Efficient snap-shot CT imaging of the entire heart using staggered circular scans

使用交错圆形扫描对整个心脏进行高效快照 CT 成像

基本信息

批准号：
7880625
负责人：
Frederic Noo
金额：
$ 18.62万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7880625
关键词：
Address Advertising Algorithms Angiography Area Body Image Breathing Cardiac Complement Computer Simulation Computers Coronary Coronary artery Data Development Diagnostic Dose Evaluation Freezing Goals Heart Human Image Knowledge Low Dose Radiation Marketing Measurement Morphologic artifacts Motion Noise Patients Performance Plant Roots Relative (related person)Research Proposals Resolution Retinal Cone Rotation Scanning Simulate Solutions Somatotype Source Speed Stenosis System Technology Tomography, Computed, Scanners Translations Validation X-Ray Computed Tomography base comparative coronary computed tomography angiography cost data acquisition design detector heart motion image reconstruction improved indexing innovation interest patient population prevent prototype public health relevance reconstruction simulation theories tomography tool

项目摘要

DESCRIPTION (provided by applicant): We are interested in x-ray computed tomography (CT) imaging of the coronary arteries, commonly referred to as coronary CT angiography (CTA). Specifically, we suggest an innovative, low-cost solution to the problem of performing accurate coronary CTA within a single heartbeat. This solution is the result of combining the latest advances in image reconstruction theory with careful system design considerations. More specifically, we propose to mitigate artifacts occurring with circular CB tomography of the entire heart, using (i) a new concept of scans, called staggered circular scans, that use several x-ray sources together to obtain CB data on parallel circular trajectories for the net effect of reducing the cone angle without requiring axial motion, (ii) innovative reconstruction algorithms that draw on recent advances in image reconstruction theory. Staggered circular scans are defined with an index K that gives the number of x-ray sources involved. We will focus our effort on the following aims: (1) Development, implementation and validation of a preferred reconstruction algorithm for accurate coronary CTA using staggered circular scans of index K = 2, K = 3 and K = 4. (2) Comparative evaluation of staggered circular scans against each other and against the conventional circular data acquisition. (3) Demonstration of robustness for real data. (4) Feasibility demonstration of accurate general body imaging with a scanner designed to perform staggered circular scans. PUBLIC HEALTH RELEVANCE: NARRATIVE This proposal aims at allowing a leap forward in technology so that cardiac CT imaging can be achieved consistently (i.e., independently of the patient heart's condition) with high accuracy, low scanner cost, and a dose comparable to that of a conventional CT scan. The patients will therefore receive a lower radiation dose with an improved diagnostic, and the population of patients that can be imaged will be widened.

描述（由申请人提供）：我们对冠状动脉的X射线计算机断层扫描（CT）成像感兴趣，通常称为冠状动脉CT血管造影（CTA）。具体而言，我们建议一种创新的低成本解决方案，以解决单个心跳中精确的冠状动脉CTA的问题。该解决方案是将图像重建理论中最新进展与仔细的系统设计注意事项相结合的结果。更具体地说，我们建议减轻整个心脏的圆形CB层析成像发生的伪像，使用（i）使用（i）一种新的扫描概念，称为交错的圆形扫描，该概念使用多个X射线源一起获得平行圆形轨迹的CB数据，以降低圆锥体的净效果，而不需要在不需要的轴向运动中降低（II）轴向运动，II）轴向运动，ii）轴向运动，II）理论。交错的圆形扫描用索引K定义，该索引K给出了涉及的X射线源数量。我们将精力集中在以下目的上：（1）使用索引k = 2，k = 3和k = 4的交错圆形扫描使用交错的圆形扫描，开发，实施和验证对准确的冠状动脉CTA进行开发，实施和验证。（3）实际数据的鲁棒性演示。（4）使用扫描仪进行扫描仪进行交错的圆形扫描的扫描仪的可行性证明准确的总体成像。公共卫生相关性：叙事该提案旨在允许技术飞跃，以便以高准确性，低扫描仪的成本和与常规CT扫描相当的剂量来始终如一地（即独立于患者的心脏状况）来实现心脏CT成像。因此，患者将接受较低的辐射剂量，并有改善的诊断剂量，并且可以扩大可以成像的患者人群。