High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin Supplement

用于行为动物图像引导神经调节的高分辨率双向光声介观神经接口 - RF1 管理补充

• 批准号: 10712937
• 负责人: Robert E. Campbell
• 金额: $ 42.38万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712937
• 关键词: Acoustics; Alzheimer' s Disease; Animals; Blood Vessels; Brain; Brain Mapping; Brain imaging; Cerebrospinal Fluid; Diagnosis; Goals; Image; Imaging Techniques; Neurosciences; Optics; Proteins; Regulation; Resolution; Structure; System; Therapeutic; Tissues; Transgenic Model; Ultrasonic wave; Waste Products; cerebrospinal fluid flow; glymphatic system; image guided; imaging modality; in vivo imaging; nervous system disorder; neural; neuroregulation; novel; photoacoustic imaging; protein aggregation; tool

ABSTRACT Neuroscience has an essential requirement for large-scale imaging and perturbation tools. Such tools would be transformative in the mapping of brain function and the diagnosis and treatment of neurological disorders. The proposed project is aimed at uncovering regulation of glymphatic and vascular flow in the progression of Alzheimer’s disease (AD) at whole-brain, cellular-resolution scales using novel whole-brain imaging modalities. Our project’s goal is to use state-of-the-art in vivo imaging techniques to study cerebrospinal fluid (CSF) flow in the brain, and how this flow interacts with AD-related protein accumulation in transgenic models. We will study how flow in this system is perturbed in AD, with a focus on clearance of waste products

抽象的 神经科学对大规模成像和微扰工具有基本要求。 这些工具将在大脑功能图谱以及诊断和诊断方面带来变革。 拟议的项目旨在揭示神经系统疾病的调节。 阿尔茨海默氏病（AD）全脑进展中的类淋巴管和血管血流， 我们项目的目标是使用新颖的全脑成像方式进行细胞分辨率缩放。 最先进的体内成像技术，用于研究大脑中的脑脊液 (CSF) 流动，以及 我们将研究这种流动如何与转基因模型中 AD 相关的蛋白质积累相互作用。 AD 中该系统的流动如何受到干扰，重点是废物的清除

项目成果

Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.

使用荧光标记的红细胞进行全皮层经颅定位显微镜检查。

• 发表时间: 2024-04-25
• 影响因子: 16.6
• 作者: Zhou, Quanyu;Glück, Chaim;Tang, Lin;Glandorf, Lukas;Droux, Jeanne;El Amki, Mohamad;Wegener, Susanne;Weber, Bruno;Razansky, Daniel;Chen, Zhenyue
• 通讯作者: Chen, Zhenyue

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.

体内帕金森病 M83 小鼠模型中 α-突触核蛋白和铁沉积的可视化。

• 发表时间: 2023-06-30
• 作者: Straumann, Nadja;Combes, Benjamin F;Dean Ben, Xose Luis;Sternke;Gerez, Juan A;Dias, Ines;Chen, Zhenyue;Watts, Benjamin;Rostami, Iman;Shi, Kuangyu;Rominger, Axel;Baumann, Christian R;Luo, Jinghui;Noain, Daniela;Nitsch, Roger
• 通讯作者: Nitsch, Roger

Deep optoacoustic localization microangiography of ischemic stroke in mice.

小鼠缺血性中风的深度光声定位微血管造影。

• 发表时间: 2023-06-16
• 影响因子: 16.6
• 作者: Deán;Robin, Justine;Nozdriukhin, Daniil;Ni, Ruiqing;Zhao, Jim;Glück, Chaim;Droux, Jeanne;Sendón;Chen, Zhenyue;Zhou, Quanyu;Weber, Bruno;Wegener, Susanne;Vidal, Anxo;Arand, Michael;El Amki, Mohamad;Razansky, Daniel
• 通讯作者: Razansky, Daniel

Multi-Scale Volumetric Dynamic Optoacoustic and Laser Ultrasound (OPLUS) Imaging Enabled by Semi-Transparent Optical Guidance.

通过半透明光学制导实现多尺度体积动态光声和激光超声 (OPLUS) 成像。

• 发表时间: 2024-03
• 作者: Nozdriukhin, Daniil;Kalva, Sandeep Kumar;Özsoy, Cagla;Reiss, Michael;Li, Weiye;Razansky, Daniel;Deán
• 通讯作者: Deán