RR&D Research Career Scientist Application

RR

• 批准号: 10536800
• 负责人: Robert F. Kirsch
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10536800
• 关键词: Academia; Activities of Daily Living; Address; Algorithms; American; Amputees; Anatomy; Area; Artificial Intelligence; Biomedical Engineering; Brain; Caring; Cervical; Cervical spinal cord injury; Characteristics; Clinical; Communities; Custom; Development; Doctor of Philosophy; Education; Elbow; Electrodes; Engineering; Faculty; Funding; Hand; Health; Healthcare; Human; Human Resources; Incidence; Individual; Injury; Institutes; Intervention; Intuition; Journals; K-Series Research Career Programs; Laboratories; Leadership; Learning; Medical; Mentors; Methods; Military Personnel; Modeling; Movement; Muscle; Muscle Contraction; Muscle function; Musculoskeletal; Neck; Nerve; Orthotic Devices; Pain; Paralysed; Participant; Pattern; Persons; Population; Prosthesis; Proxy; Psychological reinforcement; Publications; Quadriplegia; Rehabilitation therapy; Research; Research Activity; Research Personnel; Research Project Grants; Role; Scientist; Seminal; Series; Services; Shoulder; Signal Transduction; Skeletal Muscle; Spinal Cord; Spinal cord injury; Study Section; System; Techniques; Training; Translational Research; Translations; United States; United States National Institutes of Health; Universities; Upper Extremity; Upper limb movement; Veterans; Volition; Work; arm; arm movement; brain computer interface; brain health; career; combat injury; design; disability; first-in-human; functional electrical stimulation; improved; member; nervous system disorder; neural implant; neural network; neuroregulation; neurorestoration; neurotechnology; novel; programs; prosthesis control; rehabilitation research; relating to nervous system; research and development; restoration; simulation; symposium; translational research program; undergraduate student

Dr. Kirsch has been a VA RR&D research for 28 years, and a VA RR&D Research Career Scientist since 2007. He has a very active research program and is a leader in both rehabilitation research and academia. His personal research activities focus on restoring shoulder, arm, and hand movements to individuals with extensive paralysis due to spinal cord injury (SCI). SCI is a devastating condition that often causes significant disability and loss of independence. Veterans are historically over-represented in the SCI population, and the incidence of SCI in more recent military engagements remains high. As a result, the VA Rehabilitation Research and Development Service has prioritized SCI research, and Dr. Kirsch’s research directly aligns with this priority. His research specifically focuses on restoring arm/hand movement to individuals with high cervical (C1-C4) SCI, a condition referred to as high tetraplegia, who have extensive paralysis below the neck. Such individuals are typically dependent on others for most aspects of care and activities of daily living. Dr. Kirsch has developed state-of-the-art (1) functional electrical stimulation (FES) systems for powering and coordinating arm and hand movements in people with high tetraplegia, (2) human brain-computer interfaces that allow users to intuitively command FES-powered arm movements, and (3) musculoskeletal models of the human shoulder and elbow that are modified to reflect the specific characteristics of individuals with SCI or other disabilities, and then used in simulation to explore the feasibility of an intervention (e.g., FES) and to optimize system design for clinical deployment, substantially decreasing experimental trial-and-error. Dr. Kirsch’s research work is well-funded, his publication record over the past five years has been very strong (quality and quantity), and he is a sought-after speaker for seminars and conferences. Dr. Kirsch has also undertaken a number of leadership roles in rehabilitation research. He has been the Executive Director of the VA RR&D-supported FES Center since January 2012. The FES Center is a global leader in neurostimulation/neuromodulation research that addresses the unmet rehabilitation needs of Veterans and civilians with neurological disorders. Specifically, the FES Center has 86 investigators (43 scientists/engineers and 43 clinicians) and almost 200 total personnel who perform and facilitate cutting edge research across 5 different rehabilitation research thrusts: (1) Movement Restoration, (2) Pain Mitigation, (3) Autonomic Restoration, (4) Brain Health, and (5) Translation and Clinical Dissemination. In addition, Dr. Kirsch is a leader in translational research, being a co-PI of the of a new VA center entitled the “VA Translational Education and Mentoring (VA-TEAM) Center” that is focused on educating and mentoring the VA’s most promising translational research projects across the US., as well as the PI of the Case-Coulter Translational Research Partnership, a nationally prominent program at Case Western Reserve University. Dr. Kirsch is very active in the national research and academic communities. He was a member of the VA RR&D Career Development Award panel for 10 years and was its Chair for 5 years. He has served on review panels for VA RR&D center applications, Research Career Scientist review panels, two standing NIH study sections, and more than 50 proposal review panels overall. He served as the host for the 2017 VA RR&D National Center/REAP Directors’ Retreat. He serves on 12 advisory or review boards for academic departments and research centers. Dr. Kirsch has been the Chair of Biomedical Engineering at Case Western Reserve University for 10 years. He served as Vice Chair (2016), Chair (2017), and Immediate Past Chair (2018) of the national Biomedical Engineering Council of Chairs, and was the host of the national Council of Chairs Educational Summit in 2019. He is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). He is a prolific mentor, having trained 17 PhD graduates and mentored large numbers of undergraduate students, young investigators, and faculty at several levels.

Kirsch 博士在 VA RR&D 从事研究工作已有 28 年，自 2017 年起担任 VA RR&D 研究职业科学家 2007 年。他有一个非常活跃的研究项目，是康复研究和学术界的领导者。 个人研究活动的重点是恢复患有以下疾病的人的肩部、手臂和手部运动 脊髓损伤 (SCI) 导致的大范围瘫痪是一种毁灭性的疾病，通常会导致严重的后果。 历史上，残疾和丧失独立性的退伍军人在 SCI 人群中所占比例过高。 最近的军事行动中脊髓损伤的发生率仍然很高，因此退伍军人管理局康复中心。 研发服务优先考虑 SCI 研究，Kirsch 博士的研究直接与 他的研究重点是恢复高颈椎患者的手臂/手部运动。 (C1-C4) SCI，一种称为高位四肢瘫痪的病症，表现为颈部以下广泛瘫痪。 基尔希博士表示，个人在大部分护理和日常生活活动方面通常依赖他人。 开发了最先进的 (1) 功能性电刺激 (FES) 系统，用于供电和协调 高位四肢瘫痪患者的手臂和手部运动，（2）允许用户的人脑机接口 直观地控制 FES 驱动的手臂运动，以及 (3) 人体肩部的肌肉骨骼模型 和肘部经过修改以反映 SCI 或其他残障人士的具体特征， 然后用于模拟，探索干预措施（例如 FES）的可行性并优化系统 临床部署的设计，大大减少了 Kirsch 博士的研究工作。 资金充足，过去五年的出版记录非常出色（质量和数量），并且 他是研讨会和会议上广受欢迎的演讲者。 Kirsch 博士还在康复研究领域担任过多项领导职务。 自 2012 年 1 月起担任 VA RR&D 支持的 FES 中心执行董事。FES 中心是一个全球性中心 神经刺激/神经调节研究的领导者，解决未满足的康复需求 具体而言，FES 中心有 86 名调查员（43 名患有神经系统疾病的退伍军人和平民）。 科学家/工程师以及近 200 名执行和促进尖端技术的人员 跨越 5 个不同康复研究方向的研究：(1) 运动恢复，(2) 减轻疼痛，(3) 自主恢复，(4) 大脑健康，以及 (5) 翻译和临床传播 此外，Kirsch 博士。 是转化研究领域的领导者，是名为“VA Translational”的新 VA 中心的联合 PI 教育和指导 (VA-TEAM) 中心”，专注于教育和指导 VA 最优秀的人才 美国各地有前景的转化研究项目，以及 Case-Coulter Translational 的 PI 研究合作伙伴关系是凯斯西储大学全国知名的项目。 基尔希博士在国家研究和学术界非常活跃，他是该组织的成员。 他曾担任 VA RR&D 职业发展奖小组 10 年，并担任主席 5 年。 VA RR&D 中心申请审查小组、研究职业科学家审查小组、两个常设 NIH 他担任 2017 年 VA RR&D 的主持人。 他在 12 个学术顾问或审查委员会任职。 Kirsch 博士曾担任 Case Western 生物医学工程系主任。 他曾担任预备大学副主席（2016 年）、主席（2017 年）和上任主席。 (2018) 全国生物医学工程委员会主席，并主办全国生物医学工程委员会 主持 2019 年教育峰会。他是美国医学和生物研究所院士 他是一位多产的导师，培养了 17 名博士毕业生并指导了大量的人。 本科生、年轻研究人员和多个级别的教师。