VARC Core

VARC 核心

基本信息

批准号：
10434053
负责人：
REBECCA L SUDORE
金额：
$ 18.2万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10434053
关键词：
Accounting Address Affect Aging American Benefits and Risks Caring Collaborations Communities Complex Consent Consultations Data Data Analyses Data Collection Dementia Development Disease Elderly Enrollment Ensure Faculty Geriatrics Health Homelessness Impaired cognition Impairment Incidence Informed Consent Institutional Review Boards International Intervention Knowledge Logistics Longitudinal cohort Longitudinal cohort study Measurement Measures Medical Mentorship Methods Outcome Outcome Measure Participant Poverty Procedures Protocols documentation Proxy Research Research Design Research Personnel Social isolation Training Vulnerable Populations Work community engagement design education resources efficacy trial food insecurity frailty health literacy human subject improved literacy marginally housed medical vulnerability multiple chronic conditions novel outcome prediction outreach patient safety pragmatic trial randomized trial recruit research study response skills social social vulnerability young adult

项目摘要

Project Summary: The Vulnerable Aging Recruitment and Retention Core (VARC) Older adults are vastly underrepresented in research. This underrepresentation is even more pronounced for older adults with medical vulnerability (e.g., cognitive impairment and complex multi-morbidity) and/or social vulnerability (e.g., isolation, poverty, limited literacy or homelessness). These medical and social vulnerabilities often coexist and interact to produce profound effects on disease incidence, progression, outcomes, and response to health interventions. Yet older adults with these vulnerabilities are often difficult to recruit and retain, adversely affecting their representation in research and impairing our knowledge of how best to optimize their care. The UCSF Division of Geriatrics has an international reputation for expertise in the recruitment, retention, and protection of vulnerable older adults in research including in longitudinal cohorts and randomized trials. In our first cycle, the UCSF Older Adults Independence Center (OAIC) greatly expanded its support of the recruitment and retention of vulnerable older adults across UCSF. To build on this progress and meet the increased demand for our expertise, we propose to create a dedicated core: The Vulnerable Aging Recruitment and Retention Core (VARC). We propose the following aims: 1) Provide expert consultation for the design (e.g., pilots, longitudinal cohorts, and efficacy and pragmatic trials) and Institutional Review Board considerations for primary data collection studies that focus on older adults with medical and/or social vulnerabilities; 2) Support OAIC investigators on methods for recruiting, enrolling, and retaining vulnerable older adults, including appropriate informed consent procedures and the creation of community advisory boards; 3) Establish administrative, mentorship and educational resources to train OAIC-affiliated researchers and staff concerning the logistics of recruitment, enrollment, and consent of vulnerable populations; 4) Advise on the incorporation of predictor and outcome measures of medical vulnerability (e.g., cognitive impairment, frailty) and social vulnerability (e.g., health literacy, poverty, social isolation, etc.) in collaboration with the Data and Analysis Core. 5) Support development projects that create novel methods for improving recruitment and retention of vulnerable older adults into research studies.

项目摘要：弱势老龄化招聘和保留核心 (VARC) 老年人在研究中的代表性严重不足。这种代表性不足的情况更为明显患有医疗脆弱性（例如认知障碍和复杂的多发病）和/或社交的老年人脆弱性（例如孤立、贫困、识字能力有限或无家可归）。这些医疗和社会脆弱性通常共存并相互作用，对疾病的发生、进展、结果和结果产生深远的影响对健康干预措施的反应。然而，具有这些弱点的老年人往往很难招募和招募保留，对他们在研究中的代表性产生不利影响，并削弱我们对如何最好地优化的了解他们的关心。加州大学旧金山分校老年病学部在招募、在纵向队列和随机研究中保留和保护弱势老年人试验。在我们的第一个周期中，加州大学旧金山分校老年人独立中心 (OAIC) 极大地扩大了对以下群体的支持：加州大学旧金山分校招募和保留弱势老年人。为了在此基础上再接再厉并满足对我们专业知识的需求增加，我们建议创建一个专门的核心：脆弱老龄化招聘和保留核心（VARC）。我们提出以下目标： 1) 为设计提供专家咨询（例如试点、纵向队列、有效性和务实性）试验）和机构审查委员会对关注老年人的主要数据收集研究的考虑具有医疗和/或社会脆弱性的成年人； 2) 支持 OAIC 调查人员招募、登记和保留弱势老年人的方法，包括适当的知情同意程序和社区咨询委员会的设立； 3) 建立行政、指导和教育资源来培训 OAIC 附属研究人员和工作人员关于弱势群体的招募、入学和同意的后勤工作； 4) 就医疗脆弱性的预测指标和结果指标的纳入提出建议（例如认知能力）损伤、虚弱）和社会脆弱性（例如健康素养、贫困、社会孤立等）的合作与数据和分析核心。 5) 支持开发项目，创造新的方法来改善招聘和保留弱势老年人参与研究。