The Effects of Diet on the Gut Microbiome and Short Chain Fatty Acids

饮食对肠道微生物组和短链脂肪酸的影响

基本信息

批准号：
10891964
负责人：
NOEL T MUELLER
金额：
$ 11.25万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10891964
关键词：
Effects Diet Gut Microbiome Short

项目摘要

PROJECT ABSTRACT Noel Theodore Mueller, PhD, MPH, is an Assistant Professor of Epidemiology at the Johns Hopkins Bloomberg School of Public Health (JHSPH). He seeks a K01 Award to obtain the skill set, knowledge and mentored research experience critical for his transition from an early career scientist adept in conducting secondary data analyses in observational epidemiologic cohorts to an independent scientist who analyzes and conducts trials designed to intervene on microbial communities that contribute to cardiometabolic disease. Two essential components of his transition into research independence are hands-on mentored training in 1) the conduct and design of clinical trials and translational microbiome experiments and 2) the analysis and interpretation of high-dimensional microbiome data. The proposed K01 Career Development plan will accomplish these goals. One of the most exciting areas of investigation related to prevention of cardiometabolic disease pertains to the etiologic role of the diet-gut microbiome relationship. Research on the gut microbiome as a target for prevention and therapy is an intriguing arena for public health because unlike the human genome, the gut microbiome is modifiable. Observational studies, murine models and small trials suggest dietary factors may exert many of their health effects in the host through modification of the gut microbiota. However, large rigorous trials in humans are needed to determine the effect of diet interventions on the gut microbiota, and whether changes to the gut microbiota associate with treatment-related improvements in cardiometabolic health. The overall objective of this application is to examine the effects of dietary interventions on the gut microbiota and their short chain fatty acid metabolites in racially-diverse participants in randomized trial settings. A secondary objective is to explore if diet-induced changes in the gut microbiota and their metabolites are associated with changes in blood pressure. Dr. Mueller will carry out this research in the rich training environment of the Johns Hopkins Welch Center for Prevention, Epidemiology and Clinical Research and the JHSPH Department of Epidemiology, under the collaborative and supportive mentorship of Dr. Lawrence Appel, MD, MPH, Director of the Welch Center and Professor of Medicine and Epidemiology at the JHSOM and JHSPH; and co-mentor Dr. Cynthia Sears, MD, Professor of Medicine in the Division of Infectious Disease and Gastroenterology. With the support of Dr. Mueller’s mentor, co-mentor and advisors, he is well positioned to complete the proposed activities. In addition to leading this research, Dr. Mueller will attend courses, workshops, seminars, scientific meetings, and participate in weekly study activities with his mentors. This mentored training will enable Dr. Mueller to grow into an independent researcher, with expertise in the design, conduct and analysis of microbiome studies, focused on understanding the intersecting role of nutrition and the microbiome in cardiometabolic diseases.

项目摘要 Noel Theodore Mueller 博士、公共卫生硕士是约翰霍普金斯大学彭博公共卫生学院 (JHSPH) 流行病学助理教授。他寻求 K01 奖，以获得对他从早期过渡到关键的技能、知识和指导研究经验。职业科学家擅长对观察流行病学队列进行二次数据分析，而独立科学家则进行三重试验，旨在干预导致心脏代谢疾病的微生物群落，这是他转向研究的两个重要组成部分。独立性是以下方面的实践指导培训：1）临床试验和转化微生物组实验的进行和设计，2）高维微生物组数据的分析和解释。拟议的 K01 职业发展计划将实现这些目标。与预防心脏代谢疾病相关的最令人兴奋的研究领域之一涉及饮食与肠道微生物组关系的病因学作用，以肠道微生物组作为预防和治疗目标的研究对于公共卫生来说是一个有趣的领域，因为与人类不同。基因组、肠道微生物组是可改变的，观察研究、小鼠模型和小型试验表明，饮食因素可能通过改变肠道微生物群对宿主产生许多健康影响，但需要在人类身上进行大规模、严格的试验才能确定。饮食干预对肠道微生物群的影响，以及肠道微生物群的变化是否与治疗相关的心脏代谢健康相关。本申请的总体目标是检查饮食干预对肠道微生物群及其短链脂肪酸的影响。随机试验环境中不同种族参与者的代谢物的第二个目标是探讨饮食引起的肠道微生物群及其代谢物的变化是否与血压变化相关。 Mueller 博士将在约翰·霍普金斯·韦尔奇预防、流行病学和临床研究中心以及 JHSPH 流行病学系丰富的培训环境中，在医学博士、公共卫生硕士、主任 Lawrence Appel 博士的协作和支持指导下开展这项研究韦尔奇中心主任、JHSOM 和 JHSPH 医学和流行病学教授；共同导师 Cynthia Sears 博士（医学博士）、传染病科医学教授在 Mueller 博士的导师、共同导师和顾问的支持下，他有能力完成拟议的活动。除了领导这项研究外，Mueller 博士还将参加课程、研讨会、科学会议和。与导师一起参加每周的研究活动。这种指导培训将使 Mueller 博士成长为一名独立研究人员，拥有微生物组研究的设计、实施和分析方面的专业知识，重点是了解营养和微生物组在微生物学研究中的交叉作用。心脏代谢疾病。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Human Milk Bacteria: Seeding the Infant Gut?

母乳细菌：在婴儿肠道中播种？

DOI：
发表时间：
2020-08-12
期刊：
影响因子：
30.3
作者：
Differding, Moira K;Mueller, Noel T
通讯作者：
Mueller, Noel T

'Vaginal seeding' after a caesarean section provides benefits to newborn children: FOR: Does exposing caesarean-delivered newborns to the vaginal microbiome affect their chronic disease risk? The critical need for trials of 'vaginal seeding' during caesar

剖腹产后的“阴道播种”为新生儿带来好处： FOR：将剖腹产新生儿暴露于阴道微生物群中是否会影响他们患慢性病的风险？

DOI：
发表时间：
2020-01
期刊：
影响因子：
0
作者：
Mueller, Noel T;Dominguez;Appel, Lawrence J;Hourigan, Suchitra K
通讯作者：
Hourigan, Suchitra K

The Microbiome and Men's Health.

微生物组和男性健康。

DOI：
发表时间：
2019
期刊：
影响因子：
9.3
作者：
Platz, Elizabeth A;Liu, Cindy M;Michaud, Dominique S;Mueller, Noel T;Ravel, Jacques
通讯作者：
Ravel, Jacques

Prenatal and Peripartum Exposure to Antibiotics and Cesarean Section Delivery Are Associated with Differences in Diversity and Composition of the Infant Meconium Microbiome.

产前和围产期接触抗生素以及剖腹产与婴儿胎便微生物组的多样性和组成差异相关。

DOI：
发表时间：
2020-01-27
期刊：
影响因子：
4.5
作者：
Wong, Wendy S W;Sabu, Priya;Deopujari, Varsha;Levy, Shira;Shah, Ankit A;Clemency, Nicole;Provenzano, Marina;Saadoon, Reem;Munagala, Akhil;Baker, Robin;Baveja, Rajiv;Mueller, Noel T;Dominguez;Huddleston, Kathi;Niederhuber
通讯作者：
Niederhuber

Higher Diet Quality in African-American Adolescents Is Associated with Lower Odds of Metabolic Syndrome: Evidence from the NHANES.

非裔美国青少年较高的饮食质量与较低的代谢综合征发病率相关：来自 NHANES 的证据。