Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis

规模感：使用混合规模系统进行稀有生物标志物分析

• 批准号: 10693396
• 负责人: Steven Allan Soper
• 金额: $ 12.99万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-16 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693396
• 关键词: Affect; Area; Biological; Biological Markers; Biological Process; Biology; Biomedical Engineering; Biopsy Specimen; Biotechnology; Cell Size; Cells; Characteristics; Clinical; Clinical Research; Clinical Treatment; Collaborations; Communities; Competence; Core Biopsy; Core Facility; DNA; Detection; Devices; Diagnosis; Diffusion; Disease; Disease Management; Education; Educational workshop; Entrepreneurship; Environment; Event; Facebook; General Population; Generations; Healthcare; Institution; Instruction; International; Investigation; Label; Laboratories; Legal patent; Length; Link; Medical; MicroRNAs; Microfluidics; Miniaturization; Mission; Modeling; Molecular; Nanotechnology; Output; Participant; Patient Care; Patient-Focused Outcomes; Patients; Peer Review; Physicians; Process; Proteins; Publications; Reaction; Recruitment Activity; Research; Research Personnel; Resources; Role; Route; Sampling; Scholars Program; Secure; Series; Services; Site; Source; Students; System; Technology; Training; Training Activity; Training Programs; Translating; Translational Research; Treatment Protocols; Twitter; base; bench to bedside; biological systems; commercialization; design; experience; experimental study; fabrication; improved; in-vitro diagnostics; individualized medicine; industry partner; innovation; innovative technologies; interest; lectures; liquid biopsy; meetings; member; meter; molecular marker; nanofabrication; nanofluidic; nanometer; nanoscale; new technology; news; precision medicine; program dissemination; single molecule; skills; social; social media; stem; technology research and development; tool; treatment strategy; visiting scholar; web page; web site; webinar

TITLE: Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine Training and Dissemination: Sense-of-Scale: The use of mixed-scale systems for rare biomarker analysis Abstract/Summary The Center of BioModular Multi-Scale Systems for Precision Medicine (CBM2) seeks to develop innovative mixed-scale tools for the analysis of liquid biopsy markers that aid in managing patients' diseases by identifying appropriate clinical treatment strategies that benefit patients guided by the molecular composition of their disease. This approach, known as ”Precision Medicine,” will be the focus of the Center's Training and Dissemination (T&D) efforts by leveraging the compelling research taking place under the umbrella of the Center's Technology Research and Development (TR&D) projects. The Center will participate in training and educating patrons (i.e., non-Center affiliated researchers, collaborators, students, physicians, and potential industry partners) on Center technologies, “How to Make It”, and “How to Use It.” Findings and discoveries stemming from the TR&Ds will be efficiently disseminated into the scientific community and to physicians involved in clinical research. CBM2 will take advantage of existing resources within the Center's affiliated institutions (KU, UNC, and LSU) to familiarize the biomedical community with its extensive capabilities; an example includes state-of-the-art nanofabrication resources located at all three campuses. Dissemination of Center discoveries will be enhanced by compelling publications, patents, and the formation of startups around Center IP. The Center will educate a non-scientific community on the subject of Precision Medicine and the benefits it offers in terms of the improvement of patient care and disease management. Dissemination will follow traditional routes and those not so traditional, such as publications and presentations at national/international meetings as well as a robust website, social media, and online instructional videos. Our visiting scholar program to engage non-affiliated researchers in the Center's TR&D projects will facilitate dissemination. The common theme of the Center's T&D efforts will be, “Sense-of-Scale: the use of mixed-scale systems for rare biomarker analysis”. CBM2's objectives in training will be to convey the message that biological systems (i.e., liquid biopsy markers such as cfDNA, miRNA, proteins, EVs, and cells) span many sizes and that biotechnology research frequently involves experiments that must link different biological length scales together to realize the delivery of effective integrated systems for their analysis. Training efforts will involve discussions on defining research areas based on the characteristic size of the biological system of interest and time-scales of relevant phenomena (i.e., reactions, separations, diffusion) under investigation. T&D events will seek to answer questions related to differences between processes that take place in a micro- and nano-scale environment. How does biology differ when executed below tens of micrometers or nanometers? Can these processes be modeled? How can observables in different length scales be used for designing fluidic systems with different sizes? Hands- on experiments will be designed that will convey to parties the size of cells, EVs, and DNA and how devices can be developed to analyze them.

标题：精准医学生物模块化多尺度系统（CBM2）生物技术资源中心 培训和传播：规模感：使用混合规模系统进行稀有生物标志物分析 摘要/总结 精准医学生物模块化多尺度系统中心 (CBM2) 致力于开发创新型 用于分析液体活检标记物的混合规模工具，通过识别来帮助管理患者的疾病 根据患者的分子组成指导，制定有利于患者的适当的临床治疗策略 这种被称为“精准医学”的方法将成为该中心培训和治疗的重点。 通过利用在该框架下进行的引人注目的研究来进行传播（T&D）工作 中心的技术研究与开发（TR&D）项目 该中心将参与培训和开发。 教育赞助人（即非中心附属研究人员、合作者、学生、医生和潜在的 行业合作伙伴）介绍中心技术、“如何制造它”和“如何使用它”。 TR&D 产生的成果将有效地传播到科学界和医生中 CBM2将利用中心附属机构内的现有资源参与临床研究。 机构（KU、UNC 和 LSU）让生物医学界熟悉其广泛的能力； 示例包括位于所有三个校区的最先进的纳米制造资源。 中心的发现将通过引人注目的出版物、专利和初创企业的组建而得到加强 中心 IP。该中心将为非科学界提供有关精准医学和精准医学主题的教育。 它在改善患者护理和疾病管理方面带来的好处将随之而来。 传统途径和非传统途径，例如在国家/国际上的出版物和演讲 会议以及强大的网站、社交媒体和在线教学视频。 让非附属研究人员参与该中心的 TR&D 项目将有助于传播。 该中心 T&D 工作的共同主题是“规模感：使用混合规模系统来研究稀有的 CBM2 的培训目标是传达生物系统（即， 液体活检标记物（例如 cfDNA、miRNA、蛋白质、EV 和细胞）涵盖多种尺寸，并且生物技术 研究经常涉及必须将不同生物长度尺度连接在一起的实验，以实现 提供有效的综合系统进行分析 培训工作将涉及关于定义的讨论。 基于感兴趣的生物系统的特征规模和相关的时间尺度的研究领域 T&D 事件将寻求回答问题。 与微米级和纳米级环境中发生的过程之间的差异有关。 当在几十微米或纳米以下执行时，生物学会有所不同吗？这些过程可以建模吗？ 如何使用不同长度尺度的可观测量来设计不同尺寸的流体系统？ 将设计一系列实验，向各方传达细胞、EV 和 DNA 的大小以及设备如何 被开发来分析它们。