Impacting the oral HPV continuum: prevention, screening, and early detection

影响口腔 HPV 连续体：预防、筛查和早期检测

• 批准号: 10658898
• 负责人: Gypsyamber D'Souza
• 金额: $ 104.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658898
• 关键词: Behavioral; Biological; Biological Markers; Blood; Cancer Detection; Development; Early Diagnosis; HPV oropharyngeal cancer; HPV-High Risk; Human Papillomavirus; Human papillomavirus 16; Incidence; Individual; Infection; Knowledge; Lesion; Methods; Oral; Oropharyngeal; Persons; Prevention; Risk Factors; Salivary; Screening for cancer; United States; high risk; malignant oropharynx neoplasm; oral HPV; oral HPV infection; prevent; progression risk; screening

Human papillomavirus (HPV) causes the majority of oropharyngeal cancers in the United States, but we do not yet have any effective screening methods to detect these cancers. This knowledge gap is in part due to difficulties identifying oropharyngeal precursor lesions. However, several promising salivary and blood biomarkers have recently emerged that may be good markers of persistent oral HPV16 infection, the presumed pre-cursor to HPV-related oropharyngeal cancer. Given the increasing incidence of HPV-related oropharyngeal cancer, I propose to study the oral HPV continuum to answer the following 4 questions: 1) who is at high- risk for HPV-OPC and would benefit from screening, 2) What are the biologic and behavioral factors promoting oral HPV persistence and how can we reduce their effects, 3) how to optimally screen for persistent oral HPV16 infection and HPV-OPC, and 4) How to follow and treat people who screen positive for these biomarkers to prevent the development of HPV-related oropharyngeal cancer.

在美国，大多数口咽癌是由人乳头瘤病毒 (HPV) 引起的 但我们还没有任何有效的筛查方法来检测这些癌症。这 知识差距的部分原因是难以识别口咽部先兆病变。 然而，最近出现了几种有前途的唾液和血液生物标志物，它们可能是 持续性口腔 HPV16 感染的良好标志物，被认为是 HPV 相关的前体 口咽癌。鉴于 HPV 相关口咽癌的发病率不断增加，我 建议研究口腔 HPV 连续体，以回答以下 4 个问题：1) 谁处于高- HPV-OPC 的风险，并会从筛查中受益，2) 生物学和行为学有何影响？ 促进口腔 HPV 持续存在的因素以及我们如何减少其影响，3) 如何最佳地 筛查持续性口腔 HPV16 感染和 HPV-OPC，以及 4) 如何跟踪和治疗患者 对这些生物标记物进行阳性筛查以预防 HPV 相关疾病的发展 口咽癌。

项目成果

Oncogenic Oral Human Papillomavirus Clearance Patterns over 10 Years.

10 年来致癌性口腔人乳头瘤病毒清除模式。

• 发表时间: 2024-04-03
• 作者: D'Souza, Gypsyamber;Tewari, Sakshi R;Troy, Tanya;Webster;Wiley, Dorothy J;Lahiri, Cecile Delille;Palella, Frank Joseph;Gillison, Maura L;Strickler, Howard D;Struijk, Linda;Waterboer, Tim;Ho, Ken;Kwait, Jennafer;Lazar, Jason
• 通讯作者: Lazar, Jason

Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study.

丰富的筛查人群中口腔和血液致癌性人乳头瘤病毒生物标志物的患病率：MOUTH 研究的基线结果。

• 发表时间: 2023-08-01
• 影响因子: 6.2
• 作者: D'Souza, Gypsyamber;Tewari, Sakshi R;Troy, Tanya;Waterboer, Tim;Struijk, Linda;Castillo, Rachel;Wright, Hannah;Shen, Michael;Miles, Brett;Johansson, Mattias;Robbins, Hilary A;Fakhry, Carole
• 通讯作者: Fakhry, Carole

Priorities of human papillomavirus-associated oropharyngeal cancer patients at diagnosis and after treatment.

人乳头瘤病毒相关口咽癌患者诊断时和治疗后的优先事项。

• 发表时间: 2019
• 影响因子: 4.8
• 作者: Windon, Melina J;Fakhry, Carole;Faraji, Farhoud;Troy, Tanya;Gourin, Christine G;Kiess, Ana P;Koch, Wayne;Eisele, David W;D'Souza, Gypsyamber
• 通讯作者: D'Souza, Gypsyamber

Association of Tumor Site With the Prognosis and Immunogenomic Landscape of Human Papillomavirus-Related Head and Neck and Cervical Cancers.

肿瘤部位与人乳头瘤病毒相关头颈癌和宫颈癌的预后和免疫基因组景观的关联。

• DOI: 10.1001/jamaoto.2021.3228
• 发表时间: 2021-11-18
• 期刊: JAMA otolaryngology-- head & neck surgery
• 作者: G. Zhu;N. Amin;Matthew E Herberg;C. Maroun;Hao Wang;M. Guller;C. Gourin;L. Rooper;Peter S. Vosler;M. Tan;G. D’Souza;W. Koch;D. Eisele;T. Seiwert;C. Fakhry;D. Pardoll;Rajarsi M;al;al
• 通讯作者: al

From presumed benign neck masses to delayed recognition of human papillomavirus-positive oropharyngeal cancer.

从假定的良性颈部肿块到延迟识别人乳头瘤病毒阳性口咽癌。

• 发表时间: 2020
• 作者: Davis, Ruth J;Rettig, Eleni;Aygun, Nafi;Rooper, Lisa;D'Souza, Gypsyamber;Eisele, David W;Fakhry, Carole
• 通讯作者: Fakhry, Carole