Center for Functional Electrical Stimulation

功能性电刺激中心

• 批准号: 10043833
• 负责人: Robert F. Kirsch
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10043833
• 关键词: Area; Autonomic nervous system; Bladder; Brain; Caring; Clinical; Collaborations; Communication; Communities; Core Facility; Desire for food; Development; Disease; Economics; Effectiveness; Electric Stimulation; Electrodes; Engineering; Environment; Epilepsy; Evolution; Foundations; Funding; Future; General Population; Goals; Growth; Hypertension; Industrialization; Inflammation; Infrastructure; Injury; Intervention; Intestines; Knowledge; Leadership; Limb structure; Medical Illustration; Mental disorders; Modeling; Movement; Movement Disorders; Nervous System Trauma; Nervous system structure; Neurologic; Neurons; Neurophysiology - biologic function; Pain; Parkinson Disease; Patients; Peripheral Nerve Stimulation; Productivity; Regulation; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Scientist; Services; Spinal Cord; Spinal cord injury; Stroke; Structure; System; Techniques; Technology; Traumatic Brain Injury; Veterans; Visceral; base; brain health; career development; chronic pain; community building; disability; effective therapy; functional electrical stimulation; innovation; inter-institutional; models and simulation; nervous system disorder; neuropsychiatric disorder; novel strategies; rehabilitation research; research and development; respiratory; restoration; success; tool; tool development

The Center for Functional Electrical Stimulation (FES Center) is a 25 year consortium that develops and deploys rehabilitation treatments based on functional electrical stimulation (FES) for Veterans and civilians with neurological, autonomic, psychiatric, pain, and other disorders. The VISION of the Cleveland FES Center is broad - to perform cutting edge research and creative engineering, and to then transition these discoveries and technologies into the clinical environment to create effective, clinically-available options for patients and the people who care for them. The MISSION of the FES Center, however, is very clear and tightly focused - to develop interventions based on the electrical stimulation of the nervous system to replace or compensate for natural neural function lost due to neurological disease or injury. The scope of FES Center research has evolved and expanded significantly during the current five year funding cycle to reflect new scientific discoveries and new clinical opportunities. This proposal represents this evolution and thus describes the five research thrusts of the FES Center for the next five years: (1) MOVEMENT RESTORATION: restoring limb, respiratory, and other body movements; (2) BRAIN HEALTH: brain stimulation interventions for movement disorders (e.g., Parkinson's disease), stroke and traumatic brain injuries, epilepsy, and neuropsychiatric disorders, as well as brain recording technologies; (3) PAIN: pain mitigation through stimulation of peripheral nerves and the spinal cord; (4) AUTONOMIC SYSTEMS: autonomic nervous system stimulation for restoration and/or regulation of internal body and visceral functions; and (5) TECHNOLOGY AND TOOLS: development of basic stimulation techniques, implantable systems and electrodes, modeling and simulation tools, and other rehabilitation approaches complementary to FES. These seemingly diverse research thrusts in fact share a deep foundation of basic knowledge, use similar and often identical technologies, and rely on a proven model of genuine clinical-technical partnerships. The FES Center has built a critical mass of investigators in each of these research thrust areas, and will continue to pursue research in important new clinical areas where FES may provide effective treatments. FES Center research thrusts are tightly aligned with the priorities of the VA RR&D Service, and FES Center investigators are leaders in the national and local rehabilitation communities. The FES Center operates with core funding from the VA Rehabilitation Research and Development Service and uses these resources to broadly enable the success of its investigators by providing a unique technical infrastructure, specialized research services (regulatory, statistical, medical illustration, inter-institutional administrative support), development of key industrial and academic relationships, and communication to potential patients, other scientists, and to the general public. The consortium structure of the FES Center continues to effectively leverage the amazingly rich academic and clinical expertise across the Cleveland area. The FES Center focus on community building, collaboration and inclusion, and shared infrastructure – rather than on funding specific projects – has promoted continuous innovation and growth, enabled MANY investigators to successfully pursue major projects that would otherwise be impractical, and has realized economic efficiencies through core facilities and economies of scale. AND, the FES Center has steered this major enterprise to focus on the rehabilitation challenges of Veterans! The FES Center and its investigators have been highly successful over the past five years in terms of research productivity and collaboration, clinical impact, leadership in rehabilitation research, and training and career development of VA investigators. We have developed ambitious but obtainable goals for the coming 5 years, as well as a clear plan for achieving these goals. The FES Center will continue to provide core resources that can be leveraged by our investigators and their interdisciplinary teams to conduct unique, cutting-edge research and clinical deployment. The scope of FES Center research has been expanded over the past five years, but our overriding objective - to achieve increasingly meaningful impact on the lives of Veterans and civilians with disabilities - remains unchanged. The FES Center is thus poised to have continued impact on rehabilitation research into the future.

功能性电刺激中心（FES 中心）是一个拥有 25 年历史的联盟，致力于开发和部署 为退伍军人和患有神经系统疾病的平民提供基于功能性电刺激 (FES) 的康复治疗 克利夫兰 FES 中心的愿景是广泛的 - 执行。 尖端研究和创意工程，然后将这些发现和技术转化为 临床环境，为患者及其护理人员创造有效的、临床可用的选择。 然而，FES 中心的使命非常明确且重点突出 - 根据以下情况制定干预措施： 对神经系统进行电刺激，以替代或补偿因自然神经功能丧失而丧失的功能 FES 中心的研究范围在神经疾病或损伤期间发生了显着的变化。 当前的五年资助周期反映了新的科学发现和新的临床机会。 代表了这种演变，从而描述了 FES 中心未来五年的五个研究重点：(1) 运动恢复：恢复肢体、呼吸和其他身体运动； (2) 大脑健康：大脑 针对运动障碍（例如帕金森病）、中风和创伤性脑损伤的刺激干预措施， (3) PAIN：通过以下方式缓解疼痛 (4) 自主系统：自主神经系统 用于恢复和/或调节内部身体和内脏功能的刺激；以及 (5) 技术和 工具：开发基本刺激技术、植入系统和电极、建模和模拟 事实上，这些看似不同的研究主旨。 共享深厚的基础知识，使用相似且通常相同的技术，并依赖经过验证的技术 FES 中心在每个领域都建立了足够数量的研究人员。 这些研究重点领域，并将继续在 FES 可能的重要新临床领域进行研究 FES 中心的研究重点与 VA RR&D 的优先事项紧密结合。 服务中心和 FES 中心的调查员是国家和地方康复社区的领导者。 FES 中心的运营核心资金来自 VA 康复研究与开发服务 利用这些资源，通过提供独特的技术基础设施，广泛地帮助其调查人员取得成功， 专业研究服务（监管、统计、医学插图、机构间行政支持）， 发展关键的工业和学术关系，以及与潜在患者、其他科学家的沟通， FES 中心的联盟结构继续有效地利用 FES 中心在克利夫兰地区拥有令人惊叹的丰富学术和临床专业知识，专注于社区。 建设、协作和包容以及共享基础设施——而不是资助特定项目—— 促进持续创新和发展，使许多研究人员能够成功开展重大项目 否则是不切实际的，并且通过核心设施和经济实现了经济效率 而且，FES 中心引导这家大型企业专注于退伍军人的康复挑战！ FES 中心及其研究人员在过去五年中在研究方面取得了巨大成功 生产力和协作、临床影响、康复研究领导力以及培训和职业 我们还为未来 5 年制定了雄心勃勃但可实现的目标。 作为实现这些目标的明确计划，FES 中心将继续提供可用于的核心资源。 我们的研究人员及其跨学科团队利用这些数据进行独特的前沿研究和临床 过去五年来，FES 中心的研究范围不断扩大，但我们的首要任务是。 目标 - 对退伍军人和残疾平民的生活产生越来越有意义的影响 - 仍然存在 因此，FES 中心将继续对未来的康复研究产生影响。