International Symposium on Dietary Therapies for Epilepsy and Other Neurological

癫痫及其他神经疾病饮食治疗国际研讨会

基本信息

批准号：
7485255
负责人：
Jong Min Rho
金额：
$ 1万
依托单位：
ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7485255
关键词：
Accounting Adult Adverse effects Ally Alzheimer&apos s Disease Amyotrophic Lateral Sclerosis Anticonvulsants Area Basic Science Biochemical Brain Brain Neoplasms Caloric Restriction Carbohydrates Childhood Clinical Clinical Research Collaborations Condition Diet Dietary Factors Dietary Intervention Dietitian Disease Epilepsy Fasting Fatty acid glycerol esters Future Goals Growth Health Professional International Intervention Medical Surveillance Medical center Medicine Metabolic Molecular Nerve Degeneration Neurologic Neurologist Nurses Other Therapy Parkinson Disease Patients Pharmaceutical Preparations Pharmacotherapy Process Public Health Refractory Research Research Personnel Scientist Seizures Spinal cord injury Time United States Variant clinical effect day experience improved interest ketogenic diet multidisciplinary neglect nervous system disorder novel posters symposium

项目摘要

DESCRIPTION (provided by applicant): While most neurological disorders have traditionally been treated with pharmacological agents, there is growing evidence that dietary interventions can also exert beneficial clinical effects comparable to, or perhaps exceeding, drug therapy. This is especially true for the epilepsies which respond favorably to a high-fat low-carbohydrate diet known as the ketogenic diet. Indeed, following historical observations that fasting was effective for seizure control, clinicians formulated the ketogenic diet in the 1920's to mirror the biochemical changes seen in the fasted state. And although the ketogenic diet has been available since then in medical centers throughout the United States, it was not until this past decade that widespread international acceptance of this non-pharmacological intervention as an effective treatment for medically refractory epilepsy had been achieved. Scientific interest in the ketogenic diet has also paralleled the growth of clinical centers throughout the world, with the goal of understanding its underlying mechanisms of action - important information that is necessary to improve upon its clinical implementation. In the past several years, variations of the ketogenic diet have emerged as efficacious and better tolerated options in the treatment of epilepsy in both pediatric and adult patients. Additionally, there is a small but growing interest in treating other neurological disorders with dietary interventions - such as calorie restriction - that share some biochemical similarities with the KD. These conditions include Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, traumatic brain & spinal cord injury, and even brain tumors. That dietary factors should influence brain function is not altogether surprising, but it is important to note that such treatments can exert such profound clinical effects, where in many instances drugs have failed to produce lasting effects. A greater fundamental understanding of dietary and metabolic effects of brain function and disease processes is required to develop novel and effective strategies for what are often considered neurodegenerative and/or debilitating disorders. This symposium is aimed at neurologists, epileptologists, research scientists, nurses, dietitians, and other allied health professionals, with the fundamental goal of sharing up-to-date information on this rapidly expanding topic, and defining the important clinical and research questions that should be pursued in the future. Additionally, this symposium will provide a forum for extended discussions regarding practical clinical implementation, surveillance of adverse effects, and importantly, a critical look at basic cellular and molecular mechanisms that could account for the anticonvulsant and neuroprotective effects of the ketogenic diet. This symposium will be held over three full days, and will consist of both plenary sessions and mini- symposia, as well as poster and break-out sessions devoted to specific groups of healthcare professionals and researchers. While much of the focus of the symposium will be on dietary treatments for epilepsy, the final day will review our clinical and experimental experience with dietary therapies for other neurological disorders (including Alzheimer's and Parkinson's diseases, brain tumors and neurotrauma), paving the way toward a greater understanding of how dietary substrates, and the biochemical and metabolic consequences of their administration, can protect the diseased brain. An additional practical short-term goal will be to have attendees share information and establish clinical and research collaborations. It takes a multidisciplinary team to successfully implement the ketogenic diet, study it appropriately, and improve upon it. This spirit of cooperation constitutes the core rationale for this international symposium. PUBLIC HEALTH RELEVANCE: The fundamental goal of this symposium is to share up-to-date information on the rapidly expanding topic of dietary therapies for epilepsy, and to define the important clinical and research questions that should be pursued in the future. While there have been a few international meetings devoted to the topic of the KD, none have comprehensively examined both clinical and basic science aspects of this time-honored treatment. As such, we believe that this symposium may be the first landmark scientific meeting devoted to this long-neglected area of medicine.

描述（由申请人提供）：虽然传统上用药理学药物治疗了大多数神经系统疾病，但越来越多的证据表明，饮食干预措施也可以发挥有益的临床作用，可与药物治疗相当或超过药物治疗。对于对高脂低碳水化合物饮食的反应良好的癫痫尤其如此，称为生酮饮食。确实，在历史观察中，禁食对癫痫发作有效，临床医生在1920年代制定了生酮饮食，以反映禁食状态下的生化变化。尽管自那时以来，在美国的医疗中心就可以使用生酮饮食，但直到过去十年才广泛接受这种非药理学干预措施，作为对医学难治性癫痫的有效治疗方法。生酮饮食中的科学兴趣也与世界各地的临床中心的增长相似，目的是了解其潜在的作用机制 - 重要的信息是改善其临床实施所必需的重要信息。在过去的几年中，生酮饮食的变化已成为小儿和成人患者癫痫治疗癫痫的有效和耐受性。此外，对使用饮食干预（例如卡路里限制）治疗其他神经系统疾病的兴趣越来越小，与KD具有某些生化相似性。这些疾病包括帕金森氏病，阿尔茨海默氏病，肌萎缩性侧索硬化症，脑外伤和脊髓损伤，甚至是脑肿瘤。饮食因素应影响大脑功能并不是完全令人惊讶的，但是重要的是要注意，这种治疗方法可以发挥如此深刻的临床影响，在许多情况下，药物未能产生持久的作用。需要对脑功能和疾病过程的饮食和代谢作用有更大的基本了解，以制定新颖有效的策略，以针对通常被认为是神经退行性和/或使人衰弱的疾病。该研讨会针对神经科医生，癫痫学家，研究科学家，护士，营养师和其他相关卫生专业人员，其基本目标是分享有关这个快速扩展的主题的最新信息，并定义了将来应该提出的重要临床和研究问题。此外，该研讨会将为有关实际临床实施，不良反应监视的扩展讨论提供一个论坛，重要的是，对基本的细胞和分子机制进行了批判性，这些机制可能解释了抗蛋白饮食的抗惊厥和神经保护作用。该研讨会将在整整三天的时间内举行，包括全体会议和迷你专题讨论会，以及专门针对特定医疗保健专业人员和研究人员组的海报和突破性会议。虽然研讨会的大部分重点将放在癫痫的饮食疗法上，但最后一天将回顾我们对其他神经系统疾病的饮食疗法的临床和实验经验患病的大脑。另一个实际的短期目标将是让与会者共享信息并建立临床和研究合作。它需要一个多学科的团队才能成功实施生酮饮食，适当研究并改善它。这种合作精神构成了这次国际研讨会的核心原理。公共卫生相关性：该研讨会的基本目标是分享有关癫痫饮食疗法快速扩展的主题的最新信息，并定义将来应提出的重要临床和研究问题。虽然有一些国际会议专门讨论了KD的主题，但没有一个人全面研究了这种悠久的治疗方法的临床和基础科学方面。因此，我们认为，该研讨会可能是第一次致力于这个长期以来的医学领域的具有里程碑意义的科学会议。