The Anterior Cingulate Cortex's Role in Normal Socioemotional Behavior

前扣带皮层在正常社会情感行为中的作用

基本信息

批准号：
8465938
负责人：
Eliza Bliss-Moreau
金额：
$ 5.57万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8465938
关键词：
Address Adult Amygdaloid structure Animal Testing Animals Anterior Anxiety Area Arousal Autistic Disorder Autonomic nervous system Behavior Behavioral Bilateral Biological Neural Networks Bipolar Disorder Brain Brain region Code Cognitive Commit Complex Conflict (Psychology)Control Animal Cues Detection Diagnosis Disease Emotional Environment Etiology Fiber Frequencies Fright Functional disorder Future Generations Goals Heart Rate Human Ibotenic Acid Impairment Lesion Macaca Macaca mulatta Magnetic Resonance Imaging Measures Mental Depression Mental Health Mental disorders Methods Monkeys Moods Nature Operative Surgical Procedures Organism Performance Peripheral Physiological Physiology Play Post-Traumatic Stress Disorders Prefrontal Cortex Probability Process Production Rattus Reaction Reaction Time Regulation Research Respiration Rewards Role Sensory Signal Transduction Social Behavior Social Interaction Social Phobia Stimulus Structure System Variant Visual Work affiliative behavior base cingulate cortex cohort developmental disease dyadic interaction effective therapy emotional experience emotional stimulus heart rate variability interest male mature animal neurotoxic novel operation relating to nervous system research study response sensory stimulus social social group species typical behavior therapy design

项目摘要

DESCRIPTION (provided by applicant): Elucidating the components of the socioemotional brain and understanding their contribution to the generation of species typical behavior is germane to understanding and developing effective treatments for a host of mental health and developmental disorders. The proposed work investigates the role of one brain structure, the anterior cingulate cortex (ACC), in normal social and emotional behavior (Specific Aim 1). The ACC has been implicated in a wide array of social and emotional processing in humans and nonhuman animals. Lesion studies in rats and monkeys typically use destructive lesions of the ACC and then test animals in constrained non-naturalistic tasks of social and emotional processing. There are a number of issues with these approaches that are specifically addressed in the proposed projects by using fiber-sparing ibotenic acid lesions and testing animals in semi-naturalistic social and emotional task environments. A cohort of adult rhesus macaques will receive either bilateral, ibotenic acid lesions of the anterior cingulate cortex or sham operations. Animals will complete a battery of semi-naturalistic social and emotional processing tasks during which the frequency and duration of their spontaneously generated behaviors will be captured using a robust behavioral ethogram. A secondary goal of the proposed work is to relate deficiencies in social and emotional process resulting from ACC damage to deficiencies in other ACC-related functions: processing competing or conflicting stimuli (Specific Aim 2) and generating physiological responses (Specific Aim 3). The ACC is widely thought to process competing stimulus inputs in order to execute coherent behavioral responses; this function is likely critical for normal social behavior (e.g., processing affiliative and aggressive signals within a complex social group). The ACC is also thought to be involved in generating and regulating peripheral physiological responses such as changes in heart rate and respiration; this function is likely critical for normal emotional behavior (e.g., experiencing emotional states that are physiologically arousing such as fear or anxiety). Following Specific Aim 1, experimental animals will complete two tasks to address Specific Aims 2 and 3. First, animals will complete a cognitive task during which competing sensory inputs must be resolved to execute the correct behavioral response. Second, animals will complete a task in which they watch socioemotionally provocative videos while their peripheral physiology is measured. Lesioned and control animals' performance on these tasks will be compared and also used as a variable in analyses of social and emotional behavior (from tasks related to Specific Aim 1).

描述（由申请人提供）：阐明社会情感大脑的组成部分，并理解它们对物种典型行为的贡献是与理解和开发有效的精神健康和发育障碍的有效治疗的贡献。拟议的工作调查了一种大脑结构，前扣带回皮层（ACC）在正常的社会和情感行为中的作用（特定目标1）。 ACC已与人类和非人类动物的各种社会和情感处理有关。在大鼠和猴子中的病变研究通常使用ACC的破坏性病变，然后在社会和情感处理的非自然主义任务中测试动物。这些方法在拟议的项目中使用纤维的伊布宁酸病变和在半自然主义的社会和情感任务环境中测试动物，这些方法有许多问题。一群成年恒河猕猴将接受前扣带回皮层的双侧，依抗酸性病变或假手术。动物将完成一系列半自然主义的社交和情感处理任务，在此任务中，它们的自发行为的频率和持续时间将使用强大的行为伦理图捕获。拟议工作的第二个目标是将ACC损害损害导致的社会和情感过程中的缺陷与其他与ACC相关功能的缺陷产生的缺陷联系起来：处理竞争或相互冲突的刺激（特定目标2）并产生生理反应（特定目标3）。广泛认为ACC处理竞争刺激输入以执行连贯的行为反应；此功能对于正常的社会行为可能至关重要（例如，在复杂的社会群体中处理从属关系和积极的信号）。 ACC还被认为参与产生和调节外周生理反应，例如心率和呼吸的变化；该功能对于正常的情绪行为可能至关重要（例如，经历在生理上引起诸如恐惧或焦虑之类的情绪状态）。在特定目标1之后，实验动物将完成两项任务以解决特定的目标2和3。首先，动物将完成一项认知任务，在此任务中，必须解决竞争性的感觉输入以执行正确的行为响应。其次，动物将完成一项任务，在这些任务中，他们在测量周围生理学的同时观看社会情感挑衅性的视频。将比较病变和控制动物在这些任务上的表现，并将其用作社会和情感行为分析的变量（从与特定目标相关的任务1）。