM 和 MSK 对关键成像基础设施战略投资的主要组成部分 用于推进基础、转化和临床研究，是我们庞大且不断增长的数据库的重要工具 在他们的项目中使用正电子发射断层扫描 (PET) 的研究人员。至此，各大 回旋加速器的部件已达到或超过其使用寿命，并面临由于服务终止状态 缺乏可用零件。在某些情况下，组件会退化到灾难性的程度 短期内可能会出现需要大量停机时间和成本的故障。此外，为了 为了支持我们庞大且不断增长的 NIH 资助的研究人员队伍，我们需要的功能不是 在我们当前的回旋加速器配置中可用。 WCM 和 MSK 是生物医学研究领域的世界领先者， 我们在过去 20 年的回旋加速器合作伙伴关系充分利用了两个机构的技术专长 确保有效的放射性同位素，同时实现成本分摊的显着效益。拟议的升级 翻新将为我们提供最先进的回旋加速器技术，包括完整的 更换离子源、射频、计算机控制和靶组件子系统，这将 促进未来二十年使用 PET 的创新研究项目。顺利完成本次 该项目将为我们理解和治疗多种疾病的目标做出重大贡献，包括 神经退行性疾病、癌症、精神疾病、遗传性疾病、炎症性疾病和血管疾病 疾病。回旋加速器位于花旗集团生物医学成像中心 (CBIC)，这是一个专门的、 综合性影像研究和开发设施位于医学院校园内。这 CBIC 作为影像研究核心设施运营，为来自 12 个机构的 100 多名研究人员提供服务 大纽约地区。该校园紧邻纪念斯隆-凯特琳大学校园 癌症中心。 MSK 斯隆还运营着一家专门用于肿瘤学应用的大型成像核心设施。两个都 机构拥有蓬勃发展的成像研究项目，对回旋加速器生产的放射性示踪剂有很高的需求 用于正电子发射断层扫描（PET）。拟议的升级和翻新对我们至关重要 其使命是为国家资助的研究人员提供高水平、不间断的研究支持 两个校区的卫生研究院和其他赞助商。