The Anterior Cingulate Cortex's Role in Normal Socioemotional Behavior

前扣带皮层在正常社会情感行为中的作用

• 批准号: 8121873
• 负责人: Eliza Bliss-Moreau
• 金额: $ 5.3万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8121873
• 关键词: Address; Adult; Amygdaloid structure; Animal Testing; Animals; Anterior; Anxiety; Area; Arousal; Autistic Disorder; Autonomic nervous system; Behavior; Behavioral; Bilateral; Biological Neural Networks; Bipolar Disorder; Brain; Brain region; Code; Cognitive; Commit; Complex; Conflict (Psychology); Control Animal; Cues; Detection; Diagnosis; Disease; Emotional; Environment; Etiology; Fiber; Frequencies; Fright; Functional disorder; Future; Generations; Goals; Heart Rate; Human; Ibotenic Acid; Impairment; Lesion; Macaca; Macaca mulatta; Magnetic Resonance Imaging; Measures; Mental Depression; Mental Health; Mental disorders; Methods; Monkeys; Moods; Nature; Operative Surgical Procedures; Organism; Performance; Peripheral; Physiological; Physiology; Play; Post-Traumatic Stress Disorders; Prefrontal Cortex; Probability; Process; Production; Rattus; Reaction; Reaction Time; Regulation; Research; Respiration; Rewards; Role; Sensory; Signal Transduction; Social Behavior; Social Interaction; Social Phobia; Stimulus; Structure; System; Variant; Visual; Work; affiliative behavior; base; cingulate cortex; cohort; developmental disease; dyadic interaction; effective therapy; emotional experience; emotional stimulus; heart rate variability; interest; male; mature animal; neurotoxic; novel; operation; relating to nervous system; research study; response; sensory stimulus; social; social group; species typical behavior; therapy design

DESCRIPTION (provided by applicant): Elucidating the components of the socioemotional brain and understanding their contribution to the generation of species typical behavior is germane to understanding and developing effective treatments for a host of mental health and developmental disorders. The proposed work investigates the role of one brain structure, the anterior cingulate cortex (ACC), in normal social and emotional behavior (Specific Aim 1). The ACC has been implicated in a wide array of social and emotional processing in humans and nonhuman animals. Lesion studies in rats and monkeys typically use destructive lesions of the ACC and then test animals in constrained non-naturalistic tasks of social and emotional processing. There are a number of issues with these approaches that are specifically addressed in the proposed projects by using fiber-sparing ibotenic acid lesions and testing animals in semi-naturalistic social and emotional task environments. A cohort of adult rhesus macaques will receive either bilateral, ibotenic acid lesions of the anterior cingulate cortex or sham operations. Animals will complete a battery of semi-naturalistic social and emotional processing tasks during which the frequency and duration of their spontaneously generated behaviors will be captured using a robust behavioral ethogram. A secondary goal of the proposed work is to relate deficiencies in social and emotional process resulting from ACC damage to deficiencies in other ACC-related functions: processing competing or conflicting stimuli (Specific Aim 2) and generating physiological responses (Specific Aim 3). The ACC is widely thought to process competing stimulus inputs in order to execute coherent behavioral responses; this function is likely critical for normal social behavior (e.g., processing affiliative and aggressive signals within a complex social group). The ACC is also thought to be involved in generating and regulating peripheral physiological responses such as changes in heart rate and respiration; this function is likely critical for normal emotional behavior (e.g., experiencing emotional states that are physiologically arousing such as fear or anxiety). Following Specific Aim 1, experimental animals will complete two tasks to address Specific Aims 2 and 3. First, animals will complete a cognitive task during which competing sensory inputs must be resolved to execute the correct behavioral response. Second, animals will complete a task in which they watch socioemotionally provocative videos while their peripheral physiology is measured. Lesioned and control animals' performance on these tasks will be compared and also used as a variable in analyses of social and emotional behavior (from tasks related to Specific Aim 1). PUBLIC HEALTH RELEVANCE: diagnosis and treatment of mental health disorders (e.g., anxiety, depression) and social processing disorders (e.g., autism, social phobia) require a clear understanding of "the socioemotional brain". The socioemotional brain is made up of several brain structures and neural systems that allow social and emotional information to be perceived, further processed, and ultimately used to produce normal behavior. The proposed work investigates the role of one brain region, the anterior cingulate cortex, in the production and regulation of socioemotional behavior in rhesus monkeys.

描述（由申请人提供）：阐明社会情感大脑的组成部分并了解它们对物种典型行为产生的贡献对于理解和开发针对许多心理健康和发育障碍的有效治疗方法密切相关。拟议的工作调查了一种大脑结构，即前扣带皮层 (ACC) 在正常社交和情感行为中的作用（具体目标 1）。 ACC 与人类和非人类动物的一系列社会和情感处理有关。对大鼠和猴子的损伤研究通常使用 ACC 的破坏性损伤，然后在社交和情感处理的受限非自然任务中测试动物。这些方法存在许多问题，在拟议的项目中通过使用保留纤维的鹅膏菌酸损伤并在半自然的社交和情感任务环境中测试动物来具体解决这些问题。一群成年恒河猴将接受前扣带皮层双侧鹅膏酸损伤或假手术。动物将完成一系列半自然主义的社交和情感处理任务，在此期间，它们自发产生的行为的频率和持续时间将使用强大的行为行为图来捕获。拟议工作的第二个目标是将 ACC 损伤导致的社交和情感过程缺陷与其他 ACC 相关功能的缺陷联系起来：处理竞争或冲突的刺激（具体目标 2）并产生生理反应（具体目标 3）。人们普遍认为 ACC 可以处理竞争性刺激输入，以执行连贯的行为反应；该功能可能对于正常的社会行为至关重要（例如，在复杂的社会群体中处理亲和和攻击性信号）。 ACC 还被认为参与产生和调节外周生理反应，例如心率和呼吸的变化；该功能可能对于正常的情绪行为（例如，经历生理上引起的情绪状态，如恐惧或焦虑）至关重要。遵循特定目标 1，实验动物将完成两项任务来解决特定目标 2 和 3。首先，动物将完成一项认知任务，在此期间必须解决相互竞争的感官输入以执行正确的行为反应。其次，动物将完成一项任务，在其中观看社会情感挑衅性视频，同时测量其周围生理机能。将比较受损动物和对照动物在这些任务中的表现，并将其用作社会和情感行为分析的变量（来自与特定目标 1 相关的任务）。 公共卫生相关性：精神健康障碍（例如焦虑、抑郁）和社会处理障碍（例如自闭症、社交恐惧症）的诊断和治疗需要对“社会情感大脑”有清晰的了解。社会情感大脑由多种大脑结构和神经系统组成，这些结构和神经系统允许社会和情感信息被感知、进一步处理并最终用于产生正常行为。这项拟议的工作研究了一个大脑区域，即前扣带皮层，在恒河猴社会情绪行为的产生和调节中的作用。