Training Program in Neuroengineering and Medicine

神经工程和医学培训计划

• 批准号: 10659115
• 负责人: Brian Litt
• 金额: $ 48.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659115
• 关键词: Medicine; Training Programs

The aim of our multidisciplinary institutional training program, based in the Schools of Medicine and Engineering at the University of Pennsylvania, is to train predoctoral engineering students and physician postdoctoral fellows in Neuroengineering and its clinical translation. Disorders of the nervous system, such as stroke, epilepsy, Parkinson’s disease, depression, dementia, and head trauma, constitute 35% of all disease and disability, and the burden is rising. There is an explosion of promising therapies for these disorders in new technologies to image, analyze, and modulate neural circuits, but translating these therapies from the laboratory to patients is a challenge. It requires talented engineers educated in clinical science and technically proficient physicians who speak the same language. Together these investigators must navigate a complex scientific, regulatory, and clinical landscape. Despite the huge demand, few formal, interdisciplinary Neuroengineering training programs exist. Our program is shared by the Penn Schools of Medicine and Engineering focused on Neuroengineering and Clinical Translation and recruits from an excellent pool of ~60 MD fellows and 55-75 PhD students each year. Physician and Engineering trainees will together become fluent in cutting-edge technologies at the forefront of Neuroengineering, such as devices, neurostimulation, machine learning, algorithm development, cloud computing, nanotechnology and materials science. They will innovate new therapies for human disease and gain a thorough understanding of the clinical, regulatory, and developmental environments necessary to safely bring new technologies to patients. The program’s core is a group of collaborative, multidisciplinary faculty mentors in engineering and the clinical neurosciences. In addition to dedicated neuroengineering research, our training program includes: (1) a longitudinal mentored clinical experience for PhD candidates, (2) engineering lab immersion and tutorial for MD postdoctoral fellows, (3) courses and seminars in Engineering, Neuroscience, Medicine and Statistics, (4) training in the proper conduct of research, (5) workshops on professional and career development, including scientific writing, oral presentations, and laboratory management, (6) new to the program will be a dedicated statistician and expert guest speakers leading intensive didactic seminars on quantitative tools and approaches, experimental design, and statistical methodology, and (7) all journal clubs, workshops and one-on-one mentoring will have time devoted to promoting quantitative literacy and thinking to address issues in research. The program, unique at Penn, leverages a superb research and training environment, including a compact campus where robust centers for Engineering, Medicine, Neuroscience and Statistics all reside within two blocks of each other, united through Penn’s Center for Neuroengineering and Therapeutics.

我们位于宾夕法尼亚大学医学与工程学院的多学科机构培训计划的目的是培训神经工程及其临床转化领域的博士前工程学生和医师博士后研究员，例如中风、中风、神经系统疾病和神经系统疾病。癫痫、帕金森病、抑郁症、痴呆症和头部外伤占所有疾病和残疾的 35%，而且负担正在增加。针对这些疾病的有希望的治疗方法在神经成像、分析和调节方面出现了爆炸式增长。尽管这些研究人员必须共同应对复杂的科学、监管和临床环境，但将这些疗法从实验室转移到患者身上是一项挑战。需求巨大，但正式的跨学科神经工程培训项目很少。我们的项目由专注于神经工程和临床翻译的宾夕法尼亚大学医学与工程学院共享，每年从大约 60 名医学博士研究员和 55-75 名博士生中招募。医生和工程实习生将共同熟悉神经工程前沿的尖端技术，如设备、神经刺激、机器学习、算法开发、云计算、纳米技术和材料科学，他们将为人类疾病创新新疗法并获得成功。对安全地为患者带来新技术所必需的临床、监管和发展环境的透彻了解。除了专门的神经工程研究之外，该项目的核心是一群协作的、多学科的工程和临床神经科学导师。培训计划包括：(1) 为博士生提供纵向指导的临床经验，(2) 为医学博士后研究员提供工程实验室浸入式教学和辅导，(3) 工程、神经科学、医学和统计学方面的课程和研讨会，(4) 相关领域的培训正确进行研究，(5) 关于专业和职业发展的研讨会，包括科学写作、口头报告和实验室管理，(6) 该计划的新成员将是一名专门的统计学家和专家嘉宾演讲者，领导有关定量工具和知识的密集教学研讨会方法、实验设计和统计方法，以及（7）所有期刊俱乐部、研讨会和一对一指导将有时间致力于促进定量素养和思维，以解决研究中的问题。该项目是宾夕法尼亚大学独有的，利用一流的研究和培训环境，包括一个紧凑的校园，强大的工程、医学、神经科学和统计学中心都位于彼此相隔两个街区的范围内，通过宾夕法尼亚大学神经工程和治疗中心联合起来。

项目成果

Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids.

RGS-LOV 光感受器与阴离子膜磷脂的直接光调节结合。

• 发表时间: 2018-08-14
• 影响因子: 11.1
• 作者: Glantz, Spencer T;Berlew, Erin E;Jaber, Zaynab;Schuster, Benjamin S;Gardner, Kevin H;Chow, Brian Y
• 通讯作者: Chow, Brian Y

Electrocorticography reveals spatiotemporal neuronal activation patterns of verbal fluency in patients with epilepsy.

皮质电图揭示癫痫患者语言流畅性的时空神经元激活模式。

• 发表时间: 2020
• 影响因子: 2.6
• 作者: Williams Roberson, Shawniqua;Shah, Preya;Piai, Vitória;Gatens, Heather;Krieger, Abba M;Lucas 2nd, Timothy H;Litt, Brian
• 通讯作者: Litt, Brian

Alcohol for seizure induction in the epilepsy monitoring unit.

酒精用于癫痫监测装置中的癫痫发作诱导。

• 发表时间: 2024-01
• 作者: Emmert, Brian E;Xie, Kevin;Conrad, Erin C;Ghosn, Nina J;Bauman, Kristie;Korzun, Jacob;Kulick;Naveed, Omer;Hartmann, Nicole;LaRocque, Joshua J;Mindy Ganguly, Taneeta;Gugger, James J;Raghupathi, Ramya;Gelfand, Michael A;Davi
• 通讯作者: Davi

Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump.

使用集成磁性蠕动微泵的芯片上微流体渗滤。

• DOI: 10.1039/c7lc00954b
• 发表时间: 2017-11-07
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Liu JF;Yadavali S;Tsourkas A;Issadore D
• 通讯作者: Issadore D

Impaired transmissibility of atypical prions from genetic CJDG114V.

遗传性 CJDG114V 的非典型朊病毒的传播能力受损。

• 发表时间: 2018-08
• 作者: Cali, Ignazio;Mikhail, Fadi;Qin, Kefeng;Gregory, Crystal;Solanki, Ani;Martinez, Manuel Camacho;Zhao, Lili;Appleby, Brian;Gambetti, Pierluigi;Norstrom, Eric;Mastrianni, James A
• 通讯作者: Mastrianni, James A