Probing Amygdalo-Cortical Circuitry in Anxiety Disorders

探索焦虑症中的杏仁核皮质回路

• 批准号: 7743827
• 负责人: SCOTT L RAUCH
• 金额: $ 22.99万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743827
• 关键词: Amygdaloid structure; Animal Phobia; Anterior; Anxiety Disorders; Area; Attenuated; Brain; Brain region; Clinical; Cognitive; Data; Dimensions; Disease; Emotional; Exhibits; Face; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Hippocampus (Brain); Magnetic Resonance Imaging; Maps; Masks; Measures; Medial; Methods; Modeling; Names; Panic Disorder; Patients; Post-Traumatic Stress Disorders; Prefrontal Cortex; Principal Investigator; Relative (related person); Research; Sampling; Severities; Specific Phobia; Specificity; Stimulus; Structure; Structure-Activity Relationship; Surface; Symptoms; System; Techniques; Testing; Thick; Trauma; cingulate cortex; comparison group; face mask; imaging Segmentation; indexing; innovation; neuroimaging; programs; response

DESCRIPTION (provided by applicant): We propose to investigate the pathoDhvsiology of three anxiety disorders: posttraumatic stress disorder (PTSD) panic disorder (PD). and specific phobia (SP). We will use cognitive activation paradigms and magnetic resonance imaging (MRI) to probe the function and structure of implicated amygdalo-cortical circuitry. Convergent data implicate amygdalo- cortical circuitry in the pathophysiology of anxiety disorders. For example, one model of PTSD posits exaggerated amygdala responsivity to threat-related stimuli as well as deficient top-down modulation of amygdala responses by specific cortical regions, including pregenual anterior cingulate cortex, subcallosal cortex, and hippocampus. Though convergent data from neuroimaging studies support this model, we propose to extend this line of research in several respects: 1) use an approach that enables the characterization of habituation/sensitization of amygdala response, to investigate this temporal dimension. Preliminary data suggest that both PTSD and PD may be characterized by sensitization (vs. habituation) of amygdala responses to threat-related stimuli. 2) measure perigenual cortical and amygdala function in the same subjects, to enable a quantitative assessment of the relationship between these brain regions. Such a systems level approach is necessary if pathophysiology or correlates of clinical indices are related to inter-regional interactions. 3) investigate the relationship between abnormal brain structure and abnormal function; we plan to use modern cortical parcellation methods and a new technique for measuring cortical thickness. The cortical thickness method will enable us to: A) decompose volumetric differences to determine the relative contributions of cortical thickness and cortical surface area, and B) map the topographic concordance between observed functional and structural differences. 4) study psychiatric comparison groups, in addition to normal comparison and trauma-exposed normal comparison subjects, in order to determine the specificity (vs. generalizability) of findings among these anxiety disorders.

描述（由申请人提供）：我们建议研究三种焦虑症的病理学学：创伤后应激障碍（PTSD）恐慌症（PD）。和特定的恐惧症（SP）。我们将使用认知激活范例和磁共振成像（MRI）来探测与杏仁核 - 皮质电路相关的功能和结构。收敛数据暗示杏仁核和焦虑症的病理生理中的杏仁核回路。例如，一种PTSD的模型假设夸张的杏仁核对威胁相关的刺激的反应性以及特定皮质区域对杏仁核反应的自上而下的调节，包括前扣前扣带回皮质，亚果salosalsosalsosal corortex和Hippocampus。尽管来自神经成像研究的收敛数据支持了该模型，但我们建议在几个方面扩展这一研究线：1）使用一种方法来表征杏仁核反应的习惯/敏化，以研究这一时间维度。初步数据表明，PTSD和PD的特征都以杏仁核对威胁相关刺激的反应的敏感性（与习惯）的特征。 2）在同一受试者中测量阴性皮质和杏仁核功能，以对这些大脑区域之间的关系进行定量评估。如果病理生理学或临床指数的相关性与区域间相互作用有关，则必须采用这种系统水平方法。 3）研究脑结构异常和异常功能之间的关系；我们计划使用现代的皮质细化方法和一种测量皮质厚度的新技术。皮质厚度方法将使我们能够：a）分解体积差异以确定皮质厚度和皮质表面积的相对贡献，b）映射观察到的功能差异和结构差异之间的地形一致性。 4）研究精神比较组，除了正常的比较和暴露于正常比较主题外，还可以确定这些焦虑症中发现的特异性（相对于概括性）。

项目成果

Cortico-limbic responses to masked affective faces across ptsd, panic disorder, and specific phobia.

• DOI: 10.1002/da.22156
• 发表时间: 2014-02
• 期刊: Depression and anxiety
• 影响因子: 7.4
• 作者: Killgore WD;Britton JC;Schwab ZJ;Price LM;Weiner MR;Gold AL;Rosso IM;Simon NM;Pollack MH;Rauch SL
• 通讯作者: Rauch SL

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder.

• DOI: 10.1016/j.janxdis.2013.04.004
• 发表时间: 2013-05
• 期刊: JOURNAL OF ANXIETY DISORDERS
• 影响因子: 10.3
• 作者: Weber, Mareen;Killgore, William D. S.;Rosso, Isabelle M.;Britton, Jennifer C.;Schwab, Zachary J.;Weiner, Melissa R.;Simon, Naomi M.;Pollack, Mark H.;Rauch, Scott L.
• 通讯作者: Rauch, Scott L.

Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm.

• DOI: 10.1002/da.20569
• 发表时间: 2009
• 期刊: DEPRESSION AND ANXIETY
• 影响因子: 7.4
• 作者: Britton, Jennifer C.;Gold, Andrea L.;Deckersbach, Thilo;Rauch, Scott L.
• 通讯作者: Rauch, Scott L.

Neural correlates of anxiety sensitivity during masked presentation of affective faces.

• DOI: 10.1002/da.20788
• 发表时间: 2011-03
• 期刊: DEPRESSION AND ANXIETY
• 影响因子: 7.4
• 作者: Killgore, William D. S.;Britton, Jennifer C.;Price, Lauren M.;Gold, Andrea L.;Deckersbach, Thilo;Rauch, Scott L.
• 通讯作者: Rauch, Scott L.