8th Global Symposium on Ketogenic Therapies

第八届全球生酮疗法研讨会

基本信息

批准号：
10753748
负责人：
Jong Min Rho
金额：
$ 2.5万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10753748
关键词：
Adult Advocacy Alzheimer&apos s Disease Anniversary Anticonvulsants Anxiety Awareness Basic Science Bipolar Disorder Brain Budgets California Carbohydrates Clinical Clinical Investigator Clinical Research Cognition Disorders Collaborations Communities Congresses Country Dedications Diet and Nutrition Diet therapy Dietitian Discipline Disease Dissemination and Implementation Eastern Africa Eastern Europe Education Educational workshop Effectiveness Eligibility Determination Epilepsy Fasting Fatty Acids Fatty acid glycerol esters Fellowship Fertilization Formulation Foundations Funding Future Generations Glucose Transporter Goals Grant Growth Headache International Intractable Epilepsy Ketone Bodies Knowledge Lead Malignant - descriptor Malignant neoplasm of brain Mediator Medical Mental Depression Mental Health Mental disorders Metabolic Metabolism Modernization Multiple Sclerosis Neurologic Nurses Parkinson Disease Patients Perception Physicians Postdoctoral Fellow Pre-Clinical Model Professional Organizations Property Proteins Protocols documentation Randomized Recording of previous events Research Research Personnel Resources SLC2A1 gene Schedule Schizophrenia Science Scientist Series Sleep Disorders Social Workers Societies Solid Southeastern Asia Standardization Students Syndrome Therapeutic Time Training Translational Research Travel United States National Institutes of Health Variant autism spectrum disorder brain metabolism chronic pain clinical application clinical efficacy dietary equity, diversity, and inclusion experience health application innovation interdisciplinary collaboration interest ketogenic diet ketogentic meetings neglect nervous system disorder neuroprotection novel personalized care posters pre-clinical programs prospective spinal cord and brain injury success symposium treatment choice

项目摘要

PROJECT SUMMARY The ketogenic diet (KD) is an established medical therapy for drug-resistant epilepsy, and since its origins in 1921 has steadily grown in clinical importance and worldwide implementation. Moreover, the expanding research into the scientific underpinnings of this metabolism-based treatment have highlighted numerous novel mechanisms. Moreover, there is mounting experimental evidence for potential disease-modifying and neuroprotective properties of metabolic substrates such as ketone bodies and fatty acids, such that preclinical and clinical investigators have been exploring broader uses of the KD and its variants in diverse neurological (and even mental health) conditions such as malignant brain cancer, autism spectrum disorder, Alzheimer's disease, and bipolar disorder. Despite proven clinical efficacy and relative affordability compared to anti-seizure medications, large regions of the world still do not and cannot broadly offer KD therapies to eligible patients. Centers often have inadequate resources, as well as a lack of appropriately trained physicians and/or dietitians. Furthermore, the latest research findings may not be well disseminated, and a lack of standardized protocols and management strategies present additional barriers. Without adequate support or proper education, patients may not consider this treatment due to its traditional restrictiveness and myths surrounding its use. Regular regional and international meetings are needed where scientists, physicians, dietitians, nurses, social workers and trainees at all levels can meet and discuss and share protocols, research innovations, clinical experience and establish new collaborations in the growing KD field. The 8th Global Symposium on Ketogenic Therapies (to be held September 17-21, 2023 in San Diego, California) is the latest in a successful and evolving biennial conference series first launched in 2008 with support from a NIH R13 conference grant. There has been an enduring collaborative spirit with a common purpose that has now matured into a new professional society called the International Neurological Ketogenic Society or INKS. The 8th Global Symposium represents another leap forward: the focus remains on promoting collaborative interactions among clinical and basic scientists and trainees and disseminating the latest research to the community and beyond, and a strong emphasis will be placed on standardizing and enhancing international dissemination and implementation – all of this in the spirit of equity, diversity and inclusion. Moreover, this will be the first congress in the biennial series organized in conjunction with two aligned organizations, the Glucose Transporter Deficiency 1 (GLUT1) Foundation and the International Society of Neurogastronomy (ISN). The KD is the treatment of choice for the GLUT1 deficiency syndrome, and ISN's focus on the science and practice of flavor perception represents an often-neglected aspect of diet and nutrition that is central to compliance and success of dietary treatments. These symposia will remain the definitive venue for progress in and advocacy for metabolism-based therapies for neurological disorders.

项目概要生酮饮食（KD）是一种针对耐药性癫痫的成熟医学疗法，自其起源于 1921 的临床重要性和全球实施范围不断扩大，研究不断扩大。这种基于新陈代谢的治疗的科学基础已引起众多小说的关注此外，越来越多的实验证据表明潜在的疾病缓解和治疗作用。代谢底物（例如酮体和脂肪酸）的神经保护特性，使得临床前临床研究人员一直在探索 KD 及其变体在不同神经系统疾病中的更广泛用途（甚至心理健康）疾病，如恶性脑癌、自闭症谱系障碍、阿尔茨海默氏症尽管与抗癫痫药物相比，临床疗效和相对负担能力已得到证实。药物治疗，世界上大部分地区仍然没有也不能向符合条件的患者广泛提供生酮饮食疗法。中心往往资源不足，并且缺乏经过适当培训的医生和/或营养师。此外，最新的研究成果可能没有得到很好的传播，并且缺乏标准化的协议如果没有足够的支持或适当的教育，患者和管理策略会带来额外的障碍。由于其传统的限制性和围绕其使用的神话，可能不会考虑这种治疗。需要召开区域和国际会议，由科学家、医生、营养师、护士、社会工作者参加各级学员可以见面、讨论和分享方案、研究创新、临床经验并在不断发展的 KD 领域建立新的合作第八届全球生酮疗法研讨会（至将于 2023 年 9 月 17 日至 21 日在加利福尼亚州圣地亚哥举行）是成功且不断发展的双年展中的最新一届会议系列于 2008 年首次启动，得到了 NIH R13 会议拨款的支持。具有共同目标的持久协作精神，现已成熟为一个新的专业协会，称为国际神经生酮学会（INKS）代表着第八届全球研讨会的又一次飞跃。前进：重点仍然是促进临床和基础科学家之间的协作互动和学员，并向社区内外传播最新研究成果，并高度重视将致力于标准化和加强国际传播和实施——所有这一切此外，本着公平、多样性和包容性的精神，这将是两年一度的系列会议的第一次。与两个联盟组织联合组织：葡萄糖转运蛋白缺乏症 1 (GLUT1) KD 是该病的首选治疗方法。 GLUT1 缺乏综合症，ISN 对风味感知的科学和实践的关注代表了饮食和营养中经常被忽视的方面，对于饮食治疗的依从性和成功至关重要。研讨会仍将是促进基于代谢的疗法的进展和倡导的最终场所神经系统疾病。