Building Non-Communicable Eye Disease Research Capacity in India

在印度建设非传染性眼病研究能力

• 批准号: 10676301
• 负责人: Joshua Robert Ehrlich
• 金额: $ 22.71万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676301
• 关键词: Address; Age; Aging; American; Blindness; Capsicum; Clinical Research; Clinical and Translational Science Awards; Collaborations; Dedications; Dementia; Disease; Education; Educational Status; Elderly; Environment; Epidemic; Eye; Eye diseases; Faculty; Funding; Grant; Home; Hospitalization; India; Institution; Intervention; Knowledge; Life Cycle Stages; Mental Depression; Mentors; Methods; Michigan; Needs Assessment; Population; Recording of previous events; Research; Research Personnel; Research Training; Risk Factors; Role; Sensory; Surveys; Training; Training Activity; Training Programs; United States National Institutes of Health; Universities; Vision; Visual; Visual impairment; aging population; blind; care systems; career; clinical epidemiology; design; disability; education research; epidemiology study; fall risk; middle age; mortality; population health; programs; skills; success; training opportunity; years lived with disability

ABSTRACT India is home to over 17% of the world’s population and to 25% of those who are blind or visually impaired worldwide. Blindness and vision impairment are the fourth leading cause of years lived with disability in India and are the number one cause in those age 70 and older, a segment of the Indian population that is rapidly growing. Over 90% of vision loss in India is due to non-communicable disease, the majority of which is avoidable. Poor vision is associated with wide-reaching consequences, including an increased risk of falls, dementia, depression, disability, loss of independence, longer and more frequent hospitalizations, and increased mortality. Despite the large and growing burden of non-communicable eye disease, particularly among older adults, the shortage of research expertise in India to characterize the epidemic and understand its causes and consequences is a critical barrier to intervening effectively and reducing its population health impact. Therefore, the focus of this training program is on building clinical-epidemiological research capacity, with an emphasis on lifecourse analyses applied to the study of non-communicable eye disease (NCED) in older adults. Given the aging of the Indian population and the disproportionate impact of NCED on older Indians, it is critical to train Indian vision researchers in the research principles and methods that will enable them to effectively address this critical need. Moreover, we currently lack knowledge from a lifecourse perspective to understand the effects of early- and mid-life exposures on late-life vision and vision-related disability in India. Research specific to the Indian context is vital to determine key risk factors and disability consequences of NCED, and to develop effective contextualized interventions. The proposed research capacity building program will draw upon the exceptional institutional environments at the Aravind Eye Care System (AECS) in India and at the University of Michigan (UM), including the NIH-funded UM Claude D. Pepper Older Americans Independence Center and Clinical and Translational Science Award. The UM and AECS have a long-standing history of collaboration and educational exchanges. Based on the results of a needs assessment survey, doctoral- and masters-level training tracks have been designed to meet the needs of early- and mid-career AECS faculty who aspire to careers in clinical-epidemiological research. The aims of this program include: 1) to provide comprehensive graduate-level training in the conduct of clinical and epidemiologic research for trainees from AECS who will be equipped to take a leading role in NCED and sensory aging research in India; 2) to develop the mentoring and research education skills of AECS faculty; and 3) to establish research training opportunities at AECS that are offered to a broad regional audience. All training activities will be transitioned to AECS by the end of the 5-year grant period. Both partner institutions are dedicated to the success of this training program and to its strong potential to address the growing epidemic of NCED and visual disability among India’s rapidly aging population.

抽象的 印度拥有世界上超过 17% 的人口以及 25% 的盲人或视力障碍者 在世界范围内，失明和视力障碍是印度致残的第四大原因。 这是印度 70 岁及以上人群中的首要原因，而这一群体在印度人口中正迅速增长。 印度 90% 以上的视力丧失是由非传染性疾病造成的，其中大部分是非传染性疾病。 视力不佳会带来广泛的后果，包括增加跌倒的风险， 痴呆、抑郁、残疾、丧失独立性、住院时间更长且更频繁，以及 尽管非传染性眼病的负担巨大且不断增加，尤其是死亡率增加。 在老年人中，印度缺乏研究专业知识来描述这种流行病的特征并了解其情况 原因和后果是有效干预和降低人口健康的关键障碍 因此，本次培训的重点是临床流行病学研究能力建设， 重点是应用于非传染性眼病（NCED）研究的生命历程分析 鉴于印度人口老龄化以及 NCED 对老年人的影响不成比例。 印度人，对印度视觉研究人员进行研究原理和方法方面的培训至关重要，这将使他们能够 此外，我们目前缺乏生命历程的知识。 了解早年和中年暴露对晚年视力和视力相关的影响的观点 印度的残疾状况。针对印度情况的研究对于确定关键风险因素和残疾至关重要。 NCED 的后果，并制定有效的情境干预措施。 能力建设计划将利用阿拉文眼科中心卓越的制度环境 印度和密歇根大学 (UM) 的系统 (AECS)，包括 NIH 资助的 UM Claude D. 佩珀美国老年人独立中心和临床与转化科学奖。 AECS 有着悠久的合作和教育交流历史。 需求评估调查，设计博士、硕士层次的培训课程以满足需求 早期和中期职业生涯的 AECS 教员，他们渴望从事临床流行病学研究。 该计划包括： 1) 提供临床和临床实践方面的全面研究生水平培训 为 AECS 的学员提供流行病学研究，他们将有能力在 NCED 和 印度的感官衰老研究；2) 发展 AECS 教师的指导和研究教育技能； 3) 在 AECS 为广大地区受众提供研究培训机会。 培训活动将在 5 年资助期结束时过渡到 AECS。 致力于该培训计划的成功及其解决日益增长的问题的强大潜力 NCED 和视力障碍在印度迅速老龄化的人口中流行。