New PET/CT System for Human and Non-human Primate Imaging

用于人类和非人类灵长类动物成像的新型 PET/CT 系统

• 批准号: 10632928
• 负责人: DOUGLAS J BALLON
• 金额: $ 200万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632928
• 关键词: 12 year old; Address; Alzheimer' s Disease; Area; Basic Science; Biodistribution; Biomedical Research; Clinical Research; Computed Tomography Scanners; Core Facility; Dedications; Development; Disease; Funding; Genetic Diseases; Genetic Medicine; Goals; Grant; Human; Image; Inflammatory; Infrastructure; Institution; Investments; Malignant Neoplasms; Mental disorders; Mission; Multiple Sclerosis; Nature; Nerve Degeneration; Neurology; New York; Oncology; Organ; Parkinson Disease; Positron-Emission Tomography; Research; Research Personnel; Research Project Grants; Research Support; Stroke; System; Technical Expertise; Technology; Translational Research; Traumatic Brain Injury; United States National Institutes of Health; Universities; Vascular Diseases; Viral Vector; Vision; X-Ray Computed Tomography; biomedical imaging; college; detection sensitivity; frontier; human imaging; imaging facilities; imaging system; innovation; instrument; instrumentation; medical schools; meter; nonhuman primate; operation; precision medicine; programs; research and development; tool

PROJECT SUMMARY Weill Cornell Medical College of Cornell University (WCM) requests High-End Instrumentation Grant Program support to purchase a new positron emission tomography/computed tomography (PET/CT) system for imaging humans and non-human primates. Our PET/CT operations are a major component of WCM strategic investment in crucial imaging infrastructure used to advance basic, translational and clinical research, and provides vital tools for our large and growing pool of investigators who utilize PET/CT in their projects. At this point, our existing PET/CT scanner is 12 years old and cannot handle the demand from our large and growing pool of NIH funded investigators. In addition, we now require features such as a long axial field-of-view that are not available on our current PET/CT configuration. WCM is a world leader in biomedical research, and our PET/CT operations have leveraged the technical expertise of our institution to provide support to 35 PET related research projects including 28 NIH supported grants. The proposed whole-body PET/CT scanner is the Vision Quadra system offered by Siemens Healthineers. This new instrument will provide us with state-of-the-art technology, including a 1 meter axial field of view and greatly increased detection sensitivity that will facilitate innovative research projects using PET/CT over the next two decades. Successful completion of this project will contribute significantly to our goal of understanding and treating a wide range of diseases, including neurodegeneration, cancers, psychiatric disorders, genetic disorders, inflammatory diseases, and vascular diseases. The PET/CT suite would be located at Weill Cornell Medical College’s Citigroup Biomedical Imaging Center (CBIC), which is a dedicated, comprehensive, imaging research and development facility located on the campus of the College. The CBIC operates as an imaging research Core facility that serves over 100 investigators from 12 institutions in the greater New York area. The proposed new scanner is critical to our mission of providing high-level, uninterrupted research support for investigators funded by the National Institutes of Health and other sponsors. The proposed scanner will largely replace our current Siemens Biograph mCT system, since its whole-body coverage will significantly advance our research into questions related to the multi-organ nature of many diseases. The new scanner would be used to address critical problems at the frontiers of neurology, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, stroke, and traumatic brain injury, as well as genetic medicine, including studies of the biodistribution of viral vectors, and the development of precision medicine in oncology.

项目概要 康奈尔大学威尔康奈尔医学院 (WCM) 申请高端仪器补助金 购买新的正电子发射断层扫描/计算机断层扫描 (PET/CT) 的计划支持 用于人类和非人类灵长类动物成像的系统是我们的 PET/CT 操作的主要组成部分。 WCM 对关键成像基础设施进行战略投资，用于推进基础、转化和临床 研究，并为我们大量且不断增长的研究人员提供了重要的工具，他们在他们的研究中使用 PET/CT 目前，我们现有的 PET/CT 扫描仪已使用 12 年，无法满足项目的需求。 我们拥有庞大且不断增长的 NIH 资助研究人员队伍 此外，我们现在还需要诸如 我们当前的 PET/CT 配置无法提供长轴向视野。 生物医学研究领域的领导者，我们的 PET/CT 业务充分利用了我们的技术专长 机构为 35 个 PET 相关研究项目提供支持，其中包括 28 项 NIH 支持的赠款。 拟议的全身 PET/CT 扫描仪是西门子 Healthineers 提供的 Vision Quadra 系统。 新仪器将为我们提供最先进的技术，包括 1 米的轴向视野和 大大提高了检测灵敏度，这将促进使用 PET/CT 的创新研究项目 未来二十年的成功完成将大大有助于我们的理解目标。 并治疗多种疾病，包括神经退行性疾病、癌症、精神疾病、遗传性疾病 PET/CT 套件将位于威尔康奈尔大学。 医学院的花旗集团生物医学影像中心 (CBIC)，是一个专门的、综合性的影像中心 CBIC 位于学院校园内，作为成像机构运营。 研究核心设施为来自大纽约地区 12 个机构的 100 多名研究人员提供服务。 拟议的新型扫描仪对于我们为以下领域提供高水平、不间断的研究支持的使命至关重要 研究人员将主要由美国国立卫生研究院和其他赞助商资助。 取代我们当前的西门子 Biograph mCT 系统，因为其全身覆盖范围将显着提高 我们对与许多疾病的多器官性质相关的问题的研究将是新的扫描仪。 用于解决神经病学前沿的关键问题，包括阿尔茨海默病、帕金森病 疾病、多发性硬化症、中风和创伤性脑损伤，以及遗传医学，包括研究 病毒载体的生物分布以及肿瘤学精准医学的发展。