Neuroscience Training Program at Washington University

华盛顿大学神经科学培训项目

• 批准号: 10656326
• 负责人: Timothy Holy
• 金额: $ 53.53万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656326
• 关键词: Neurosciences; Training Programs; Universities; Washington

This proposal, from the Neuroscience Program in Washington University’s Division of Biology and Biomedical Sciences (DBBS), is a new application to the Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciences. The overarching goals of our Neuroscience program are to equip our trainees with a firm foundation in nervous system function and dysfunction, the ability to identify problems and design strategies to address them critically and rigorously, and the skills required to perform, present, and mentor others in research. The strengths of our current training program include a strong and evolving curriculum to address critical areas of modern neuroscience and the skills necessary for success in any neuroscience career, a focus on improving diversity of students in neuroscience and retaining diverse students in the program, a collegial and collaborative atmosphere, broad institutional support, multiple neuroscience-related opportunities for community outreach and teaching and a supportive administrative structure that facilitates all aspects of the educational process, from recruitment of students to thesis defense and beyond. This proposal builds on these features with ongoing and future initiatives aimed at improving quantitative, experimental and statistical thinking, facilitating interdisciplinary and/or advanced training in areas relevant to a student’s research, modernizing curriculum delivery, providing evidence-based ethics training to address well-publicized problems of rigor and reproducibility, and assessing the impact of these initiatives and modifying their implementation as needed. We are requesting 11 slots for students in their 1st and 2nd years. Students will emerge from this program with a stronger foundation in experimental and statistical thinking, ethics and methods to improve rigor and reproducibility. Faculty in the program will also benefit from exposure to emerging methods and approaches in these areas.

该提案来自华盛顿大学生物学和生物医学部的神经科学项目 科学 (DBBS) 是联合赞助的 Ruth L. Kirschstein 国家研究服务的一项新应用 奖励神经科学领域的机构博士前培训计划。 神经科学课程旨在为我们的学员提供神经系统功能和神经系统功能方面的坚实基础 功能障碍，识别问题并设计策略以批判性和严格地解决问题的能力，以及 在研究中执行、展示和指导他人所需的技能 我们当前培训的优势。 计划包括一个强大且不断发展的课程，以解决现代神经科学的关键领域和 任何神经科学职业成功所需的技能，注重提高学生的多样性 神经科学并保留多样化的学生参与该项目，学院和协作的氛围，广泛的 机构支持、多种与神经科学相关的社区外展和教学机会以及 支持性行政结构，促进教育过程的各个方面，从招募 该提案建立在这些持续和未来的特征之上。 旨在提高定量、实验和统计思维、促进跨学科的举措 和/或与学生研究相关领域的高级培训，使课程交付现代化，提供 基于证据的道德培训，以解决广为人知的严格性和可重复性问题， 评估这些举措的影响并根据我们的要求修改其实施。 为第一年和第二年的学生提供 11 个名额 学生将从该计划中脱颖而出，变得更加强大。 奠定实验和统计思维、伦理和方法的基础，以提高严谨性和可重复性。 该项目的教师也将受益于接触这些领域的新兴方法和途径。

项目成果

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.

脑脊液通过硬脑膜通道直接进入调节颅骨骨髓生态位。

• 发表时间: 2022-05
• 影响因子: 25
• 作者: Mazzitelli, Jose A;Smyth, Leon C D;Cross, Kevin A;Dykstra, Taitea;Sun, Jerry;Du, Siling;Mamuladze, Tornike;Smirnov, Igor;Rustenhoven, Justin;Kipnis, Jonathan
• 通讯作者: Kipnis, Jonathan

Loss of Gata1 decreased eosinophils, macrophages, and type 2 cytokines in regenerating nerve and delayed axon regeneration after a segmental nerve injury.

Gata1的缺失会减少神经再生过程中的嗜酸性粒细胞、巨噬细胞和2型细胞因子，并延迟节段性神经损伤后的轴突再生。

• 发表时间: 2023-04
• 影响因子: 5.3
• 作者: Liebendorfer, Adam;Finnan, Michael J;Schofield, Jonathon Blake;Pinni, Sai L;Acevedo;Schellhardt, Lauren;Snyder;Mackinnon, Susan E;Wood, Matthew D
• 通讯作者: Wood, Matthew D

A feasibility study transplanting macrophages to a segmental nerve injury.

将巨噬细胞移植到节段性神经损伤的可行性研究。

• 发表时间: 2023-11
• 影响因子: 3.4
• 作者: Pan, Deng;Schofield, Jonathon Blake;Schellhardt, Lauren;Snyder;Mackinnon, Susan E;Li, Xiaowei;Wood, Matthew D
• 通讯作者: Wood, Matthew D