RC2 - The Vulnerable Aging Research Core (VARC)

RC2 - 脆弱老化研究核心 (VARC)

• 批准号: 10729114
• 负责人: REBECCA L SUDORE
• 金额: $ 22.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729114
• 关键词: Address; Advanced Development; Affect; Aging; Alzheimer' s disease related dementia; American; Area; Capsicum; Caring; Collaborations; Communities; Complex; Consent; Consultations; Data; Data Collection; Dementia; Development; Diabetes Mellitus; Disease; Elderly; Enrollment; Evolution; Faculty; Funding; Future; Geriatrics; Health; Homelessness; Impaired cognition; Impairment; Incidence; Informed Consent; Institutional Review Boards; Interdisciplinary Study; International; Intervention; Knowledge; Measures; Methodology; Methods; Older Population; Outcome; Outcome Measure; Participant; Pharmaceutical Preparations; Population; Poverty; Procedures; Prospective Studies; Protocols documentation; Research; Research Methodology; Research Personnel; Resources; Science; Services; Social isolation; Social support; Testing; Work; community engaged research; design; disability; education research; food insecurity; frailty; health literacy; human subject; implementation science; innovation; literacy; marginally housed; medical vulnerability; multiple chronic conditions; novel; outreach; patient safety; randomized trial; recruit; response; skills; social vulnerability; support tools; theories

PROJECT SUMMARY ABSTRACT — Vulnerable Aging Research Core (VARC) The Vulnerable Aging Research Core (VARC) supports OAIC investigators conducting primary data collection studies that include vulnerable older adults. Older adults are vastly underrepresented in research. This underrepresentation is even more pronounced for older adults with medical vulnerability (e.g., cognitive impairment and complex multi-morbidity) and/or social vulnerability (e.g., isolation, poverty, limited health literacy, homelessness). These medical and social vulnerabilities often coexist and interact to produce profound effects on disease incidence, progression, outcomes, and response to health interventions. Yet, older adults with these vulnerabilities are often difficult to recruit and retain, adversely affecting their representation in research and impairing our knowledge of how best to optimize their care. The UCSF Pepper Center has an international reputation for expertise in the recruitment, retention, and protection of medically and socially vulnerable older adults in research including in community-engaged research, prospective studies, and randomized trials. Since the VARC's inception last cycle, the number of OAIC investigators engaged in primary data collection of medically and socially vulnerable older adults has continued to grow exponentially, as have the services we provide to investigators. We propose the following aims: (1) Provide expert consultation for the design of primary data collection studies that focus on older adults with medical and/or social vulnerabilities, including human subject considerations; (2) Support OAIC-affiliated investigators on methods for recruiting, consenting, enrolling, and retaining vulnerable older adults, including convening and maintaining community advisory boards; (3) Support OAIC investigators on methods to develop and test interventions that are responsive to the needs and priorities of vulnerable older adults; (4) Advise on the incorporation of predictor and outcome measures of medical and social vulnerability (e.g., cognitive impairment, frailty, health literacy, poverty, social isolation) in collaboration with the Data and Analysis Core; and (5) Support Development Projects that advance the development of new methodologies in our Core's theme area. We propose a novel Development Project to develop innovative methods for merging qualitative and mixed methods data across studies involving older adults with disability and their care partners and clinicians. The VARC will also support stellar external investigators whose research involves recruiting and retaining vulnerable older adults. Proposed external projects include NIA-funded studies exploring barriers to long-term social support services for older adults with Alzheimer's Disease and Related Dementias and the effects of a novel decision support tool to help older adults discuss diabetes medication deprescribing with clinicians.

项目摘要 摘要 — 脆弱老化研究核心 (VARC) 弱势老龄化研究核心 (VARC) 支持 OAIC 研究人员进行主要数据收集 包括弱势老年人在内的研究中，老年人的代表性严重不足。 对于患有医疗脆弱性（例如认知障碍）的老年人来说，代表性不足的情况更为明显 损伤和复杂的多发病）和/或社会脆弱性（例如孤立、贫困、健康状况不佳） 这些医疗和社会脆弱性往往共存并相互作用产生。 对疾病发生率、进展、结果和对健康干预措施的反应的广泛影响。 具有这些弱点的成年人往往难以招募和留住，从而对其代表性产生不利影响 加州大学旧金山分校胡椒中心 (UCSF Pepper Center) 在招募、保留和保护医疗和社会方面的专业知识方面享有国际声誉 弱势老年人参与研究，包括社区参与研究、前瞻性研究和 自上个周期 VARC 启动以来，参与初级研究的 OAIC 研究人员数量。 对医疗和社会弱势老年人的数据收集继续呈指数增长， 我们为研究者提供的服务提出以下目标： (1) 为研究者提供专家咨询。 主要数据收集研究的设计，重点关注患有医疗和/或社会疾病的老年人 (2) 支持 OAIC 附属研究人员的方法 招募、同意、登记和保留弱势老年人，包括召集和登记维持 社区咨询委员会；(3) 支持 OAIC 调查人员制定和测试干预措施， (4) 就设立公司提出建议 医疗和社会脆弱性的预测指标和结果指标（例如认知障碍、虚弱、健康状况） 识字、贫困、社会孤立）与数据和分析核心合作；以及 (5) 支持； 推动我们核心主题领域新方法开发的开发项目。 提出一个新颖的开发项目，以开发融合定性和混合的创新方法 涉及残疾老年人及其护理伙伴和顾客的研究中的方法数据。 VARC 还将支持优秀的外部研究人员，他们的研究涉及招募和保留 拟议的外部项目包括 NIA 资助的研究，探讨长期障碍。 为患有阿尔茨海默病和相关痴呆症的老年人提供的社会支持服务以及 新颖的决策支持工具，可帮助老年人与圣徒讨论糖尿病药物的处方。