RESTORATION OF HAND AND ARM FUNCTION BY FNS

FNS 恢复手部和手臂功能

• 批准号: 7950355
• 负责人: Robert F. Kirsch
• 金额: $ 70.04万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950355
• 关键词: RESTORATION; HAND; ARM; FUNCTION; FNS

We will deploy 4 new upper extremity neuroprostheses covering all elvels of cervical level spinal cord injuries (SCI) with sufficient numbers of subjects to provide support for larger clinical trials in the future. All of these neuroprostheses will use implanted stimulators and 3 of 4 2ill use implanted EMG recording modules. EMG-based control algorithms will provide fully implanted coman and control interfaces while exploiting the subjects' retained voluntary function. Both stimulation and recording odules will be commercially manufactured, greatly facilitating their eventual deployment in to the general clinical environment. This project will also push the frontiers of neuroprostheses in several significant ways. In collaboration with a parallel effort funded by NICHD, we will work to more "brain achine interfaces" into use as a neuroprosthesis command interface for individuals with high cervical spinal cord injusries. We will also examine the potential of useing the Flat Interface Nerve Interface (FINE) to activvate multiple muscles from as proximal a location as possible, potentially leading to a nerve electrode-only implementation with a lower surgical impact. Finally, we will examine the use of the FINE as an interface for recording from cutaneous enrve fascicles arising in the hand as a source of information for providing electrocutaneous feedback regarding the state of the hand.

我们将部署4种新型上肢神经假体，覆盖颈椎脊髓损伤（SCI）的各个层面，并有足够数量的受试者，为未来更大规模的临床试验提供支持。 所有这些神经假体都将使用植入式刺激器，其中 4 2 个中的 3 个将使用植入式肌电图记录模块。 基于肌电图的控制算法将提供完全植入的科曼和控制界面，同时利用受试者保留的自愿功能。 刺激和记录模块都将进行商业化生产，这极大地促进了它们最终部署到一般临床环境中。 该项目还将在几个重要方面推动神经假体的前沿发展。 我们将与 NICHD 资助的一项并行工作合作，致力于将更多的“脑机接口”用作高位颈髓损伤患者的神经假体命令接口。 我们还将研究使用平面神经接口 (FINE) 从尽可能近的位置激活多块肌肉的潜力，从而可能导致仅使用神经电极实现手术影响较小的情况。 最后，我们将检查 FINE 作为记录手部皮肤神经束的界面的使用，作为提供有关手部状态的皮肤电反馈的信息源。