2022 CCS Oral Microbiome and Pulmonary Function Supplement

2022 CCS 口腔微生物组和肺功能补充剂

基本信息

批准号：
10659696
负责人：
Gypsyamber D'Souza
金额：
$ 1.54万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-09 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659696
关键词：
Acquired Immunodeficiency Syndrome Address Alcohol consumption Antibiotics Bacteria Biological Assay Blood specimen Cardiovascular Diseases Cell Separation Chronic Obstructive Pulmonary Disease Clinical Data Dental Dental Care Dental Hygiene Dental caries Diet Disease Environment Evaluation Funding Gingivitis HIV HIV Seronegativity Health Hypertension Immune response Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins Immunologic Deficiency Syndromes Immunologic Markers Individual Inflammation Inflammatory Response Pathway Influentials Intervention Investigation Knowledge Lead Link Lung Lung diseases Magnetism Measurement Measures Medicine Microbe North Carolina Oral Oral cavity Oral health Outcome Participant Pathogenesis Periodontitis Peripheral Persons Play Population Predisposition Property Pulmonary Emphysema Pulmonary Inflammation Pulmonary function tests Quality of life Questionnaires Research Personnel Respiratory Signs and Symptoms Risk Factors Role Saliva Sampling Science Site Smoking Stroke Systemic disease Taxonomy Techniques Testing Time Toothbrushing Training United States National Institutes of Health Universities Visit airway obstruction antiretroviral therapy bacterial community comorbidity cytokine data centers dysbiosis functional disability fungus improved insight interdisciplinary collaboration lung health microbial microbial community microbial host microbiome microbiome analysis microbiome composition modifiable risk mortality next generation novel oral HIV oral lesion oral microbiome pulmonary function response saliva sample social health determinants sociodemographic factors soft tissue systemic inflammatory response therapy development vaping

项目摘要

Abstract. FY 2022 OAR Strategic Funds are requested to perform a detailed investigation of the relationship of the oral microbiome, immune response, and HIV to chronic obstructive pulmonary disease (COPD). COPD, including airway obstruction and emphysema, is an increasing health problem in people with HIV (PWH) even in the current era of antiretroviral therapy (ART). Our preliminary data suggest that the oral microbiome is associated with lung function, but we lack a detailed understanding of the role of particular microbial communities and the potential mechanisms underpinning the association, which currently impedes development of intervention strategies. We will utilize oral data, microbiome analyses, blood specimens, and pulmonary function measures already being collected throughout MWCCS in visits 102 and 103 in order to analyze the relationship of oral health and the oral microbiome to lung function. We will also perform measurements of peripheral cytokines, inflammatory responses, and the oral cavity environment to assess potential mechanisms linking the microbiome to lung health. These investigations will be performed in all individuals who have completed pulmonary function testing across MWCCS. We will then perform detailed oral evaluations and collect microbial samples from multiple oral niches in a subset of participants to better delineate relationships of specific oral health components and lung function at Pitt and UNC. Using a novel technique to identify immunoglobulin-bound bacteria and fungi, we will identify key microbes that drive host response and are related to COPD. These investigations will identify potentially modifiable targets contributing to COPD in PWH. We will address NIH high priority AIDS-designated topics of: 1) a common and high-burden HIV- associated comorbidity; 2) interdisciplinary collaborations among experts in pulmonary disease, microbiome, dental medicine, and analytics; 3) disparities in HIV given impact of social determinants of health on both lung function and oral health; 4) fundamental discovery in cross- cutting science; and 5) training the next generation of HIV investigators.

抽象的。 2022 财年 OAR 战略基金需要对以下方面进行详细调查：口腔微生物组、免疫反应和 HIV 与慢性阻塞性肺疾病的关系肺部疾病（慢性阻塞性肺病）。 COPD，包括气道阻塞和肺气肿，是一种即使在当前抗逆转录病毒时代，艾滋病毒感染者 (PWH) 的健康问题也日益严重治疗（ART）。我们的初步数据表明口腔微生物组与肺相关功能，但我们对特定微生物群落的作用缺乏详细了解以及目前阻碍该协会发展的潜在机制制定干预策略。我们将利用口腔数据、微生物组分析、血液样本和肺功能测量值已在 MWCCS 中收集访问 102 和 103，以分析口腔健康和口腔微生物组与健康之间的关系肺功能。我们还将进行外周细胞因子、炎症因子的测量反应和口腔环境来评估联系的潜在机制微生物群对肺部健康的影响。这些调查将在所有患有以下疾病的个人中进行：完成 MWCCS 的肺功能测试。然后我们将进行详细的口语评估并从参与者子集中的多个口腔生态位收集微生物样本更好地描述皮特和肺功能的特定口腔健康成分和肺功能之间的关系北卡罗来纳大学。使用新技术来识别免疫球蛋白结合的细菌和真菌，我们将识别驱动宿主反应并与慢性阻塞性肺病相关的关键微生物。这些调查将确定导致感染者慢性阻塞性肺病（COPD）的潜在可修改目标。我们将讨论 NIH 指定的高优先级艾滋病主题：1) 一个常见且高负担的艾滋病毒- 相关合并症； 2）肺部疾病专家之间的跨学科合作，微生物组、牙科医学和分析； 3) 由于社会因素的影响，艾滋病毒的差异肺功能和口腔健康的健康决定因素； 4）交叉领域的基本发现切割科学； 5) 培训下一代艾滋病毒调查人员。