BASAL GANGLIA FUNCTION IN OBSESSIVE COMPULSIVE DISORDER

强迫症中的基底神经节功能

• 批准号: 2884959
• 负责人: SCOTT L RAUCH
• 金额: $ 28.87万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884959
• 关键词: basal ganglia; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; cerebral dominance; clinical research; cognition; corpus striatum; disease /disorder classification; functional magnetic resonance imaging; human middle age (35-64); human subject; learning; memory; mental disorder diagnosis; neural information processing; neuropathology; neuropsychology; obsessive compulsive disorder; psychomotor function; remission /regression; thalamus; visual stimulus; young adult human (21-34)

The goals of this project are to test specific hypotheses about the pathophysiology of obsessive compulsive disorder (OCD) using functional MRI (fMRI) and cognitive neuroscience methods. The basal ganglia have been implicated in the pathophysiology of OCD and also in the normal mediating anatomy of implicit (i.e., nonconscious) learning. We have developed an fMRI paradigm to measure activity within components of the basal ganglia during the performance of an implicit learning task. In preliminary functional imaging studies, we have observed an abnormal activation profile in medication-free subjects with current OCD. Specifically, in comparison to normal control subjects, patients with OCD exhibit a failure to activate right striatum, and an absence of thalamic deactivation, as well as aberrent medial temporal activation (i.e., not found in normal subjects). These results are consistent with evolving neurobiological models of OCD and basal ganglia function. The current proposal aims to: 1) use this fMRI paradigm to replicate and elaborate upon the above findings in a larger cohort of medication-free patients with active OCD and matched normal comparison subjects; 2) determine the specificity of the findings in OCD by studying psychiatric comparison subjects; and 3) further investigate the neuropsychological consequences of the abnormal activation profile observed in OCD. It is anticipated that this approach will yield new information regarding the pathophysiology of OCD and related disorders, while providing new insights about the normal function of the basal ganglia and the mediating anatomy of normal learning.

该项目的目标是测试有关使用功能MRI（fMRI）和认知神经科学方法的强迫症（OCD）病理生理学的特定假设。 基底神经节与强迫症的病理生理学以及正常的隐式解剖结构（即无意识）学习有关。 我们已经开发了功能磁共振成像范式，以测量在执行隐式学习任务期间基底神经节组件内的活动。 在初步功能成像研究中，我们观察到无药OCD的无药物受试者的异常激活曲线。具体而言，与正常对照受试者相比，强迫症患者表现出无法激活右纹状体，缺乏丘脑失活以及异常的内侧时间激活（即在正常受试者中未发现）。 这些结果与OCD和基底神经节功能的神经生物学模型不断发展。 当前的提案旨在：1）使用此功能磁共振成像范式复制并详细说明较大的无药物活性强迫症患者并匹配正常比较受试者中的上述发现； 2）通过研究精神病学比较主题来确定强迫症中发现的特异性； 3）进一步研究了OCD中观察到的异常激活概况的神经心理学后果。 可以预料，这种方法将产生有关强迫症和相关疾病的病理生理学的新信息，同时提供有关基底神经节正常功能以及正常学习的介导解剖结构的新见解。